Navigation Links
Evolution of human genome's 'guardian' gives people unique protections from DNA damage
Date:1/16/2008

chromosomes that help shield against damage. Shorter telomeres can make people more susceptible to chromosomal damage and increase our risk of developing malignant tumors. When genes replicate, the process does not copy the very ends of the gene, so telomeres act like caps on the ends of shoelaces, helping preserve DNA structure and preventing genetic unraveling and loss of genetic information.

A clue to p53 functional differences may be found in sunlight. Exposure to the ultra-violet rays in sunlight activates the DNA-damage responses of the repair gene (Ddb2) in humans, but the same gene does not function in rodents. Some studies have suggested that rodents may have a reduced need for genetic protection from sunlight because they are nocturnal and have a fur shield.

Although the full implications of these evolutionary points remain far from clear, our work demonstrates that there has been both refinement and evolution of gene networks controlled by p53, Dr. Aronow said. Exciting work is underway by research groups within the National Cancer Institutes Mouse Models of Human Cancer Consortium to develop mice that are genetically engineered to test the combined effects of altering p53 and telomerase, the enzyme that controls the length and stability of repeating DNA sequences in the telomere region. Mouse models will continue to become progressively more powerful tools for studying human cancer and additional information about the p53 network will help us refine our interpretation of pre-clinical research that may lead to improved cancer prevention for at-risk and normal individuals.

In conducting their analysis of p53 target genes, the international research team used comparative DNA sequence analysis and functional tests of highly engineered yeast and mouse cell culture assays to examine 47 established p53 response elements in 14 vertebrate and non-vertebrate species. The study included researchers from the National Institute for Cance
'/>"/>

Contact: Nick Miller
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Local Oncology Group Leads Online Effort to Revolutionize Cancer Care
2. Join the Vitamin D Revolution: How to Get 30 Minutes of Daily Sunshine for Optimal Health
3. VIDEO from Medialink and Revolution Health: RevolutionHealth.com Launches Resolutions 2.0
4. UCLA Program Aims to Revolutionize Kidney Transplants
5. Prescription for an electronic revolution?
6. Adapting to pregnancy played key role in human evolution, study shows
7. Evolution Tips the Balance in Moms Favor
8. Informed Medical Communications Sells Consumer Internet Division to Revolution Health
9. Chinas Anti-Aging Revolution
10. New Low-Impact Cosmetic Surgery Treatments Revolutionizing Industry
11. ILC Dover Launches Revolutionary ArmorFlex (R) Pharmaceutical Product Contact Film
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... Alto, CA (PRWEB) September 15, 2014 ... anniversary since its founding in 2007. To mark the ... local community for supporting the village and helping it ... provides a safe, secure and fun community for seniors. ... to the community and live in their own homes. ...
(Date:9/15/2014)... Dennis Thompson ... News) -- The severe respiratory virus believed to have ... states has now spread to the Northeast, health officials ... confirmed on Friday more than a dozen cases of ... for children with asthma. And on Saturday, the ...
(Date:9/15/2014)... neuroscience research has shown that certain brain regions ... language, naming, and decision-making. , How and where ... to support complex cognition is still under investigation. ... Washington University in St. Louis, Missouri, believe that ... the brain to function as an integrated network. ...
(Date:9/15/2014)... 2014 According to a new market ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast, ... at USD 12,212.9 million in 2013 and is estimated ... CAGR of 7.2% from 2014 to 2020. , Spectrometry ... light within specific electromagnetic spectrum to identify variety of ...
(Date:9/15/2014)... San Diego, CA (PRWEB) September 15, 2014 ... globe will gather this week, September 17-20, at ... annual International Plant-based Nutrition Healthcare Conference . ... educate gatekeepers of dietary-related advice—our physicians and healthcare ... efficacy of whole food, plant-based nutrition and its ...
Breaking Medicine News(10 mins):Health News:Avenidas Village Celebrates Anniversary 2Health News:Kids' Severe Respiratory Virus Confirmed in Northeast 2Health News:Kids' Severe Respiratory Virus Confirmed in Northeast 3Health News:Network measures predict neuropsychological outcome after brain injury 2Health News:Spectrometry Market Expected to Reach USD 19.6 Billion Globally in 2020: Transparency Market Research 2Health News:Spectrometry Market Expected to Reach USD 19.6 Billion Globally in 2020: Transparency Market Research 3Health News:Spectrometry Market Expected to Reach USD 19.6 Billion Globally in 2020: Transparency Market Research 4Health News:Spectrometry Market Expected to Reach USD 19.6 Billion Globally in 2020: Transparency Market Research 5Health News:San Diego Plays Host This Week to International Plant-based Nutrition Healthcare Conference Featuring Drs. Ornish, Esselstyn, Campbell and Other Leading Experts 2Health News:San Diego Plays Host This Week to International Plant-based Nutrition Healthcare Conference Featuring Drs. Ornish, Esselstyn, Campbell and Other Leading Experts 3
... Center have discovered the genetic factors that make some mosquitoes ... protein in the mosquitos immune system is the key to ... with a parasite that causes malaria, a biochemical reaction is ... of grabbing on to the parasites surface and targeting it ...
... a teenager Scot of severe asthma. ,Fifteen-year-old ... had to give up sports and physical education lessons at ... had read somewhere about the benefits of playing wind instruments ... one. ,Being a proud Glasgow-born Scot, David ...
... 18 months ago said Friday she felt reborn, but admitted ... of sadness and wonder. ,"I am back in the ... expressions which allow them to communicate. And I am alive again," ... of Le Monde. ,But the single mother, whose nose, ...
... constant headlines in the western media, the emerging Asian ... has suspended the sale of a drug used to treat ... week alone, a former department head at the State Food ... and it was announced that production licenses of five drug ...
... Actress Katie Holmes has landed a place in OK! ... ,The former 'Dawson's Creek' actress topped the 'beauty ... her new sporty cropped haircut, leaving singers Beyonce and ... the magazine created a list of 19 celebrities in ...
... confessed that she had sex with former boyfriend Justin Timberlake despite ... married. ,"I've only slept with one person my whole ... Justin, and I thought he was the one. But I was ... most painful thing I have ever experienced was that break-up," Spears ...
Cached Medicine News:Health News:Genetic Factors Behind Mosquitoes Resistance to Malaria Identified 2Health News:World's First Face Transplant Patient Feels She is Alive Again 2Health News:China Cracks the Whip Against Drug Manufacturers Who Fail Quality Norms 2
(Date:9/15/2014)... 15, 2014 /PRNewswire/ -  Pivotal Therapeutics Inc. (OTCQX:PVTTF; ... company with a focus on Omega-3 therapies for ... the Board of Directors approved the granting of ... the close of business on Friday, September 12, ... common shares of the Company were granted in ...
(Date:9/15/2014)... 15, 2014 /PRNewswire-iReach/ -- "Spain Aesthetic Lasers and ... market data on the Spain Aesthetic Lasers and ... millions of US dollars, volume (in units) and ... Invasive Body Contouring Devices (Laser-Assisted Liposuction (LAL) Devices ... Devices, Ultrasound-Assisted Liposuction (UAL) Devices and Power Assisted ...
(Date:9/15/2014)... /PRNewswire-iReach/ -- On September 8, 2014, Dr. ... a Citizen Petition to Dr. Margaret Hamburg ... another Black Box Warning to Levaquin, Cipro, and ... a Black Box Warning for the following psychiatric ... or acts, loss of consciousness, delirium, depressed level ...
Breaking Medicine Technology:Pivotal Therapeutics Grants Incentive Stock Options 2Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 2Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 3Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 4Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 5Quinolone Vigilance Foundation Supports Citizen Petition Requesting Another Black Box Warning for Levaquin, Cipro, Avelox 2Quinolone Vigilance Foundation Supports Citizen Petition Requesting Another Black Box Warning for Levaquin, Cipro, Avelox 3
... Reportlinker.com announces that a new ... its catalogue: Epidemiology: ... risk factor for deep vein thrombosis ... http://www.reportlinker.com/p0536561/Epidemiology-Major-Abdominal-Surgery-–-A-key-risk-factor-for-deep-vein-thrombosis-and-pulmonary-embolism.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=NoCategory ...
... 2011 Zimmer Holdings, Inc. (NYSE and SIX: ZMH), ... will be participating in the Goldman Sachs 32nd Annual ... Palos Verdes, California, on June 7, 2011, at 8:40 ... of the presentation can be accessed via Zimmer,s Investor ...
Cached Medicine Technology:Reportlinker Adds Epidemiology: Major Abdominal Surgery - A key risk factor for deep vein thrombosis and pulmonary embolism 2Zimmer Holdings to Present at the Goldman Sachs 32nd Annual Global Healthcare Conference 2
Acuvue Toric is an exceptionally comfortable soft contact lens made especially for people with astigmatism. The Acuvue Toric lens is designed to comfortably fit the unique shape of your eye....
C 2.3K with lightweight headband: the practical alternative for spectacle-wearers. Delivered in protective designer case....
Easyloupes are exceptional optics that you have come to expect from Oculus. Available in either 1.8x or 2.5x magnification and 40 cm working distance (15.75 inches), they have the well-known durabili...
... designed for computer operators who require ... placed at different heights and distanced ... Card is printed two sided- black ... and uses two type sizes to ...
Medicine Products: