Navigation Links
Every patient is unique: Individualized therapies for non-Hodgkin's lymphoma
Date:6/16/2008

NEW ORLEANS, La.Positron emission tomography (PET) could be an important tool for identifying non-Hodgkin's lymphoma patients who are likely to respond well to treatment with 90 ibritumomab tiuxetan (IT)the first radioimmunotherapy treatment approved for use by the U.S. Food and Drug Administration, said researchers at SNM's 55th Annual Meeting. PET imaging allows practitioners to identify patients who could be treated, predict how they would respond and identify relapses early in patients who have follicular lymphoma, a common type of slow-growing lymphoma.

"This study illustrates how PET could be used to advance the goal of personalized medicineidentifying and targeting the right treatment for each individual," said Stefano Fanti, professor of nuclear medicine at the Policlinico S. OrsolaUniversit di Bologna in Bologna, Italy, and a researcher of this study. "The functional data provided by PET are essential for determining stages of cancer, detecting disease relapses and evaluating how patients respond to particular therapies. Our study clearly indicates that the next stepusing PET for predicting how patients will respond to treatmentcan be achieved."

In the United States, about 65,000 new cases of non-Hodgkin's lymphoma are diagnosed every year. The number of new cases is on the rise, especially among older people and people whose immune systems are not functioning normally. Those at risk include people who have had organ transplants and those with human immunodeficiency virus (HIV).

Non-Hodgkin's lymphomas are a diverse group of cancers that develop in B or T lymphocytes, which are white blood cells that normally defend the body against bacteria and other pathogens. This group of cancers is actually the cause of more than 20 diseases, which have distinct appearances under the microscope and different clinical courses. Most non-Hodgkin's lymphomas are from B cells.

IT is a monoclonal antibody used in conjunction with radioactive medications to treat non-Hodgkin's lymphoma patients who have relapsed after treatment or for those with slow-growing forms of the disease such as follicular lymphoma. While there have been studies to investigate the usefulness of PET in patients with lymphoma and research into the effectiveness of radioimmunotherapy, no data were available regarding the role of PET in determining whether patients would be good candidates for IT.

In their study, Fanti and his team examined 38 non-Hodgkin's lymphoma patients who were treated with IT after a relapse. PET scans were taken before IT treatment and then three months after treatment began. All patients had a final assessment at six months using clinical data.

Results indicated that the first set of PET scans detected the relapse and extent of the disease in all of the patients. At the six-month follow up, 89 percent of the patients were either in complete or partial remission after the IT treatment. Comparison of PET data on the extent of patients' disease at relapse and their response after three months indicated a higher rate of response to the treatment in patients whose cancer was limited. In all of the cases, the findings of the PET scans at three months were consistent with the clinical findings at six months.


'/>"/>

Contact: Amy Shaw
ashaw@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related medicine news :

1. Kellogg and MyPyramid - Helping Families Live Well Today and Every Day
2. Finally ... A Pure and Perfect Multi-Vitamin for Every Kid
3. Man who Lost Everything Comes to Detroit to Spread Message of Hope
4. Everybody in the Club Scream O!
5. AIDS Action Urges Everyone to Help End the AIDS Epidemic by Being Part of the Search for an HIV Vaccine
6. Varenna Translates Resort Living Into Everyday Senior Living
7. New Supplement Helps Americans Eat Less Every Day
8. UNICEF: Every Second Can Make a Difference to Myanmars Children; 20% Already Suffering from Diarrhea, Malaria reported
9. Natural Solutions May Issue Illustrates Cocktail Effect of Everyday Toxins; Offers Tips to Reduce Toxic Load
10. 10% of U.S. Kids Using Cough Medicine Every Week
11. Every fifth adolescent smokes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... , ... May 04, 2016 , ... Natalie Jill ... with local company MitoXcell in preparation of the launch of her new book: Natalie ... plan is a nutritional guide designed to jump start a new healthy lifestyle featuring ...
(Date:5/4/2016)... ... May 04, 2016 , ... Advanced Spine & Sport Medical Rehabilitation Center, which ... is hosting a free seminar on stem cell injections. The seminar is scheduled for ... Sport, 4601 Telephone Road, Suite 110, Ventura, CA. There are only 10 seats available. ...
(Date:5/4/2016)... British Columbia – , ... ... Wimmzi , a manufacturer of innovative infant and child products, today ... toys. But their ability to help babies deal with teething pain ... FDA approved, contain no toxic gels, and are BPA-, PVC-, and ...
(Date:5/4/2016)... ... 2016 , ... Over 40 athletic trainer’s (ATs) and athletic training students (ATSs) ... “Hike to Harrisburg” advocacy day. The annual lobbying effort is a collaboration between ... The goal for the day was to educate the elected legislators and the public ...
(Date:5/4/2016)... ... May 04, 2016 , ... Netc , a leading provider of barcode ... Style Printing, Inc. The Dataware acquisition enables Netc to continue to grow its label business, ... Label Stock provides customers with the ability to print and label tape media on site ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... TUSTIN, Calif. , May 3, 2016 /PRNewswire/ ... science teaching tool that shows how a cleanroom ... for classroom discussions about science and technology. ... Manager said, "As a technology company, SSF enthusiastically ... program to help educators foster the next generation ...
(Date:5/3/2016)... May 3, 2016 ... dass sie einen entscheidenden Meilenstein durch diese ... Aufruf zum Handeln, um Patientenresultate  bei Verdauungs- ... zu Fortschritten im Verständnis der Hepatischen Enzephalopathie ... Bewusstsein für Hepatische Enzephalopathie in der Öffentlichkeit ...
(Date:5/2/2016)... , May 2, 2016  While nearly three-quarters ... osteoporosis can have on their health, only about half ... according to the results of a new survey announced ... mark the start of National Osteoporosis Month, Hologic is ... which affects nearly 56 million Americans. Osteoporosis ...
Breaking Medicine Technology: