Navigation Links
Even low-dose aspirin may increase risk of GI bleeding
Date:9/12/2011

The risk of gastrointestinal (GI) bleeding needs to be considered when determining the potential preventive benefits associated with low-dose aspirin for cardiovascular disease and cancer. According to a new study in Clinical Gastroenterology and Hepatology, the use of low-dose aspirin increases the risk for GI bleeding, with the risk being increased further with accompanying use of cardiovascular disease-preventing therapies, such as clopidogrel and anticoagulants. In patients who took proton pump inhibitors (PPIs), bleeding risk decreased. Clinical Gastroenterology and Hepatology is the official journal of the American Gastroenterological Association.

"The use of aspirin has been proven beneficial in reducing cardiac events and deaths in patients who have cardiovascular disease, and has even been shown to reduce cancer risk," said Angel Lanas, MD, PhD, of University Hospital Lozano Blesa and lead author of this study. "However, clinicians need to be more proactive in their efforts to reduce potential risk factors associated with all doses of aspirin, especially gastrointestinal bleeding. New low-dose aspirin studies should report more precisely on the incidence of bleedings, especially gastrointestinal bleedings, to better determine the balance between risks and benefits ."

Low-dose aspirin commonly defined as 75 to 325 mg daily is a mainstay of therapy for cardiovascular disease. In fact, patients with prior cardiovascular disease have fewer cardiovascular events and deaths with the use of low-dose aspirin compared with patients who do not use it. It is now likely to also be used for cancer prevention, especially GI and colon cancer.

A major factor limiting the widespread use of aspirin is concern about the development of GI adverse events, especially GI bleeding. However, damage may vary depending on the dose taken, other medication being consumed along with aspirin and patients' risk profiles. For example, certain patients have an increased likelihood of experiencing bleeding: those with long-term pharmacotherapy use, patients using combinations of low-dose aspirin with clopidogrel and anticoagulants, and patients with previous GI ulcers or bleedings.

In this study, doctors searched 10 electronic databases and collected data on adverse events in studies that evaluated low doses of aspirin alone or in combination with anticoagulants, clopidogrel or PPIs. They found that low doses of aspirin alone decreased the risk of death. However, the risk of major GI bleeding increased with low doses of aspirin alone compared with placebo. The risk also increased when aspirin was combined with clopidogrel (compared with aspirin alone), anticoagulants versus low doses of aspirin alone, or in studies that included patients with a history of GI bleeding or of longer duration. Importantly, PPI use reduced the risk for major GI bleeding in patients given low doses of aspirin.


'/>"/>

Contact: Alissa J. Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

Related medicine news :

1. Low-Dose Platelet Transfusions Deemed Safe
2. Low-Dose HRT Patch May Lessen Stroke Risk
3. Low-Dose Omega-3 Fatty Acids Dont Protect Heart Patients
4. Low-Dose Aspirin May Reduce Colon Cancer Risk
5. Low-dose aspirin reduces death rates from range of cancers by between 20 and 30 percent
6. Low-Dose Aspirin Boosts Accuracy of Colon Cancer Test
7. Small bowel blood flow in healthy subjects receiving low-dose aspirin
8. Risk of cancer increases with exposure to low-dose radiation
9. Low-dose chest CT effective in reducing radiation for evaluation of cardiothoracic surgery patients
10. Low-dose sorafenib may improve therapy for head and neck cancer
11. New Blood Thinner Beats Plavix When Paired With Low-Dose Aspirin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... 08, 2016 , ... Vida Health, the digital health platform that ... Canvas Ventures . Other investors include Nokia Growth Partners (NGP) and returning investor ... more consumers who are managing chronic conditions or simply want to improve ...
(Date:12/8/2016)... Cincinnati, OH (PRWEB) , ... December 08, 2016 ... ... offering insurance and financial planning services from offices headquartered in Hamilton County, is ... animal rescue LuvFurMutts. , LuvFurMutts specializes in finding new homes for orphaned or ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... that serve communities in and around the greater Phoenix metropolitan region, is announcing ... Connection. , The mission of the Homeless Youth Connection is to promote community ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Compretta Insurance Agency, a ... clients in and around the Hancock County area, is announcing the launch of a ... Pantry. , The Hancock County Food Pantry has worked for more than 30 years ...
(Date:12/8/2016)... ... 2016 , ... Bill Mull Agencies, a Wichita-based firm offering ... central Kansas, is joining the Youth Horizons organization for a charity event that ... Wichita, Youth Horizons works to empower area children from unstable, troubled, or single-parent ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... Dec. 8, 2016 True Health Diagnostics ... leading-edge laboratory services and management expertise to hospital ... , allowing more doctors and patients to benefit ... solutions. Logo - http://photos.prnewswire.com/prnh/20161208/447162LOGO ... systems, under pressure to contain costs, have struggled ...
(Date:12/8/2016)... Inc . hat die behördliche Zulassung durch die CFDA sowie die Produkteinführung ... China angekündigt. ... ... Live Stretta procedure performed and broadcast during the Chinese Congress of Digestive ... , ...
(Date:12/8/2016)... 8, 2016 Dignitana, a world leader in ... Boa® Technology, creator of the award-winning, patented Boa® system, ... with the DigniCap® scalp cooling system. DigniCap® was cleared ... 2015, and is the first medical scalp cooling device ... cooling system features a patented tight-fitting silicone cooling cap ...
Breaking Medicine Technology: