Navigation Links
Excess Pounds Raise Risk of Breast Cancer Recurrence, Death: Study
Date:8/27/2012

By Kathleen Doheny
HealthDay Reporter

MONDAY, Aug. 27 (HealthDay News) -- Women who are overweight or obese when diagnosed with the most common form of breast cancer have a higher risk of recurrence than slimmer patients, according to a new analysis.

"Patients who are obese are significantly more likely to have a breast cancer recurrence despite optimal therapy," said study leader Dr. Joseph Sparano, associate chairman of oncology at Montefiore Medical Center, in New York City.

These overweight and obese women with hormone receptor-positive breast cancer -- which accounts for two-thirds of all cases worldwide -- are also at greater risk of dying compared to normal-weight women, he found.

The comparison found the obese women had "about a 30 percent increased risk of recurrence and 50 percent increased risk of death," Sparano said.

Hormone receptor-positive breast cancer requires estrogen to grow, and Sparano speculated that one possibility for the link might be increased production of estrogen in heavier women.

While the new study findings, published online Aug. 27 in the journal Cancer, echo some earlier research, there are important differences, Sparano said.

Other studies have been complicated by the fact that obese patients often have additional health problems, which may have prevented them from getting appropriate therapy, Sparano said.

In the new analysis, he looked at a relatively healthy patients, 6,885 women in all, enrolled in U.S. National Cancer Institute clinical trials with stage 1 to 3 breast cancer (cancers that had not spread to distant sites). They could not participate if they had serious health problems, such as liver, heart or lung disease.

The percentage considered obese (body mass index of 30 or higher) ranged from 25 to 37 percent in the three studies evaluated. Body mass index (BMI) is a calculation of fat content based on height and weight.

As BMI rose, the risk of recurrence or death increased incrementally. Being overweight but not obese also increased risk.

"Obesity is clearly associated with an increased risk, and even women who were not obese but overweight tend to have a high risk," Sparano said. However, he said he can't pinpoint a weight threshold at which the risk begins.

It's important to note that although a link between recurrence and excess weight was detected, the research does not show cause and effect.

Commenting on the study, Dr. Bette Caan, a senior research scientist at the Kaiser Permanente Division of Research in Oakland, Calif., said the researchers were able to address some of the shortcomings of previous studies.

"To me the big news is that it is showing obesity is only related to one subtype," Caan said. "It's the most common subtype.

"Breast cancer is not one disease but several diseases," she added.

What is not yet known, agreed Sparano and Caan, is whether reducing weight after cancer treatment might reduce the risk of recurrence or death.

Studies looking at the effect of reducing dietary fat on the risk of recurrence in obese women have come up with conflicting results. In one study, reduced fat didn't lead to weight loss or reduced recurrence.

More study is needed, these experts say. It might turn out that weight loss only plays a role in reducing recurrence risk for some women, Caan said.

More information

To learn about obesity and breast cancer, visit the U.S. National Cancer Institute.

SOURCES: Joseph Sparano, M.D., associate chairman, oncology, Montefiore Medical Center, and professor of medicine, Albert Einstein College of Medicine, New York City; Bette Caan, Dr.P.H., M.P.H., senior research scientist, Kaiser Permanente Division of Research, Oakland, Calif.; Aug. 27, 2012, online, Cancer


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. College Freshmen Urged to Keep Excess Pounds Away
2. Simple Measures May Curb Excessive Weight Gain in Pregnancy
3. Excessive sleepiness may be cause of learning, attention and school problems
4. Compounds activate key cancer enzyme to interfere with tumor formation
5. Extra Pounds May Offer Protection to Heart Failure Patients
6. Natural Sciences Repository Publishes Chromatography and Acidic Compounds Resources
7. Radiation for Childhood Cancer Might Raise Diabetes Risk
8. Missing Follow-Up Colonoscopies Could Raise Colon Cancer Risk
9. Older Dads May Raise Risk for Autism, Schizophrenia in Kids
10. Internists praise primary care practices inclusion in CPCI
11. Close Relatives Early Death May Raise Your Heart Risk: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Excess Pounds Raise Risk of Breast Cancer Recurrence, Death: Study
(Date:4/28/2016)... , ... April 28, 2016 , ... Head Over Heels ... 9 Western Championships. The competition will be held at the University of Montana on ... gymnasts west of the Mississippi River. , In order to qualify, Varize needed to ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... open availability of a new CDISC standard, Clinical Trial Registry (CTR) XML. ... This innovative standard will make it possible to build applications that generate ...
(Date:4/28/2016)... ... April 28, 2016 , ... Cosmetic Town, an online ... cosmetictown.com . The forum section was recently revamped and upgraded to allow even more ... in use across the country. , According to the senior editor of Cosmetic Town, ...
(Date:4/28/2016)... ... 2016 , ... Greener Hydroponics is now offering a large selection of Smart ... organic farmers and nurseries according to Sales Manager Joe Steele who says, “Now is ... is to offer wholesale level pricing and ultra-fast shipping for growers of any size.” ...
(Date:4/28/2016)... ... April 28, 2016 , ... In 2011, TIME magazine ... the emerging field of biomechatronics, technology that marries human physiology with electromechanics. He continues ... He is also the Founder of BionX , a leader in the field ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 27, 2016 ... in Zürich gab Strekin AG den Start ... zur Erhaltung des Resthörvermögens von Patienten, denen ... die umfassende Phase-II-Doppelblindstudie mit Placebo-Kontrollgruppe werden momentan ... wird während der Operation direkt ins Mittelohr ...
(Date:4/27/2016)... PARIS , April 27, 2016 ... Year-Over-Year Including 42% Growth in Recurring Consumable Sales  ... Mauna Kea Technologies (Euronext: MKEA, OTCQX: MKEAY) ... today announced its sales for the first quarter ended ... business and the execution of its commercial strategy. ...
(Date:4/27/2016)... 2016 Transparency Market Research has ... - Global Industry Analysis, Size, Share, Growth, Trends, and ... global skincare devices market was valued at US$ 7,255.8 ... a CAGR of 10.1% from 2015 to 2023 to ... the full Skincare Devices Market (Treatment Device - LED Therapy ...
Breaking Medicine Technology: