Navigation Links
Every patient is unique: Individualized therapies for non-Hodgkin's lymphoma
Date:6/16/2008

NEW ORLEANS, La.Positron emission tomography (PET) could be an important tool for identifying non-Hodgkin's lymphoma patients who are likely to respond well to treatment with 90 ibritumomab tiuxetan (IT)the first radioimmunotherapy treatment approved for use by the U.S. Food and Drug Administration, said researchers at SNM's 55th Annual Meeting. PET imaging allows practitioners to identify patients who could be treated, predict how they would respond and identify relapses early in patients who have follicular lymphoma, a common type of slow-growing lymphoma.

"This study illustrates how PET could be used to advance the goal of personalized medicineidentifying and targeting the right treatment for each individual," said Stefano Fanti, professor of nuclear medicine at the Policlinico S. OrsolaUniversit di Bologna in Bologna, Italy, and a researcher of this study. "The functional data provided by PET are essential for determining stages of cancer, detecting disease relapses and evaluating how patients respond to particular therapies. Our study clearly indicates that the next stepusing PET for predicting how patients will respond to treatmentcan be achieved."

In the United States, about 65,000 new cases of non-Hodgkin's lymphoma are diagnosed every year. The number of new cases is on the rise, especially among older people and people whose immune systems are not functioning normally. Those at risk include people who have had organ transplants and those with human immunodeficiency virus (HIV).

Non-Hodgkin's lymphomas are a diverse group of cancers that develop in B or T lymphocytes, which are white blood cells that normally defend the body against bacteria and other pathogens. This group of cancers is actually the cause of more than 20 diseases, which have distinct appearances under the microscope and different clinical courses. Most non-Hodgkin's lymphomas are from B cells.

IT is a monoclonal antibody used in conjunction with radioactive medications to treat non-Hodgkin's lymphoma patients who have relapsed after treatment or for those with slow-growing forms of the disease such as follicular lymphoma. While there have been studies to investigate the usefulness of PET in patients with lymphoma and research into the effectiveness of radioimmunotherapy, no data were available regarding the role of PET in determining whether patients would be good candidates for IT.

In their study, Fanti and his team examined 38 non-Hodgkin's lymphoma patients who were treated with IT after a relapse. PET scans were taken before IT treatment and then three months after treatment began. All patients had a final assessment at six months using clinical data.

Results indicated that the first set of PET scans detected the relapse and extent of the disease in all of the patients. At the six-month follow up, 89 percent of the patients were either in complete or partial remission after the IT treatment. Comparison of PET data on the extent of patients' disease at relapse and their response after three months indicated a higher rate of response to the treatment in patients whose cancer was limited. In all of the cases, the findings of the PET scans at three months were consistent with the clinical findings at six months.


'/>"/>

Contact: Amy Shaw
ashaw@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related medicine news :

1. Kellogg and MyPyramid - Helping Families Live Well Today and Every Day
2. Finally ... A Pure and Perfect Multi-Vitamin for Every Kid
3. Man who Lost Everything Comes to Detroit to Spread Message of Hope
4. Everybody in the Club Scream O!
5. AIDS Action Urges Everyone to Help End the AIDS Epidemic by Being Part of the Search for an HIV Vaccine
6. Varenna Translates Resort Living Into Everyday Senior Living
7. New Supplement Helps Americans Eat Less Every Day
8. UNICEF: Every Second Can Make a Difference to Myanmars Children; 20% Already Suffering from Diarrhea, Malaria reported
9. Natural Solutions May Issue Illustrates Cocktail Effect of Everyday Toxins; Offers Tips to Reduce Toxic Load
10. 10% of U.S. Kids Using Cough Medicine Every Week
11. Every fifth adolescent smokes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
(Date:10/13/2017)... ... 2017 , ... “America On The Brink”: the Christian history of the United ... the creation of published author, William Nowers. Captain Nowers and his wife, Millie, ... spent thirty years in the Navy. Following his career as a naval aviator ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... now treating sleep apnea using cutting-edge Oventus O2Vent technology. As many ... sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer significant ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... products to meet the demand of today’s consumer and regulatory authorities worldwide. From ... probiotic experts and tested to meet the highest standard. , These products ...
(Date:10/12/2017)... , ... October 12, 2017 , ... The American College ... to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in ... , In honor of Morris F. Collen, a pioneer in the field of medical ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017  Eli Lilly and Company (NYSE: ... for the third quarter of 2017 on Tuesday, October ... on that day with the investment community and media ... The conference call will begin at 9 a.m. Eastern ... a live webcast of the conference call through a ...
(Date:9/28/2017)... Sept. 28, 2017 Hill-Rom Holdings, Inc. (NYSE: ... conference call and webcast on Friday, November 3, 2017, ... and ending at approximately 8:30 a.m. (CDT) / 9:30 ... company,s 2017 financial performance and guidance for 2018, Hill-Rom ... to enhance operational performance, and long-range financial outlook through ...
(Date:9/25/2017)... 2017   Montrium , an industry leader ... the IQPC Trial Master Files & Inspection Readiness ... EastHORN Clinical Services has selected eTMF Connect ... management. EastHORN, a leading European contract research organization ... transparency to enable greater collaboration with sponsors, improve ...
Breaking Medicine Technology: