Navigation Links
European Researchers Find Genes Tied to Asthma
Date:9/23/2010

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, Sept. 22 (HealthDay News) -- European scientists have identified genes that predispose children and adults to asthma.

Some of the genes tell the immune system when the lining of the airways has been damaged. Others may control healing of the airways after they have been injured, the researchers said.

"But the genes are different genes for children than for adults," said study coauthor Dr. Erika von Mutius, a professor of pediatrics at University Children's Hospital in Munich, Germany.

"However, even if we have been able to identify a number of these genes, we cannot predict disease just based on these genes because other factors, including environmental factors, are important as well," she added. "The genes do not explain everything."

The report is published in the Sept. 23 issue of the New England Journal of Medicine.

For the GABRIEL study, von Mutius and colleagues from London, Paris, Munich and Oxford looked at genes from 10,365 asthmatics and compared them with the genes of 16,110 people without asthma.

After looking at all the genes in these individuals, the researchers found some new genes that predispose people to asthma. Among adults, the effect of genes in the development of asthma was weaker than in children.

Among children, the most important gene linked to asthma is called ORMDL3/GSDMB, and is not involved in adults who develop asthma, von Mutius and colleagues found.

These newly identified gene variants affected more than one-third of children with asthma. In addition, these genes had strong effects on severe asthma, the study authors noted.

However, despite these findings, genetic testing would be of no value in predicting early in life which children might eventually develop asthma, because environmental factors are also important for asthma to develop, von Mutius said.

These scientists are working to identify environmental causes that can trigger asthma, she added.

However, the researchers suggested that the identification of these genes might one day lead to better treatments for asthma.

The researchers also looked at genes that control antibodies linked to allergies. However, these genes had little effect on the presence of asthma, and the asthma genes had little effect on the levels of antibodies, which means, they said, that the allergies that often accompany asthma are most likely a consequence of the asthma not its cause.

Dr. Norman H. Edelman, chief medical officer at the American Lung Association, called the study "very well done." He added, "Its most critical attribute is the large number of subjects and genes studied, allowing for good confidence in conclusions about lack of association as well as association with candidate genes."

The study is also important, he said, because it found several aspects of asthma that have been suspected but not proven.

For example, "there are many key differences between adult- and childhood-onset asthma. They probably should be considered to be different diseases," Edelman said.

Also, allergy is not likely to be an important underlying cause of asthma, he added.

"There is no simple genetic basis for asthma; it seems to be the end result of many different genetic predispositions," Edelman said.

More information

For more information on asthma, visit the U.S. National Institutes of Health.

SOURCES: Erika von Mutius, M.D., professor, pediatrics, University Children's Hospital, Munich, Germany; Norman H. Edelman, M.D., chief medical officer, American Lung Association, and professor, preventive medicine, internal medicine, physiology and biophysics, Stony Brook University, Stony Brook, N.Y.; Sept. 23, 2010, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. European partnership funds research toward robot aides for the elderly
2. New case series section in European Urology
3. European Society of Cardiology launches heart-friendly cookery book
4. New impact factor of European Urology underlines journals outstanding position
5. European patient survey add weight to expert call for greater clinical consensus on BTCP
6. European Urology: Editorial about REDUCE trial underlines value of dutasteride
7. Third European Novel Food Approval Received by Tahitian Noni International
8. HCL Thames Medics says more locum doctors could help address European Working Time Directive shortage
9. European collaboration seeks to create World Wide Web for robots
10. European hematologist receives award to conduct research in US
11. The European Medicines Agency Completes Validation Stage for InterMunes Marketing Authorization Application for pirfenidone
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
European Researchers Find Genes Tied to Asthma 
(Date:1/24/2017)... ... January 24, 2017 , ... This Saturday, January 28, the ... a very special performance by Alabama Symphony Orchestra musicians Yifan Zhou, Mara McClain & ... as dim sum, and exhibitors offer a look at Chinese games, crafts & more. ...
(Date:1/24/2017)... ... January 24, 2017 , ... The NewKILO JRP, a three-year ... and co-funded by the European Union (EU), was completed in May 2015. The future ... being maintained and used in air, which presents some challenges to establishing traceability to ...
(Date:1/24/2017)... ... January 24, 2017 , ... TopConsumerReviews.com recently gave a ... premenstrual syndrome, or PMS . , Most women of child-bearing age will experience ... constipation, irritability, headaches, fatigue, and other discomfort. For some women, the effects ...
(Date:1/24/2017)... , ... January 24, 2017 , ... “Mysteries Revealed On ... be a mysterious phenomenon is available to all Christians. “Mysteries Revealed On Speaking In ... of “U Beautiful Creation,” a Christian-based talk show located in Michigan. , “We ...
(Date:1/24/2017)... ... January 23, 2017 , ... The Pharmacy and Medically ... the bipartisan original co-sponsorship of nearly one-quarter of the U.S. House of Representatives. ... of Chain Drug Stores (NACDS) strongly backs the legislation. , “NACDS thanks for ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... SPRINGFIELD GARDENS, N.Y. , Jan. 23, 2017 /PRNewswire/ ... an object from a blocked airway and prevented choking ... and disability awareness advocate to the LifeVac team as ... to have Steve join the LifeVac team," said ... is uniquely positioned to represent LifeVac and his mission ...
(Date:1/23/2017)... 23, 2017 7D Surgical announced today ... the U.S. Food and Drug Administration (FDA) and ... the North American commercial launch of its innovative ... surgery, the 7D Surgical System.  ... technologies and machine vision algorithms to eliminate the ...
(Date:1/23/2017)... -- Allergan plc, (NYSE: AGN ), a leading global ... Headache Academy (IHA). Designed to inspire a long-term commitment to ... a three-day, intensive overview on research and treatment options. This ... sponsor since the inception of IHA in North ... Europe in 2014. "Allergan is ...
Breaking Medicine Technology: