Navigation Links
EuroPCR 2014 examines vascular response and long-term safety of bioresorbable scaffolds
Date:5/22/2014

22 May 2014, Paris, France: At EuroPCR 2014 yesterday, experts discussed the development in evidence for bioresorbable vascular scaffolds, which represent an era of vascular restoration in interventional cardiology. The available data were analysed and participants heard that bioresorbable fixed strut vascular scaffolds are associated with increased acute thrombogenicity due to flow disturbances. This means that patients who are implanted with these devices need to receive ongoing dual antiplatelet therapy, and the strategy is under discussion. The panellists also pointed out that endothelialisation is further delayed when these devices are used compared with when thin strut drug-eluting stents are used.

Tan Huay Cheem, National University Heart Centre, Singapore, said: I think one of the greatest attractions of bioresorbable vascular scaffolds is the idea that normal vasofunction will eventually be restored. There is some evidence from imaging data to show that the plaque is modified alongside the stent dissolving. There is also positive remodelling taking place, and this vascular response is one of the most exciting aspects of the technology.

The diversity of devices that are approaching the market was also emphasised. Michael Joner, CEO, CVPath Institute, Gaithersburg, USA, said: There is no uniformity in these devices and no class effect. Every device needs to be assessed carefully and individually. The inflammatory response associated with these devices depends on the pace of degradation, so we need to assess how they degrade over time, and this has important implications for patient safety.

The long-term safety of bioresorbable vascular scaffolds will depend on various things: if we can see that arterial healing occurs over time; if full degradation occurs in the absence of excess inflammation and if we do not see too much positive remodelling, then these devices can be very beneficial to patient care, Joner added.

I think the technology is very interesting, but the bar that has been set by drug-eluting stents is very high and bioresorbable vascular scaffolds will need to match this, especially with regard to strut thickness and deliverability, said Prof Chaim Lotan, Head of the Cardiovascular Insitute, Hadassah University Hospital, Jerusalem, Israel.

Lotan also commented on the lack of long-term safety data being available. We need follow-up data of more than five years duration, possibly up to 10 years, because our previous experience with bare metal stents and drug-eluting stents has shown that we still see changes up to seven years. So we await long-term data for bioresorbable vascular scaffolds with regard to device behaviour and degradation patterns. We have seen cases where the stent has not yet degraded after three years and this could pose a problem for patients. Will the degradation occur as planned? Will the struts be apposed? Will we see late events such as thrombosis? All these are unanswered questions, he said.

Robert-Jan van Geuns, University of Rotterdam, The Netherlands, pointed to the potential advantages of using bioresorbable vascular scaffolds. In general, the data emerging are in line with the theory behind these devices: that vascular restoration therapy is going to heal vessels better than metallic stents. The long-term data has been demonstrated in non-complex patients, and we see that these patients do very well. We still need more data in more complex patients; there are now some non-randomised data available that are out to six-months, but we have to wait for the evidence in more complex patients before we can advocate the use of these devices in such patients, he said.


'/>"/>

Contact: Isabelle Uzielli
iuzielli@europcr.com
EuroPCR
Source:Eurekalert

Related medicine news :

1. CRF will Provide updates on several key cardiovascular trials at EuroPCR
2. New ESC-EACTS guidelines on myocardial revascularization to be released at EuroPCR 2014
3. EuroPCR 2014 showcases technological advances in complex cardiovascular interventions
4. Personalizing revascularization strategy for STEMI patients is vital, EuroPCR panel finds
5. EuroPCR 2014 examines whether science translates into practice with new session format
6. Study examines medicare use for Mohs micrographic surgery and surgical excision for skin cancer
7. Study examines drug regimen for the treatment of non-small cell lung cancer among older patients
8. Study examines adverse effects among different radiation therapies for prostate cancer
9. LA BioMeds Dr. John Tsuang examines effects of Ibudilast and metamphetamines
10. Study examines benefit of follow-up CT when abdominal ultrasound inconclusive
11. Research examines when benefits of screening mammography outweigh the harms for women in their 40s
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. ... his M.D from the David Geffen School of Medicine at UCLA. He trained in ... to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
(Date:6/24/2016)... , June 24, 2016  American Respiratory Labs (ARL), a ... now able to perform sophisticated lung assessments in patients, homes, thanks ... Inc. Patients are no longer limited to having ... PRO ® , ARL patients like Jeanne R. of ... the comfort of her own home. ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
Breaking Medicine Technology: