Navigation Links
Estrogen therapy helps or hurts the brain depending on reproductive status
Date:6/15/2008

Estrogen therapy may limit stroke damage if started close to, but not long after reproductive cycles are over, according to a new animal study. The results were presented Sunday, June 15, at The Endocrine Society's 90th Annual Meeting in San Francisco.

"This study suggests that estrogen treatment is not toxic per se but that its effects on the brain depend on the individual's reproductive age when therapy begins," said one of the study's authors, Farida Sohrabji, PhD, of Texas A & M Health Science Center.

In their study in rats, Amutha Selvamani, a post-doctoral associate and Dr. Sohrabji, found "that estrogen treatment is not beneficial to the brain once the animal is in an acylic state, but is effective when given earlier. This acyclic stage in animals shares similarities with the menopausal stage in women."

Since the Women's Health Initiative study found that long-term therapy with estrogen or estrogen plus progestin may increase the risk of heart attack and stroke, many women have found it difficult to decide whether to take hormone therapy at menopause. Subsequently, several researchers have speculated that the timing of estrogen treatment may be important for estrogen's effects. The authors therefore designed an animal study to determine if estrogen would be beneficial for females who are going through menopause (perimenopausal) but not for women who are postmenopausal for many years. Since it is not possible to measure "risk" in animal studies, the authors measured severity of stroke injury.

Therefore, they compared groups of female rats: mature adults and older, "acyclic" rats that no longer had reproductive cycles. The physiologic status of the older rats resembled that of a postmenopausal woman, and the other rats' status would be more similar to perimenopause, according to Sohrabji. After surgically removing the ovaries of all the rats, the researchers gave them estrogen replacement therapy (estradiol) for 3 week
'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Anti-estrogen drug therapy reduces risk of invasive breast cancer in older women
2. Previously unseen switch regulates breast cancer response to estrogen
3. Estrogen therapy increases benign breast disease risk
4. Estrogen Supplements May Raise Odds of Benign Breast Disease
5. New study finds adverse effects of estrogen replacement therapy are related to the dose
6. Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection
7. Estrogen Levels in Blood Predict Breast Cancers Return
8. Duramed Launches New Indication for ENJUVIA(TM) (Synthetic Conjugated Estrogens, B) at North American Menopause Society Annual Meeting
9. Gene May Influence Breast Cancer-Estrogen Link
10. Cholesterol byproduct blocks heart health benefits of estrogen
11. UCLA study identifies designer estrogen as potential MS drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 17, 2014 As kinship care continues ... who cannot live with their parents, emphasis on kinship ... to enhance services and supports for kinship caregivers and ... National Kinship Care Conference is being held this week ... best practice, policy, program and service development for kinship ...
(Date:9/17/2014)... Final Cut Pro X plugin developers have ... Pixel Film Studios. , “ProBlue 5k is a compilation of ... to epic,” said Christina Austin, CEO of Pixel Film Studios. ... a definite game changer.” , ProBlue 5k is the ultimate ... filmmaker ! This footage compilation of over 100 anamorphic flares ...
(Date:9/17/2014)... first-of-its-kind research study was announced today that will ... impact long-term wellness and contribute to healthy aging. ... Center and funded through a $10 million unrestricted ... Fund, WELL aims to identify lifestyle and environmental ... and wellness as they age. WELL will be ...
(Date:9/17/2014)... September 17, 2014 In its latest blog ... and believes that having family close by during a stay ... not the process is successful, is highlighting a member of ... in the lives of addicts across the country and around ... therapy can reduce the blood pressure, heart rate, and stress ...
(Date:9/17/2014)... these sound like the ideas of a ... components of an exciting new approach to imaging ... of metastatic prostate cancer, scientists at Virginia Commonwealth ... Medicine and Johns Hopkins Medical Institutions have provided ... could revolutionize doctors, ability to see tumors that ...
Breaking Medicine News(10 mins):Health News:Arizona’s Children Association Kinship Service Providers Invited to Present at the CWLA National Conference 2Health News:A New Plugin Entitled ProBlue 5k Was Released Today from Pixel Film Studios Exclusively for Final Cut Pro X 2Health News:First-ever research study examines impacts of diet and lifestyle on healthy aging 2Health News:Latest Best Drug Rehabilitation Blog Post Highlights How Dogs are Helping Addicts Recover 2Health News:New non-invasive technique could revolutionize the imaging of metastatic cancer 2Health News:New non-invasive technique could revolutionize the imaging of metastatic cancer 3
... of Economy, Vet Difficulties Demonstrate Urgency; Advances in ... Mental Health America, the country,s oldest and ... mentally healthier lives, today called for action on ... for Mental Health."To view the Multimedia News Release, ...
... Customers; Reaches 400,000 Live User Milestone; Named #1 SSO ... identity and access management (IAM) solutions are the most ... the best performance in the Company,s history. In ... new user licenses. In addition, the Company reached ...
... at the University of Texas Medical Branch at Galveston ... fever virus uses to disarm the defenses of infected ... in humans, inflicting liver damage, blindness and even death ... Rift Valley fever also afflicts cattle, goats and sheep, ...
... N.M., Feb. 17 Exagen Diagnostics, Inc., which ... for research and analytic specific reagents to clinical ... Alsobrook, Ph.D., has been named vice president and ... oversees Exagen,s day-to-day operations, company alliances and genomic ...
... Effect on Executive Function and Functional Capacity are ... According to a New Report from Decision ResourcesWALTHAM, ... the world,s leading research and advisory firms for ... drug were to receive formal regulatory approval for ...
... procedure rooms offer faster and more accurate diagnosis and ... Medical Center today announces the completion of its state-of-the-art ... Now located on the second level of the ... with three fully functional state-of-the-art catheterization labs (cath labs) ...
Cached Medicine News:Health News:Video: On 100th Anniversary, Mental Health America Declares 'It's Time for Mental Health' 2Health News:Video: On 100th Anniversary, Mental Health America Declares 'It's Time for Mental Health' 3Health News:Video: On 100th Anniversary, Mental Health America Declares 'It's Time for Mental Health' 4Health News:Sentillion Announces 2008 as the Best Year in the Company's History 2Health News:Sentillion Announces 2008 as the Best Year in the Company's History 3Health News:Scientists uncover secrets of potential bioterror virus 2Health News:Exagen Diagnostics Names John Alsobrook, Ph.D., Vice President and Chief Operating Officer 2Health News:A Drug That Receives Regulatory Approval for Cognitive Impairment Associated With Schizophrenia Would Earn a Higher Patient Share in the United States Than in Europe 2Health News:A Drug That Receives Regulatory Approval for Cognitive Impairment Associated With Schizophrenia Would Earn a Higher Patient Share in the United States Than in Europe 3Health News:St. Mary Medical Center Opens New Cardiovascular Catheterization Labs Reaffirming Role as a Regional Leader in Cardiovascular Medicine 2Health News:St. Mary Medical Center Opens New Cardiovascular Catheterization Labs Reaffirming Role as a Regional Leader in Cardiovascular Medicine 3Health News:St. Mary Medical Center Opens New Cardiovascular Catheterization Labs Reaffirming Role as a Regional Leader in Cardiovascular Medicine 4Health News:St. Mary Medical Center Opens New Cardiovascular Catheterization Labs Reaffirming Role as a Regional Leader in Cardiovascular Medicine 5
(Date:9/17/2014)... 17, 2014  Decision Resources Group finds ... eligible for biologic therapy, only a proportion ... gastroenterologists cite patients, discomfort with biological therapy ... rates, followed by cost-related issues and payer ... biologics, Janssen Biotech,s Remicade and AbbVie,s Humira ...
(Date:9/17/2014)... -- Bronstein, Gewirtz & Grossman, LLC is investigating potential ... PDL BioPharma, Inc. ("PDL BioPharma" or the "Company") (NasdaqGS: ... to contact Peretz Bronstein or his investor ... or 212-697-6484. The investigation focuses on ... federal securities laws. On September 16, 2014, ...
(Date:9/17/2014)... PRAIRIE, Minn. , Sept. 17, 2014 ... and global market leader of advanced imaging modalities for ... Ultrasound System in two live cases at the Transcatheter ... The cases were presented from Medstar Washington Hospital ... York-Presbyterian Hospital/Columbia University Medical Center ( New York, ...
Breaking Medicine Technology:The Majority of Surveyed Gastroenterologists Agree that Biologics Should be Prescribed to More Patients in the Crohn's Disease and Ulcerative Colitis Treatment Paradigm 2The Majority of Surveyed Gastroenterologists Agree that Biologics Should be Prescribed to More Patients in the Crohn's Disease and Ulcerative Colitis Treatment Paradigm 3Shareholder Alert: Bronstein, Gewirtz & Grossman, LLC Investigates claims on behalf of Investors of PDL BioPharma, Inc. --PDLI 2ACIST Launches HDi High-Definition IVUS 2ACIST Launches HDi High-Definition IVUS 3
... , JERUSALEM , Jan. ... company, announced today that it has granted Novartis an option to ... Permeability Enhancer (TPE) technology for use with certain related small molecule ... a separate but related agreement, the MPM Bio IV NVS Strategic ...
... , FRANKLIN LAKES, N.J. , Jan. 19 ... scheduled to present at the following investor conferences: , Brian Griffin ... Global Healthcare Services Conference on Monday, January 25, 2010 at ... New York ; , David B. Snow Jr. , Medco chairman ...
Cached Medicine Technology:Chiasma Grants Option to License Transient Permeability Enhancer (TPE) Technology for Small Molecule Products 2Chiasma Grants Option to License Transient Permeability Enhancer (TPE) Technology for Small Molecule Products 3Medco to Present at Upcoming Investor Conferences 2
... key clinical and economic issues of cerclage ... designed to maximize tension control while minimizing ... combines efficient instrumentation with a simple technique. ... is indicated for general orthopaedic trauma surgery ...
OmniAccess&trade Hip Retractor System sets a new standard in hip exposure. It provides constant, absolute exposure of the acetabulum during total hip arthroplasty and revision procedures....
... Many of DePuy's aggressive innovations have become ... to be equalled. The AML Total ... to efficiently address and effectively meet the ... arthroplasty. With greater than 15 years ...
The Endotrac™ System includes an Obturator, Slotted Cannula, Synovial Elevator, Ligament Probe, Ligament Rasp, Blade Handle, two Retractors and sterilizable tray. The Endotrac&trade....
Medicine Products: