Navigation Links
Evolution of human genome's 'guardian' gives people unique protections from DNA damage
Date:1/16/2008

CINCINNATI Human evolution has created enhancements in key genes connected to the p53 regulatory network the so-called guardian of the genome by creating additional safeguards in human genes to boost the networks ability to guard against DNA damage that could cause cancer or a variety of genetic diseases, an international team of scientists led by Cincinnati Childrens Hospital Medical Center writes in the Jan. 22 Proceedings of the National Academy of Sciences. Because genetically engineered mouse models are increasingly powerful tools in understanding the risks and mechanisms of human diseases and rodents do not have the same evolution-based safeguards in p53 function as humans the study also underscores the need for additional considerations in the interpretation of research using rodent models.

Our findings are especially important because rodents are often used as model organisms to investigate the genetic origins of diseases that affect humans, such as cancer investigators evaluating the impact of DNA-damaging agents, said Anil Jegga, DVM, a researcher in the Division of Biomedical Informatics at Cincinnati Childrens. Rodent models remain important to our understanding of disease processes, although our study suggests the need to address experimentally the differences in p53 regulatory pathways between humans and rodent models.

In the study, Jegga and his colleagues used comparative functional genomics to look systematically at small DNA sequences associated with the promoters, or enhancers, of specific genes that carry out orders from p53. These promoter elements act like antennae responding to activated p53 by boosting target gene expression and function inside a cells nucleus. By comparing these response elements across nearly 50 different binding sites of genes in the p53 network, and looking specifically at genes that repair DNA damage in 14 species (from zebra fish to humans), researchers were able to reveal critical evoluti
'/>"/>

Contact: Nick Miller
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Local Oncology Group Leads Online Effort to Revolutionize Cancer Care
2. Join the Vitamin D Revolution: How to Get 30 Minutes of Daily Sunshine for Optimal Health
3. VIDEO from Medialink and Revolution Health: RevolutionHealth.com Launches Resolutions 2.0
4. UCLA Program Aims to Revolutionize Kidney Transplants
5. Prescription for an electronic revolution?
6. Adapting to pregnancy played key role in human evolution, study shows
7. Evolution Tips the Balance in Moms Favor
8. Informed Medical Communications Sells Consumer Internet Division to Revolution Health
9. Chinas Anti-Aging Revolution
10. New Low-Impact Cosmetic Surgery Treatments Revolutionizing Industry
11. ILC Dover Launches Revolutionary ArmorFlex (R) Pharmaceutical Product Contact Film
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Presently, disposable medical suppliers call for ... supplies segment. During the past two decades, the world ... an average 12.5% per year), primarily owing to the ... US is the largest market for disposable medical supplies ... The second position is held by Europe with a ...
(Date:7/11/2014)... York, NY (PRWEB) July 11, 2014 ... during the five years to 2014 on the heels ... of 2010 prompted farmers to dedicate a larger share ... ethanol production. More specifically, the regulations required the mixing ... rapidly expanding biofuel production in the United States created ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Ticket Down ... Tickets at the Sleep Train Amphitheatre in Wheatland, CA. ... that can compare to what the Sleep Train Amphitheatre can ... events and special attractions over the course of its existence ... the Sleep Train Amphitheatre in Wheatland (Sacramento metro area) will ...
(Date:7/11/2014)... July 11, 2014 Pigments are insoluble ... mainly three functions namely protective coating, opacity, and coloring. ... materials that impart color to substances such as paper, ... the pigments, which upon application impart color to the ... oxide, carbon black, and hematite. , The coloring action ...
(Date:7/11/2014)... 11, 2014 With the arrival of ... seeking cosmetic surgery and hair transplant procedures, up 80 ... expansive range of medical tourism destinations, the company is ... costs and achieve the look they have always ... the top name in the medical tourism industry, VisitandCare.com ...
Breaking Medicine News(10 mins):Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 2Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 3Health News:Corn Farming in Canada Industry Market Research Report Now Available From IBISWorld 2Health News:Corn Farming in Canada Industry Market Research Report Now Available From IBISWorld 3Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 2Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 3Health News:Americas Pigments Market Worth 1,099 Thousand MT by 2018 - New Report by MicroMarket Monitor 2Health News:Americas Pigments Market Worth 1,099 Thousand MT by 2018 - New Report by MicroMarket Monitor 3Health News:VisitandCare.com Reports Increase in Cosmetic and Hair Transplant Procedures for Men 2Health News:VisitandCare.com Reports Increase in Cosmetic and Hair Transplant Procedures for Men 3
... actually face tough times in life, are better equipped to ... revealed exactly// the contrary. A finding from the University of ... are vulnerable to deception rather than those who have grown ... School of Psychology found that rather than 'toughening up' individuals, ...
... researchers at the Washington University and the Group Health Centre ... regular exercise keeps Alzheimer’s at bay. It was initially thought ... now it is been disproved by the researchers. The researchers ... and a weak handshake are early signs of dementia. They ...
... highlighted the beneficial effects of consuming flavanol-rich cocoa on ... Journal of Nutrition//. ,Researchers found that certain ... of women's skin – increasing hydration, decreasing skin roughness ... against UV damage. The German scientists attributed the observed ...
... very same day Prince Charles urges the World Health ... and complementary medicines alongside scientifically// proven treatments, some of ... medicine into the NHS. ,Thirteen senior doctors ... British medicine have written to every hospital and primary ...
... Progress as we know it, has an expensive price tag ... hundred years has brought,tremendous wealth and opportunity to its people;// ... there are 30% Americans who are,over-weight or grossly obese. More ... land the country in a similar situation.,India has seen a ...
... beverages by the FDA (Food and Drug Administration), US indicated ... carcinogen in much higher amount than the recommended 5 parts ... these companies, and they had either decided to reformulate the ... had expressed concern regarding this, it was not an issue, ...
Cached Medicine News:Health News:Take it if you can - Tough Times in Life Churn out Greenhorns 2Health News:Take it if you can - Tough Times in Life Churn out Greenhorns 3Health News:Cocoa good for skin? 2Health News:Eminent Doctors In UK Wants The NHS To Abandon Alternative Medicines: 2Health News:The Price Paid for New Lifestyle 2Health News:Soda Drinks Contain Benzene - A Carcinogen, Reports FDA 2Health News:Soda Drinks Contain Benzene - A Carcinogen, Reports FDA 3
(Date:7/10/2014)... 2014  BC Technical, the largest nationwide, non-OEM provider ... Inc., a leading provider of Siemens Nuclear Medicine and ... naming BC Technical as the authorized provider of service ... and BC Technical announced today that the two companies ... as the service and systems provider for MiE,s camera ...
(Date:7/10/2014)... , July 10, 2014 CVS Caremark Corporation ... of directors has approved a quarterly dividend of $0.275 (27.5 ... is payable on August 1, 2014, to holders of record ... CVS Caremark is dedicated to helping people on ... company in the United States . Through ...
(Date:1/15/2014)... DUBLIN , Jan. 15, 2014  Research and Markets ... "Dental Consumables Market - Global Industry Analysis, Size, ... report to their offering. (Logo: ... products which are used on patients in order to ...
Breaking Medicine Technology:BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3
... MASON, Ohio, May 30, 2012   AssureRx Health, ... $12.5 million Series C financing. The personalized medicine ... select the right drug for individual neuropsychiatric patients, ... for its two flagship pharmacogenomic products, GeneSightRx® Psychotropic ...
... May 30, 2012 The House is scheduled to vote on ... bill is weaker than similar legislation passed by the Senate ... patients from unsafe medical devices, according to Consumers Union, the ... "The FDA is hamstrung by a weak medical device law ...
Cached Medicine Technology:AssureRx Health Raises $12.5 Million Series C Financing 2AssureRx Health Raises $12.5 Million Series C Financing 3AssureRx Health Raises $12.5 Million Series C Financing 4House Voting Today on FDA Reform Act 2
Super High Density 360 degree radial rectal transducer. High resolution in the near field and lower frequencies for deeper penetration make this transducer the optimal choice when scanning the anal c...
Multi-frequency, HST, linear transducer with a longer (60mm) footprint. Available with puncture adapter and water path. This transducer incorporates ALOKAs exclusive Hemispheric Sound Technology and ...
... Linear high frequency ... breast and superficial ... exclusive Hemispheric Sound ... technologies. This multi-frequency ...
This versatile convex array abdominal transducer is multi-frequency, offering 5 levels of fundamental frequencies in addition to 4 settings of Harmonic frequencies. This transducer provides superb im...
Medicine Products: