Navigation Links
Examination of lymph nodes provides more accurate breast cancer prognosis
Date:7/29/2013

After a breast cancer operation, the removed tumour is always examined, as its subtype can provide an indication of how aggressive the disease is. The patient's lymph nodes are not analysed in the same way. Yet the breast tumour can sometimes appear to be of a less aggressive type while the subtype in the lymph nodes gives a different and more worrying picture.

In these cases, it is the lymph nodes that provide the correct prognosis, according to new research at Lund University in Sweden. An analysis of the proliferation, hormone receptor status and HER2 status of the lymph nodes would in many cases show a significantly more accurate picture of the risk of metastases, i.e. a recurrence of the disease and its spreading to other organs.

"It would be easy to add such an analysis. It does not require any expensive specialist technology, but only an extension of the normal, routine pathology work", says Lisa Rydn, a consultant surgeon and researcher at Lund University.

The study covers 500 women in the early stages of breast cancer who underwent surgery in Lund or Helsingborg. Early-stage breast cancer is when the cancer has not yet spread to other organs. However, in approximately one third of all the women who underwent surgery for early-stage breast cancer, there were traces of the tumour in the lymph nodes, which can provide important additional information.

"Sometimes the molecular study showed the same subtype in the breast tissue and in the lymph nodes. But sometimes the types were different. And when we investigated the outcomes for the women 10 years later, the prognosis followed the subtype that was present in the lymph nodes and not the one in the breast", says Lisa Rydn.

Thus when doctors only examine the breast tissue, there is a risk that the tumour will be found to be of a low-risk type, which affects decisions on further treatment. The lymph nodes may meanwhile show signs of a more aggressive form of tumour, but that is never discovered.

"If, on the other hand, we start routinely analysing the lymph nodes as well, we can treat women in such cases with additional cytostatic and targeted drugs after their operation. This could prevent later recurrence of the disease" thinks Lisa Rydn.

A fairly small proportion of the patients in the study showed a difference in tumour type between the breast tissue and the lymph nodes. But since breast cancer is such a common disease, the number of patients affected nationally and globally will still be considerable and, for them, the difference can be that between life and death, the Lund researcher points out.


'/>"/>

Contact: Lisa Rydén
lisa.ryden@med.lu.se
46-706-720-923
Lund University
Source:Eurekalert

Related medicine news :

1. North American Seminars Receives NY State Approval for a New Physical Therapy Online Continuing Education Course, Examination and Treatment of the SI Joint
2. North American Seminars Introduces a New Online Continuing Education Course for Physical Therapists, Examination and Treatment of the Hip Joint
3. North American Seminars Introduces Vestibular Rehabilitation - Examination and Treatment, a New Physical Therapy Online Continuing Education Course
4. North American Seminars Introduces a New Online Continuing Education Course for Physical Therapists, Examination and Treatment of the SI Joint
5. Sharing examination questions threatens trust in medical profession
6. Report offers an in-depth examination of health centers role in family planning
7. Decision support system translates into high percentage of positive chest CT examinations
8. HIV-associated lymphoma survival has not improved during the antiretroviral therapy era
9. North Shore-LIJ Health System's Feinstein Institute to Receive $250,000 Grant from Lymphoma Research Foundation Grant to support research of Chronic Lymphocytic Leukemia
10. Innovative Technique Seeks to Prevent Lymphedema in Breast Cancer Patients
11. Radioimmunotherapy deemed safe and effective for lymphoma patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... people are unfamiliar with. The article goes on to state that individuals are now ... of these less common operations such as calf and cheek reduction. The Los Angeles ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas ... , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® ... Group (TGIG), has initiated cultivation and processing operations at its production facility, and ... Nevada. , Puradigm is the manufacturer of a complete system of proactive air ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
Breaking Medicine Technology: