Navigation Links
Evolution provides clue to blood clotting
Date:7/20/2011

Moving to an acidic environment, this amino acid, histidine, gains a positive charge. The group suspected that this charge may trigger the VWF building blocks to link together in a long chain.

But there are many histidines located throughout the chain. Like 26 letters of the alphabet form thousands of words, 20 essential amino acids form all proteins in the body. To identify which histidines might be guiding the amino acid chain to form the long VWF tubules, Sadler and his team looked to evolution.

"If a particular histidine is important in this process, it should be present in the same location across many species," Sadler says.

So Sadler's group, including the paper's first author, Luke T. Dang, who was an undergraduate student when he did this work, gathered the DNA sequences of VWF for humans, 19 other placental mammals, a marsupial, two birds, a reptile, an amphibian and five fish. Dang is now a graduate student at the University of Washington, Seattle.

"By lining up the sequences, we found a relatively small number of histidines that are in the same place across species," Sadler says. "It then becomes manageable to mutate them individually and see if that prevents von Willebrand Factor from assembling."

Out of the many histidines in the amino acid sequence of VWF, they found two that are important in sensing the pH change and guiding the building blocks to form chains in an acidic environment. When Dang replaced either of these histidines with an amino acid that provides no positive charge, the chain did not form. But when Dang forced a positive charge to always be present at these locations, the chain formed again.

"A positive charge at these positions is important for von Willebrand Factor to assemble properly so it can perform its biological function," says Sadler, also a hematologist who specializes in treating patients with blood clotting disorders. "Without VWF, you bleed."

According to Sadle
'/>"/>

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Genetic map of African-Americans to aid study of diseases, human evolution
2. UCSF-led team decodes evolution of skin and ovarian cancer cells
3. Scientists identify a novel mechanism for evolution of highly aggressive cancers
4. Evolutionary geneticist to give talk at UC Riverside on how biological species evolve and adapt
5. Single Gene Linked to Evolution of Human Brain
6. Center to revolutionize chemical manufacture is open for business
7. Polygamy hurt 19th century Mormon wives evolutionary fitness
8. Study looks into evolution of breast cancer in Spain
9. Punctuated evolution in cancer genomes
10. UH biochemist works to revolutionize ovarian cancer treatment
11. Biologists, educators recognize excellence in evolution education
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Evolution provides clue to blood clotting
(Date:7/9/2014)... innovative tool that captures heretofore hidden ways that cells ... protein that makes breast cancer cells more likely to ... cancer,s spread in part by blocking two other proteins ... suggests these two disease processes could have unexpected ties. ... 10 issue of Nature , points to the ...
(Date:7/9/2014)... in policing injection drug users in Russia might ... , A study, conducted by researchers from Boston ... collaboration with St. Petersburg Pavlov State University, sought ... the health outcomes of a cohort of HIV-positive ... Those who were arrested by police were more ...
(Date:7/9/2014)... NEW YORK (July 8, 2014) Researchers from ... College of Medicine of Yeshiva University will present ... being held July 12 July 17 in Copenhagen, ... triggers that could prompt transition from cognitive normality to ... of the Einstein Aging Study , established in ...
(Date:7/9/2014)... important organs in the human body. Its job is ... this is its synthesis function and that toxic ... its detoxification function. Lack of exercise and too much ... The resulting diseased cells can lead to inflammations, cancerous ... to the German Liver Foundation, over five million people ...
(Date:7/9/2014)... Qubec City, July 9, 2014 A study published ... Yves De Koninck and Robert Bonin, two researchers at ... pain hypersensitivity using a new method that involves rekindling ... discovery could lead to novel means to alleviate chronic ... at Universit Laval and Institut universitaire en sant mentale ...
Breaking Medicine News(10 mins):Health News:Protein pushes breast cancer cells to metastasize 2Health News:Protein pushes breast cancer cells to metastasize 3Health News:BU researchers relate arrests with HIV risk environment 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 3Health News:Telemedicine for patients with chronic liver diseases 2Health News:Telemedicine for patients with chronic liver diseases 3Health News:Discovery of a new means to erase pain 2
... respiratory woes , FRIDAY, Sept. 14 (HealthDay News) -- ... off the northwestern coast of Spain in November 2002 ended ... the first research to examine the long-term effects of this ... Prestige sank and spilled about 67,000 tons of ...
... Mozambique, Sept. 14 Aid provided by,The Prem Rawat ... 300 women and their families who were victims of ... After the flooding, caused by cyclones in this ... were displaced from their homes. The,Prem Rawat Foundation made ...
... Excellence in Environmental Toxicology (CEET) at the,University of ... over the next four years to study biological ... part of the National,Institutes of Health new Genes, ... unique collaboration between geneticists and,environmental health scientists. In ...
... following is a,statement by Mike Leavitt, Secretary of Health ... Rich McKeown, returns to Beijing as the,head of a ... my,Department, to begin formal negotiations on two binding Agreements ... of food and feed, and one on,the safety of ...
... Inventors say product dissolves naturally , THURSDAY, Sept. 13 (HealthDay ... every sidewalk: someone else,s used-up chewing gum. , But relief ... a non -stick, easy-to-remove version of chewing gum at ... Gum can be easily removed from shoes, clothes, hair and ...
... Bono and DATA Receive $100,000 for HIV & ... The National,Constitution Center, in partnership with the Greater ... 2007 Liberty Medal,ceremony live on http://www.libertymedal.org, ... the first time. The 2007 Liberty Medal will ...
Cached Medicine News:Health News:Oil Spill Cleanup May Hurt Workers' Lungs 2Health News:The Prem Rawat Foundation Supports Disaster-Relief Efforts in Mozambique 2Health News:Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure 2Health News:Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure 3Health News:Live Webcast With President George H.W. Bush as Bono and DATA Are Honored With National Constitution Center's 2007 Liberty Medal in Historic Philadelphia 2
(Date:1/15/2014)... Fla. , Jan. 15, 2014  In an unprecedented effort to ... TB in ambulances and other transport vehicles, an advanced and portable ... rescue personnel for the first time. In order ... with these deadly pathogens, West Palm Beach ...
(Date:1/15/2014)... Jan. 15, 2014 The Cadence Fitness & Health ... by the Medical Fitness Association, a non-profit organization assisting ... full potential. The Cadence Fitness & Health Center is ... and second in the Chicagoland area. "The ...
(Date:1/15/2014)... Quebec , Jan. 15, 2014  Valeant Pharmaceuticals International, ... announced that the applicable waiting period under the Hart-Scott-Rodino ... the previously announced tender offer by its indirect wholly-owned ... outstanding shares of common stock of Solta Medical, Inc. ...
Breaking Medicine Technology:Superbugs No Longer Ride In Rescue Vehicles 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
... NxStage ® Medical , Inc. (Nasdaq: NXTM ... announced the latest interim findings from its FREEDOM ... which found daily home hemodialysis treatments with the ... in various physical and mental quality of life measures. ...
... Senate passed S. 3187, its version of the Prescription ... to mitigate drug shortages, most notably mandating an early ... professional society concerned with the causes and treatment of ... in blood cancers such as leukemia, lymphoma, and myeloma, ...
Cached Medicine Technology:FREEDOM Study Data: Patients Experience Sustained Quality of Life Benefits with More Frequent Home Hemodialysis with the NxStage System One 2FREEDOM Study Data: Patients Experience Sustained Quality of Life Benefits with More Frequent Home Hemodialysis with the NxStage System One 3American Society of Hematology Statement on Senate Passage of Prescription Drug User Fee Act (PDUFA) 2
Indications For Usage: ,Single patient use on anesthetized patients and respiratory care patients who require a breathing circuit. The product is intended to be replaced at least once every 24 hours...
... Portex® Thermovent® T helps provide protection to the ... small and extremely lightweight making it ideal for ... a high rate of heat and moisture recovery, ... ,All HMEs and filters have ISO standard ...
... Portex® Thermovent® T helps provide protection to the ... small and extremely lightweight making it ideal for ... a high rate of heat and moisture recovery, ... ,All HMEs and filters have ISO standard ...
... provide protection to the exposed airway of the ... making it ideal for active young children as ... heat and moisture recovery, it ensures patient comfort ... filters have ISO standard tapered ends to assure ...
Medicine Products: