Navigation Links
Ethiopians and Tibetans thrive in thin air using similar physiology, but different genes
Date:12/7/2012

nd some in Ethiopia, for example, are able to maintain relatively low blood hemoglobin concentrations at high altitude compared to their counterparts in the Andes, a trait that makes them less susceptible to chronic mountain sickness.

Tibetans and some Ethiopians have both evolved a dampened response to low oxygen, explained study co-authors Anna Di Rienzo and Gorka Alkorta-Aranburu of the University of Chicago.

The researchers wanted to pinpoint the genetic changes that enable Ethiopians to thrive in thin air, and to see if the same genes play a role for Ethiopians as found in recent studies for Tibetans.

To find out, they analyzed the genomes of nearly 260 Ethiopian villagers belonging to two ethnic groups: the Oromo, who began settling at high altitude in the Bale Mountains of southeast Ethiopia about 500 years ago, and the Amhara, who have lived at high altitude in the Semien Mountains of northwest Ethiopia for at least 5,000 years.

Research by Beall and colleagues in the early 2000s revealed that Oromo cope with thin air in much the same way that lowlanders visiting high altitude do i.e., by making more hemoglobin.

In contrast, Amhara highlanders whose ancestors have inhabited mountainous regions for thousands of years longer than the Omoro are able to maintain blood hemoglobin levels that are roughly 10% lower than Omoro living at the same altitude.

In a study to appear in the December 6, 2012 online issue of the journal PLoS Genetics, a team led by Beall, Di Rienzo and Alkorta-Aranburu analyzed both groups' DNA, which was extracted from blood and saliva samples donated by Amhara and Omoro villagers born and raised at high (3700-4000m) and low (1200-1560m) elevations.

Using a statistical technique called a genome-wide association study, the researchers scanned the genomes of highland and lowland Ethiopians from both ethnic groups in search of variants associated with hemoglobin levels
'/>"/>

Contact: Robin Ann Smith
rsmith@nescent.org
919-668-4544
National Evolutionary Synthesis Center (NESCent)
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Seniors Creativity Can Thrive Despite Dementia
2. Parents Can Adapt, Thrive After Empty Nest
3. Prenatal tests more informative using microarray technology, find GW researchers
4. Arizona Dental Heights Moves to Using the New Nomad Pro Hand Held X-Ray System
5. The US Drug Watchdog Now Urges Women Who Suffered A Heart Attack Or Stroke After Using Yaz Yasmin Birth Control Pills To Contact The Johnson Law Group Immediately
6. Using an HRA to Comply with San Francisco's HCSO Requirements - Zane Benefits Publishes Information
7. Diabetes Rates Higher in Countries Using Lots of High Fructose Corn Syrup: Study
8. Targeting downstream proteins in cancer-causing pathway shows promise in cell, animal model
9. Housing quality associated with childrens burn injury risk
10. Understanding antibiotic resistance using crystallography and computation
11. Using Canadas Health System as Model Might Cut U.S. Costs: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... Targeted therapies, made possible by ... of patients, according to a newly published report. Surviving Mesothelioma has more on ... , The authors of the new paper focus on several types of ...
(Date:8/29/2015)... (PRWEB) , ... August 29, 2015 , ... ProDrop Particles ... . Each preset contains 15 seconds of unique footage that users can shrink and ... fall, zoom, attract and more. Users can customize color, brightness, scale, speed, range, and ...
(Date:8/29/2015)... ... August 29, 2015 , ... Vascular Health ... and sell Arterosil and Arterosil HP, and that all claims and counterclaims have ... Health Sciences, LLC (VHS) in the United States District Court for the Southern ...
(Date:8/28/2015)... ... August 28, 2015 , ... Approximately 2,000 United ... to celebrate children helping children, a thank you to the many creative and ... contributed to the United Methodist initiative to end malaria deaths. , The Columbus ...
(Date:8/28/2015)... , ... August 28, 2015 , ... For Dallas, the ... taking part with their subsidiary USPI Tenet Health. , The American Heart Association hosts ... disease and stroke. They believe that together, a difference can be made. Walkers can ...
Breaking Medicine News(10 mins):Health News:Top Mesothelioma Researchers Highlight Targeted Therapies in New Report, According to Surviving Mesothelioma 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2
... HealthDay Reporter , WEDNESDAY, Feb. 23 (HealthDay News) -- ... be attached to a smart phone and diagnose cancerous ... The so-called microNMR chip, which uses magnetic nanoparticles to ... only tiny amounts of tissue to make a diagnosis, ...
... Diego are developing nonsurgical methods for identifying critical lymph ... breast cancer patients. The "sentinel lymph node" is routinely ... that the cancer has spread beyond the breast. ... Department of Nanoengineering in the UC San Diego Jacobs ...
... , WEDNESDAY, Feb. 23 (HealthDay News) -- ... high blood levels of a stress-related hormone, new research ... (PACAP) -- is known to affect central nervous system ... In the new study, published in the Feb. ...
... for schizophrenia research, an international team of scientists led by ... involving Trinity College Dublin researchers has identified a gene mutation ... target for the development of drug therapies. The findings are ... Nature . Schizophrenia is a chronic, severe and ...
... The main active ingredient in marijuana seems to allow chemotherapy ... according to the results of a small new study. ... cancer patients restore their appetite. Chemotherapy patients often lose ... them to lose an unhealthy amount of weight. Researchers at ...
... HOUSTON - While studying one tumor-suppressing protein, Cheryl Walker,s ... Cancer Center came across a separate surprise. They found ... nucleus moonlighting out in the cell,s cytoplasm. Following ... nuclear protein ATM has a second job controlling and ...
Cached Medicine News:Health News:Microchip Spots Cancerous Tumors Within an Hour, Study Shows 2Health News:Microchip Spots Cancerous Tumors Within an Hour, Study Shows 3Health News:Microbubbles to light the way to sentinel lymph nodes of breast cancer patients 2Health News:Discovery of new gene mutation in schizophrenia offers a new target for drug therapies 2Health News:Pot Ingredient May Restore Appetite After Chemo 2Health News:UT MD Anderson discovery wins 2010 Cozzarelli Prize 2
(Date:8/28/2015)... 28, 2015 Research and ... the "Investigation Report on China,s Bevacizumab Market ,2010-2019" ... Roche under the trade name of Avastin, bevacizumab injection ... Feb.26, 2010, it was approved by CFDA to treat ... China all come from Roche and ...
(Date:8/28/2015)... -- Today, in final recognition of the Centers for Disease ... Contacts is sharing how to keep lens cases clean.  ... do not properly care for their lens cases are ... Most contact lens wearers understand the importance of ... is sometimes overlooked.  When proper steps to clean a ...
(Date:8/28/2015)... Aug. 28, 2015 ... addition of the "Investigation Report on China,s ... offering. Developed by Novo Nordisk, insulin ... an important drug for the treatment of diabetes. ... fast- acting insulin analog, starts working fast and ...
Breaking Medicine Technology:Investigation Report on China's Bevacizumab Market 2015-2019 21-800 Contacts Shares Tips on How to Clean Lens Cases 2China Insulin Aspart Market Report 2010-2019 - Developed by Novo Nordisk 2
... MYL ) today announced that it, along ... agreement with Warner Chilcott resolving litigation related to Femcon® ... Estradiol Tablets USP (Chewable), 0.4 mg/0.035 mg and Ferrous ... medication is an oral contraceptive. Pursuant to ...
... Oct. 19, 2011 Uroplasty, Inc. (NASDAQ: UPI ... the second quarter of fiscal 2012 ended September 30, 2011, ... Company will host a conference call to discuss these results ... (3:30 p.m. Central Time). David Kaysen, President and Chief Executive ...
Cached Medicine Technology:Mylan Announces Femcon® Fe Settlement Agreement 2Uroplasty to Issue Second Quarter 2012 Financial Results on October 27, 2011 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: