Navigation Links
European Researchers Find Genes Tied to Asthma
Date:9/23/2010

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, Sept. 22 (HealthDay News) -- European scientists have identified genes that predispose children and adults to asthma.

Some of the genes tell the immune system when the lining of the airways has been damaged. Others may control healing of the airways after they have been injured, the researchers said.

"But the genes are different genes for children than for adults," said study coauthor Dr. Erika von Mutius, a professor of pediatrics at University Children's Hospital in Munich, Germany.

"However, even if we have been able to identify a number of these genes, we cannot predict disease just based on these genes because other factors, including environmental factors, are important as well," she added. "The genes do not explain everything."

The report is published in the Sept. 23 issue of the New England Journal of Medicine.

For the GABRIEL study, von Mutius and colleagues from London, Paris, Munich and Oxford looked at genes from 10,365 asthmatics and compared them with the genes of 16,110 people without asthma.

After looking at all the genes in these individuals, the researchers found some new genes that predispose people to asthma. Among adults, the effect of genes in the development of asthma was weaker than in children.

Among children, the most important gene linked to asthma is called ORMDL3/GSDMB, and is not involved in adults who develop asthma, von Mutius and colleagues found.

These newly identified gene variants affected more than one-third of children with asthma. In addition, these genes had strong effects on severe asthma, the study authors noted.

However, despite these findings, genetic testing would be of no value in predicting early in life which children might eventually develop asthma, because environmental factors are also important for asthma to develop, von Mutius said.

These scientists are working to identify environmental causes that can trigger asthma, she added.

However, the researchers suggested that the identification of these genes might one day lead to better treatments for asthma.

The researchers also looked at genes that control antibodies linked to allergies. However, these genes had little effect on the presence of asthma, and the asthma genes had little effect on the levels of antibodies, which means, they said, that the allergies that often accompany asthma are most likely a consequence of the asthma not its cause.

Dr. Norman H. Edelman, chief medical officer at the American Lung Association, called the study "very well done." He added, "Its most critical attribute is the large number of subjects and genes studied, allowing for good confidence in conclusions about lack of association as well as association with candidate genes."

The study is also important, he said, because it found several aspects of asthma that have been suspected but not proven.

For example, "there are many key differences between adult- and childhood-onset asthma. They probably should be considered to be different diseases," Edelman said.

Also, allergy is not likely to be an important underlying cause of asthma, he added.

"There is no simple genetic basis for asthma; it seems to be the end result of many different genetic predispositions," Edelman said.

More information

For more information on asthma, visit the U.S. National Institutes of Health.

SOURCES: Erika von Mutius, M.D., professor, pediatrics, University Children's Hospital, Munich, Germany; Norman H. Edelman, M.D., chief medical officer, American Lung Association, and professor, preventive medicine, internal medicine, physiology and biophysics, Stony Brook University, Stony Brook, N.Y.; Sept. 23, 2010, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. European partnership funds research toward robot aides for the elderly
2. New case series section in European Urology
3. European Society of Cardiology launches heart-friendly cookery book
4. New impact factor of European Urology underlines journals outstanding position
5. European patient survey add weight to expert call for greater clinical consensus on BTCP
6. European Urology: Editorial about REDUCE trial underlines value of dutasteride
7. Third European Novel Food Approval Received by Tahitian Noni International
8. HCL Thames Medics says more locum doctors could help address European Working Time Directive shortage
9. European collaboration seeks to create World Wide Web for robots
10. European hematologist receives award to conduct research in US
11. The European Medicines Agency Completes Validation Stage for InterMunes Marketing Authorization Application for pirfenidone
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
European Researchers Find Genes Tied to Asthma 
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... ... 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 ... by their peers for this recognition are considered among the top 2 percent of ... honors as members of this year’s Legal Elite Hall of Fame: Miami Shareholders ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
(Date:6/24/2016)... ... 2016 , ... Strategic Capital Partners, LLC (SCP) in concert ... capital for emerging technology companies. SCP has delivered investment events and professional ... than a million dollars of capital investment for five companies. The ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... supporting the upcoming 2016 Miss Arizona pageant as its official Medspa Sponsor. Dr. ... Tempe, Mesa, and Chandler, Arizona. , Dr. Olson says the decision to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Analysis 2016 - Forecast to 2022" report to their ... contains up to date financial data derived from varied research ... trends with potential impact on the market during the next ... which comprises of sub markets, regional and country level analysis. ...
(Date:6/23/2016)... , June 23, 2016 Bracket , ... launch its next generation clinical outcomes platform, Bracket eCOA (SM) ... held on June 26 – 30, 2016 in ... first electronic Clinical Outcome Assessment product of its kind to ... #715. Bracket eCOA 6.0 is a flexible platform ...
(Date:6/23/2016)... NORTHBROOK, Ill. and BOGOTA, Colombia , June 23, 2016  Astellas today announced the ... joins Astellas Farma Brasil as the company,s second affiliate in Latin America . ... ... appointed General Manager of Astellas Farma Colombia ... ...
Breaking Medicine Technology: