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Even tiny breast tumors can be aggressive and may require maximum therapy
Date:12/17/2007

s. Chemotherapy may not work as well as we would like in these tumors, but, still, physicians who treat patients with triple negative cancer should be aware of the higher risk of relapse, even if tumors are quite small, she says.

Adjuvant chemotherapy was offered to 28 percent of patients with HER2+ tumors, and only 4 percent received the targeted therapy Herceptin, which has been designed specifically to treat this class of tumors. Should Herceptin be offered to such small node-negative tumors" There is not enough data currently to answer this question, Dr. Amar says. But this study definitely highlights the fact that HER2 positive tumors, even if very small, may warrant more aggressive therapy.

Only 3.9 percent of patients with HER2 neg/ER/PR+ cancer were treated with chemotherapy. So although the rates of adjuvant chemotherapy use were significantly higher in the HER2+ and triple negative subgroups, these groups still showed a higher relapse rate, she says.


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Contact: Paul Scotti
scotti.paul@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

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