Navigation Links
Evolution of human genome's 'guardian' gives people unique protections from DNA damage
Date:1/16/2008

chromosomes that help shield against damage. Shorter telomeres can make people more susceptible to chromosomal damage and increase our risk of developing malignant tumors. When genes replicate, the process does not copy the very ends of the gene, so telomeres act like caps on the ends of shoelaces, helping preserve DNA structure and preventing genetic unraveling and loss of genetic information.

A clue to p53 functional differences may be found in sunlight. Exposure to the ultra-violet rays in sunlight activates the DNA-damage responses of the repair gene (Ddb2) in humans, but the same gene does not function in rodents. Some studies have suggested that rodents may have a reduced need for genetic protection from sunlight because they are nocturnal and have a fur shield.

Although the full implications of these evolutionary points remain far from clear, our work demonstrates that there has been both refinement and evolution of gene networks controlled by p53, Dr. Aronow said. Exciting work is underway by research groups within the National Cancer Institutes Mouse Models of Human Cancer Consortium to develop mice that are genetically engineered to test the combined effects of altering p53 and telomerase, the enzyme that controls the length and stability of repeating DNA sequences in the telomere region. Mouse models will continue to become progressively more powerful tools for studying human cancer and additional information about the p53 network will help us refine our interpretation of pre-clinical research that may lead to improved cancer prevention for at-risk and normal individuals.

In conducting their analysis of p53 target genes, the international research team used comparative DNA sequence analysis and functional tests of highly engineered yeast and mouse cell culture assays to examine 47 established p53 response elements in 14 vertebrate and non-vertebrate species. The study included researchers from the National Institute for Cance
'/>"/>

Contact: Nick Miller
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Local Oncology Group Leads Online Effort to Revolutionize Cancer Care
2. Join the Vitamin D Revolution: How to Get 30 Minutes of Daily Sunshine for Optimal Health
3. VIDEO from Medialink and Revolution Health: RevolutionHealth.com Launches Resolutions 2.0
4. UCLA Program Aims to Revolutionize Kidney Transplants
5. Prescription for an electronic revolution?
6. Adapting to pregnancy played key role in human evolution, study shows
7. Evolution Tips the Balance in Moms Favor
8. Informed Medical Communications Sells Consumer Internet Division to Revolution Health
9. Chinas Anti-Aging Revolution
10. New Low-Impact Cosmetic Surgery Treatments Revolutionizing Industry
11. ILC Dover Launches Revolutionary ArmorFlex (R) Pharmaceutical Product Contact Film
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... Como, Italy (PRWEB) March 31, 2015 ... that the design project Bruker EVOQ by Daniel Dion ... A' Design Award in Scientific Instruments, Medical Devices and ... Bruker EVOQ, Daniel Dion, the creative mind behind the ... Bruker EVOQ MS - developed under the direction of ...
(Date:3/31/2015)... 2015 Diane Blackburn-Zambetti is the ... Mesothelioma Applied Research Foundation (Meso Foundation). Blackburn-Zambetti will ... Health” at the BoRit Asbestos Superfund Citizen Advisory ... program will discuss anatomy, six types of asbestos, ... symptoms, treatments, prevention and proper communication with your ...
(Date:3/31/2015)... 2015 According to a recent YouGov/Huffington ... Americans interviewed supported detox and abstinence, while only 19% ... methadone.(1) Although many within the healthcare community advocate for ... suggest that most Americans concur with Novus Medical ... drug use is a better approach than prescribing other ...
(Date:3/31/2015)... (PRWEB) March 31, 2015 PharmMD ... Victor Mattingly to the newly created, senior executive role ... Mattingly’s mandate is the delivery of high quality, efficient, ... building on PharmMD’s current momentum as a market innovator ... Therapy Management. , “We were very strategic in ...
(Date:3/31/2015)... A team of Italian scientists is using nanoparticles ... mesothelioma cancer cells. Surviving Mesothelioma has just posted an ... Click here to read it now. , Curcumin, ... spice turmeric, has limited value as a cancer treatment ... di Napoli Federico II are getting around the problem ...
Breaking Medicine News(10 mins):Health News:Daniel Dion wins Golden in A' Medical Product Design Awards 2Health News:Mesothelioma Foundation to speak at BoRit Asbestos Superfund Citizen Advisory Group Meeting 2Health News:Novus Medical Detox Center Highlights Survey Findings: More Americans Support Detox and Rehab Over Methadone as Treatment for Heroin Addiction 2Health News:Novus Medical Detox Center Highlights Survey Findings: More Americans Support Detox and Rehab Over Methadone as Treatment for Heroin Addiction 3Health News:Novus Medical Detox Center Highlights Survey Findings: More Americans Support Detox and Rehab Over Methadone as Treatment for Heroin Addiction 4Health News:PharmMD Places Victor Mattingly in C-Suite, Company Focused on Medication Therapy Management and Part D Star Ratings 2Health News:New Research Reveals Novel Delivery Method for Potential Mesothelioma Treatment, According to Surviving Mesothelioma 2
... of Medicine (BUSM) have found that some medical inpatients ... intervention. The BUSM study appears in the May issue ... . , "Brief intervention shows promise for increasing receipt ... cognitive functioning or an alcohol- attributable diagnosis," said lead ...
... on human genome , , THURSDAY, April 23 (HealthDay News) -- ... has succeeded in sequencing the entire genome of the placid, ... biology of this bovine and related creatures (even humans), and ... two reports in the April 24 issue of Science ...
... Harvard Medical School today announced the launch ... cancer and other prostate conditions understand the issues related ... treatment. The website, www.HarvardProstateKnowledge.org , was ... medical oncology and urologic cancer. This website is especially ...
... Keeping Michigan Workers Working!LANSING, Mich., April 23 May ... MICHIGAN will hold a summit involving 120 of Michigan,s ... Workability in Michigan, www.workabilityim.org , ... professions and organizations who are passionate about promoting safer, ...
... MR procedure that uses diffusion-weighted imaging (DWI) to determine ... benign may help reduce unnecessary breast biopsies, according to ... in Bethesda, MD. DWI is a method that produces ... compartments (diffusion). , The study included 80 patients ...
... tubo ovarian abscesses help women avoid surgery, according to ... MA. Tubo ovarian abscesses (TOAs) are an infected collection ... They can occur in patients with complicated cases of ... study included 54 TOAs in 46 patients. Results showed ...
Cached Medicine News:Health News:Researchers find medical inpatients with unhealthy alcohol use may benefit from brief intervention 2Health News:Scientists From 25 Countries Sequence Cow Genome 2Health News:Scientists From 25 Countries Sequence Cow Genome 3Health News:Harvard Medical School Prostate Disease Website Guides Patients Through Decision-Making Process 2Health News:Workability in Michigan Summit to be Held May 1 2
(Date:3/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/sx7b45/european ... "European Laboratory Information System (LIS) Market by Product ... Laboratory Information System, Anatomic Pathology Laboratory Information System) ... offering. The European laboratory information systems ... of 7.6% from 2014 to 2019. ...
(Date:3/31/2015)... , March 31, 2015 ... today announced a strategic partnership with Medidata ... for clinical research in life sciences. Offering therapeutic ... CRO has deployed Medidata,s electronic data capture (EDC), ... Biorasi,s Phase I through IV global clinical trial ...
(Date:3/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/dlt2vp/north_american ... "North American Laboratory Information System (LIS) Market by ... Pathology Laboratory Information System, Anatomic Pathology Laboratory Information ... their offering. The North American Laboratory ... a CAGR of 7.8% from 2014 to 2019. ...
Breaking Medicine Technology:European Laboratory Information System Market Report 2015: Germany holds a larger share of the laboratory information systems market 2European Laboratory Information System Market Report 2015: Germany holds a larger share of the laboratory information systems market 3Biorasi Selects Medidata's Cloud-Based Platform for Optimal Trial Operations 2Biorasi Selects Medidata's Cloud-Based Platform for Optimal Trial Operations 3Biorasi Selects Medidata's Cloud-Based Platform for Optimal Trial Operations 4North American Laboratory Information System (Clinical Pathology Laboratory Information System, Anatomic Pathology Laboratory Information) Market 2015-2019 2North American Laboratory Information System (Clinical Pathology Laboratory Information System, Anatomic Pathology Laboratory Information) Market 2015-2019 3
... OXFORD, England, September 26, 2011 EJC App Now ... provider of scientific, technical and medical information products and services, today ... Journal of Cancer ( EJC ). Starting with the September ... will be available through the EJC App on the App Store. ...
... InterMune, Inc. (NASDAQ: ITMN ) today reported ... Society (ERS) Annual Congress supporting the longer-term safety and ... idiopathic pulmonary fibrosis (IPF), a devastating lung disease.  Approximately ... year, with an estimated median survival of only two ...
Cached Medicine Technology:Elsevier Launches European Journal of Cancer iPad Edition 2Elsevier Launches European Journal of Cancer iPad Edition 3New Data Demonstrate Longer-Term Safety Profile of Esbriet® 2New Data Demonstrate Longer-Term Safety Profile of Esbriet® 3New Data Demonstrate Longer-Term Safety Profile of Esbriet® 4New Data Demonstrate Longer-Term Safety Profile of Esbriet® 5New Data Demonstrate Longer-Term Safety Profile of Esbriet® 6
... Preserve your data for future generations. Most gels ... solid backing plate of our gel dryer, covering ... frame over them to hold the cellophane flat. ... frame with an open area somewhat larger than ...
... Most gels can be dried by positioning them ... dryer, covering them with wet semi-permeable cellophane and ... cellophane flat. Tut's Tombs also produce great fluorographs. ... larger than the gel to be dried. Note ...
... Preserve your data for future generations. Most gels ... solid backing plate of our gel dryer, covering ... frame over them to hold the cellophane flat. ... frame with an open area somewhat larger than ...
... Easy Breeze Air Gel Dryer : Dry up ... 24 gels 8 10 cm without a ... rapid drying, or no heat for controlled drying ... transparent, dried gels. Add and remove gels at ...
Medicine Products: