Navigation Links
Evolution in the antibody factory
Date:3/11/2013

several keys that do not yet fit properly. This changes in the course of a process that immunologists refer to as "somatic hypermutation": B cells mutate those gene segments that determine the design of both the surface molecule and the soluble variation thus influencing how strongly the antibodies attach themselves to the pathogens. Those cells, in which the optimal fit of the key increases, survive and multiply. They then produce the desired molecule in large quantities and thus help us to get healthy again.

But how do the immune cells know that they are on the right way with this arbitrary mutation process, i.e. that the key will fit better later on? Scientists from England, Germany and Switzerland have now been able to answer this question jointly in a collaborative project between Dr. Kai-Michael Toellner, University of Birmingham, and Prof. Michael Meyer-Hermann, Head of the Department Systems Immunology. They published their findings in the renowned Journal of Experimental Medicine. Meyer-Hermann makes use of mathematical models to understand diseases more thoroughly and quicker. "Systems immunology enables us to simulate, in a short amount of time, numerous experimental conditions," he describes his area of expertise. With the aid of such mathematical simulations followed by experimental examinations, the researchers discovered that the antibody producers advance their own evolution, which represents without a doubt an alignment with the enormous selection pressure that we are subject to due to a constant threat from pathogens.

The stage for this process is the so-called germinal centres within the lymph nodes. Here, the maturing B cells encounter the antigens. The researchers' results suggest that completed antibodies from all germinal centres re-appear at the sites of antibody production and bind there to pathogen fragments as well. They represent competition thereby for those cells that are still in the process of refining the
'/>"/>

Contact: Birgit Manno
Birgit.Manno@helmholtz-hzi.de
49-531-618-11411
Helmholtz Centre for Infection Research
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. New Clues to the Evolution of the Human Brain
2. Evolution May Explain Runners High, Study Says
3. Losing money, emotions and evolution
4. A Revolutionary Dietary Paradigm: New Cookbook Features A SOS-free (Salt, Oil, Sugar ) Diet That Delivers the Optimal Food Plan for Renewing Health
5. Vygone Presents a Revolutionary Electro Waveform Device to Help Treat Molluscum Contagiosum Lesions
6. Oxford University Press launches Evolution, Medicine, and Public Health
7. Evolutionary information improves discovery of mutations associated with diseases
8. New Queens spin-in company to revolutionize cancer detection
9. An open platform revolutionizes biomedical-image processing
10. Genes of Africas Khoe-San Peoples Give Clues to Human Evolution
11. Bird tree tells new tale of evolution
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Evolution in the antibody factory
(Date:8/20/2014)... HealthDay Reporter WEDNESDAY, Aug. 20, 2014 ... group of rhesus monkeys from deadly Marburg virus, a very ... percent of those it infects, researchers report. The drug ... even when it was given three days after infection, according ... Science Translational Medicine . This is the first drug ...
(Date:8/20/2014)... the immune system is defective in people suffering from irritable ... ongoing issues with pain. , The research the first ... to explain why some painkillers may not offer satisfactory relief ... 10% of the community. There are different forms of ... often has the greatest impact on sufferers, quality of life. ...
(Date:8/20/2014)... Hundreds of Mirena IUD lawsuits ( http://www.themirenalawsuitcenter.com/ ... allegedly injured due to spontaneous migration of the IUD ... Superior Court, Bernstein Liebhard LLP reports. According to a ... Court has established procedures regarding the production of sales ... of the proceeding’s initial disposition pool. (In Re: Mirena ...
(Date:8/20/2014)... -- Loss of brain cells that act as a ... trouble falling and staying asleep, a new study suggests. ... severe and often results in nighttime confusion and wandering, ... from the Rush Memory and Aging Project, which includes ... are being followed until death, at which point their ...
(Date:8/20/2014)... HealthDay Reporter WEDNESDAY, Aug. 20, ... long been an option, but a new study shows that ... most common reasons women didn,t undergo reconstruction was that they ... or they were focused on their cancer treatment," said lead ... Sloan Kettering Cancer Center, in New York City. Also ...
Breaking Medicine News(10 mins):Health News:Drug for Ebola-Like Virus Shows Promise in Monkeys 2Health News:Drug for Ebola-Like Virus Shows Promise in Monkeys 3Health News:Pain treatments less effective for those with irritable bowel 2Health News:Mirena Lawsuit News: Case Management Order Issued in New Jersey Mirena Litigation, Bernstein Liebhard LLP Reports 2Health News:Mirena Lawsuit News: Case Management Order Issued in New Jersey Mirena Litigation, Bernstein Liebhard LLP Reports 3Health News:Mirena Lawsuit News: Case Management Order Issued in New Jersey Mirena Litigation, Bernstein Liebhard LLP Reports 4Health News:Seniors' Sleep Woes May Be Linked to Loss of Brain Cells 2Health News:Many Women Who Have Mastectomy Don't Get Breast Reconstruction: Study 2Health News:Many Women Who Have Mastectomy Don't Get Breast Reconstruction: Study 3
... for consolidating memories, researchers find , THURSDAY, Nov. 19 ... enhance associated memories upon waking, new research finds. , ... spatial memory, researchers at Northwestern University in Chicago showed ... played corresponding sounds, like a cat meowing and a ...
... A pediatric immunologist at The Children,s Hospital of ... the American Philosophical Society, an organization founded in ... Ph.D., received the Society,s Judson Daland Prize on ... treatment of inherited immune deficiency diseases. The ...
... ... Detective v3.0, with new enterprise-ready features and scalability , ... (PRWEB) November 19, 2009 -- Key Metric Software ... management software., , ,Duplicate File Detective v3.0 provides a number of new features ...
... Nov. 19 The gift of wings is the gift of ... US Airways is raising the bar for giving miles of hope. ... Mercy Medical Airlift and awarded hundreds of thousands of dollars in ... needing to travel for distant, specialized treatment. But through its Dividend ...
... (Tech) Vin Virtanen has developed a method for analysing ... connection and a wireless microphone. The objective was to ... to monitor snoring. By utilizing this technology, researchers from ... have investigated sleep disorders and further refined related screening ...
... , ... Services, known as one of the largest independent sales organizations for diagnostic imaging equipment, ... Nationwide Imaging Services a total turnkey solution for the medical imaging equipment industry. ... Brick, NJ (PRWEB) ...
Cached Medicine News:Health News:Sounds May Help Solidify Memories While Asleep 2Health News:Immunology expert at Children's Hospital receives APS prize for patient-oriented research 2Health News:Duplicate File Detective v3.0 Provides Enterprise-Grade Duplicate File Management 2Health News:US Airways to Match Miles with Mercy Medical Airlift 2Health News:A mobile phone or an MP3 player tells if you're sleeping soundly 2Health News:A mobile phone or an MP3 player tells if you're sleeping soundly 3Health News:Nationwide Imaging Services, Inc., Leader In Diagnostic Imaging Equipment, Announces The Creation Of New Business Division Nationwide Medical Equipment Services 2Health News:Nationwide Imaging Services, Inc., Leader In Diagnostic Imaging Equipment, Announces The Creation Of New Business Division Nationwide Medical Equipment Services 3
(Date:8/20/2014)... Calif. , Aug. 20, 2014 ... will be using advanced, ventilator technology from Covidien ... to care for patients. The ... more naturally, compared to conventional mechanical ventilation, and ... soon as possible. Patients on mechanical ventilation are ...
(Date:8/20/2014)... Aug. 20, 2014 Children aren,t the ... vaccinations to help prevent disease. The Centers for ... all adults, but currently, many adults are not ... National Immunization Awareness Month, and the American Lung ... especially those with lung disease, to talk with ...
(Date:8/20/2014)... -- Research and Markets  has announced the addition of ... their offering. Global Market Report of Pralmorelin ... and regionally ( Europe , Asia ... Latin America etc.). It captures Pralmorelin market trends, ... on three primary areas; manufacture methods & technology development, market ...
Breaking Medicine Technology:Torrance Memorial Medical Center Acquires Advanced Ventilator Technology to Enhance Patient Care 2American Lung Association Urges Adults with Lung Disease to Consult their Health Care Provider to Stay Current on Vaccinations 2American Lung Association Urges Adults with Lung Disease to Consult their Health Care Provider to Stay Current on Vaccinations 3Global Market Report of Pralmorelin 2
Compact format, fiber optic illumination for uniform reflection-free light. Polycarbonate housing with chrome-plated cone....
Sleek, all-metal head with large-diameter viewing window. 3X magnification....
Provides bright output and rotating lens with ultra-seal for pneumatic otoscopy....
... comes to laser treatment of AMD ... nothing compares to the Opal Photoactivator ... Visudyne (verteporfin for injection) therapy, the ... on any other laserfeatures,that ensure the ...
Medicine Products: