Navigation Links
Evidence lacking for widespread use of costly antipsychotic drugs, says Stanford researcher
Date:1/7/2011

tions. According to a 2004 study, a quarter of all residents of U.S. nursing homes had taken them. Among the drugs are quetiapine, aripoprazole (brand name, Abilify), olanzapine (Zyprexa) and risperidone (Risperdal), each with annual U.S. sales exceeding $1 billion.

Stafford's new study adds to concerns about the drugs, which have been the focus of thousands of lawsuits, and as a class make up the single largest target of litigation filed under the federal False Claims Act. All major companies selling new-generation antipsychotics have either recently settled cases for hundreds of millions of dollars or are currently under investigation for skewing results or using questionable marketing tactics.

In 2005, the FDA issued its strongest type of caution, the "black box" warning, for use of new-generation antipsychotics, because of increased risk of death for dementia patients.

"Most people think, 'If my doctor prescribed this, the FDA must have evaluated whether this drug was safe and effective for this use.' That's not true," said Stafford. When doctors prescribe drugs for purposes other than those approved by the FDA, it's called "off-label" use. Though it's riskier for patients, there's nothing illegal about it, and can make sense medically in some instances, Stafford said, especially if there are no approved treatments or if a patient has not responded to approved drugs.

Previous studies had shown that antipsychotic drug use is ballooning. Stafford's new study not only corroborated and updated these findings but also identified the fraction of off-label use that is based on uncertain evidence.

The researchers' first step was to analyze the results of a physicians' survey conducted by health-care information company IMS Health. The IMS Health National Disease and Therapeutic Index survey gives a snapshot of the conditions doctors treated and drugs they prescribed. About 1,800 physicians participate each calendar quarter an
'/>"/>

Contact: Rosanne Spector
manishma@stanford.edu
650-725-5374
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. More Evidence Links Avastin to Heart Failure in Breast Cancer Patients
2. Clinical practitioners not adhering to evidence-based guidelines for osteoarthritis
3. Study finds evidence of increased lung cancer risk among tuberculosis patients
4. Study Adds to Evidence That Rituximab Slows Lymphoma Symptoms
5. Evidence suggests e-cigs safer than cigarettes, researcher claims
6. More Evidence That Compression-Only CPR Works Best
7. New guideline finds no evidence for a popular back procedure
8. More Evidence That Glucosamine, Chondroitin Wont Help Ailing Joints
9. More Evidence That Vaccines Dont Cause Autism
10. New research finds evidence of charitable behavior in bacteria
11. More Evidence Virus Plays Role in Chronic Fatigue Syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... “Many people become overwhelmed by the thought of ... phone calls with insurance companies,” The Jones Firm explains ... free eBook on pedestrian and bicycle accidents . ... auto accident claims assures the injured individual that a ... their case while they focus on recovering. , ...
(Date:12/26/2014)... December 26, 2014 Parker & ... the best in heating, cooling and plumbing contractor ... hour emergency services in 2014 with regard to ... that Arizona is known for its incredibly hot ... understands the intricacies and details of a wide ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 The ... Analysis to 2023” focuses on the current treatment ... in the colorectal cancer market. Stivarga is a ... colon or rectal cancer. Boehringer Ingelheim is developing ... the treatment of refractory CRC in the US, ...
(Date:12/25/2014)... 2014 Recently, iFitDress.com, the popular online supplier ... announced its new selection of black one-shoulder cocktail dresses ... now; they are available at discounted prices, up to 70% ... will last for three weeks only. You know, we have ... are interested in our new items can visit our website ...
(Date:12/25/2014)... BambooFlooringChina.com sells many bamboo products and the business is ... company announces big discounts on its bamboo mats , ... is the world’s leader in bamboo flooring. According to ... 20, 2015. , The bamboo mats are made from ... All the bamboo strips for the mats are boiled ...
Breaking Medicine News(10 mins):Health News:Guide to Handling Pedestrian and Bicycle Accidents Released By The Jones Firm, Featured in Recent Article 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 4Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... Randy Dotinga HealthDay Reporter , TUESDAY, Dec. 6 (HealthDay ... nice house to a handy jet at your disposal, but the ... take years off your life? Maybe not, new research suggests. ... seem to lose years off their lives due to the effects ...
... at the meeting, which is being held in Budapest, ... using echocardiography to document early warning signs of adverse ... echocardiography to evaluate the protective role of ACE inhibitors ... "These studies open the way for the early identification ...
... HealthDay Reporter , TUESDAY, Dec. 6 (HealthDay News) -- ... tired; it may also increase your risk of developing type 2 ... of women found that those who worked rotating night shifts were ... hours, and the longer that they worked a rotating shift schedule, ...
... are too poor to afford pacemakers. But a study has ... and implanting them in Indian patients "is very safe and ... is a co-author of the study, published online ahead of ... helped conduct the research before coming to Loyola while he ...
... Supercomputer simulations at the Department of Energy,s Oak Ridge ... key class of proteins involved in drug detoxification. ... affiliated with ORNL and the University of Tennessee, have ... in a class of enzymes called P450s. Certain types ...
... HealthDay Reporter , TUESDAY, Dec. 6 (HealthDay News) ... hormone therapy do not appear to be at increased risk ... review of evidence. Hormone therapy called "androgen deprivation ... studies found that the therapy might increase the risk of ...
Cached Medicine News:Health News:Most U.S. Presidents Live Longer Than Their Peers 2Health News:EUROECHO 2011: Importance of echocardiography to evaluate cardio toxicity in cancer patients 2Health News:EUROECHO 2011: Importance of echocardiography to evaluate cardio toxicity in cancer patients 3Health News:EUROECHO 2011: Importance of echocardiography to evaluate cardio toxicity in cancer patients 4Health News:Rotating Shift Work May Boost Women's Diabetes Risk 2Health News:Rotating Shift Work May Boost Women's Diabetes Risk 3Health News:Reusing pacemakers from deceased patients is safe and effective, study finds 2Health News:Supercomputer reveals new details behind drug-processing protein model 2Health News:Hormone Drugs Might Not Raise Heart-Related Deaths in Prostate Patients 2Health News:Hormone Drugs Might Not Raise Heart-Related Deaths in Prostate Patients 3
(Date:12/24/2014)... and RALEIGH, N.C. , Dec. 23, ... International plc (NASDAQ: ENDP ) (TSX: ENL), ... ) announced today that they have submitted a New ... the U.S. Food and Drug Administration (FDA).  Buprenorphine HCl ... pain severe enough to require daily, around-the-clock, long-term opioid ...
(Date:12/22/2014)... JUNCTION, N.J. , Dec. 22, 2014 /PRNewswire/ ... company marketing its CytoSorb® blood purification technology to ... surgery patients in 28 countries worldwide, today announced ... Russo , MD, FACS, as its Senior Vice ... Dr. Di Russo ...
(Date:12/22/2014)... Calif. , Dec. 22, 2014 Apnea ... expanded corporate offices in Aliso Viejo ... that due to the tremendous growth and worldwide expansion, ... Sales of patented SnoreRx, the anti snore cure have ... He said, "We are now in 23 countries ...
Breaking Medicine Technology:Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5
... , OMAHA, Neb., Dec. 4 Amber ... Accreditation Commission for Health Care, Inc. (ACHC) for specialized ... provided comprehensive pharmacy care programs and services to meet ... one of the leading providers of services to transplant ...
... , ANNAPOLIS, Md., Dec. 4 PharmAthene, Inc. (NYSE ... against biological and chemical threats, announced today the presentation of ... its lyophilized recombinant Protective Antigen (rPA) based anthrax vaccine is ... up to and including 55 degrees C. The data ...
Cached Medicine Technology:Amber Pharmacy Earns Accreditation From ACHC 2PharmAthene Presents rPA Anthrax Vaccine Data at the 2009 HHS PHEMCE Stakeholders Workshop 2PharmAthene Presents rPA Anthrax Vaccine Data at the 2009 HHS PHEMCE Stakeholders Workshop 3PharmAthene Presents rPA Anthrax Vaccine Data at the 2009 HHS PHEMCE Stakeholders Workshop 4PharmAthene Presents rPA Anthrax Vaccine Data at the 2009 HHS PHEMCE Stakeholders Workshop 5
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: