Navigation Links
Estrogen therapy helps or hurts the brain depending on reproductive status
Date:6/15/2008

Estrogen therapy may limit stroke damage if started close to, but not long after reproductive cycles are over, according to a new animal study. The results were presented Sunday, June 15, at The Endocrine Society's 90th Annual Meeting in San Francisco.

"This study suggests that estrogen treatment is not toxic per se but that its effects on the brain depend on the individual's reproductive age when therapy begins," said one of the study's authors, Farida Sohrabji, PhD, of Texas A & M Health Science Center.

In their study in rats, Amutha Selvamani, a post-doctoral associate and Dr. Sohrabji, found "that estrogen treatment is not beneficial to the brain once the animal is in an acylic state, but is effective when given earlier. This acyclic stage in animals shares similarities with the menopausal stage in women."

Since the Women's Health Initiative study found that long-term therapy with estrogen or estrogen plus progestin may increase the risk of heart attack and stroke, many women have found it difficult to decide whether to take hormone therapy at menopause. Subsequently, several researchers have speculated that the timing of estrogen treatment may be important for estrogen's effects. The authors therefore designed an animal study to determine if estrogen would be beneficial for females who are going through menopause (perimenopausal) but not for women who are postmenopausal for many years. Since it is not possible to measure "risk" in animal studies, the authors measured severity of stroke injury.

Therefore, they compared groups of female rats: mature adults and older, "acyclic" rats that no longer had reproductive cycles. The physiologic status of the older rats resembled that of a postmenopausal woman, and the other rats' status would be more similar to perimenopause, according to Sohrabji. After surgically removing the ovaries of all the rats, the researchers gave them estrogen replacement therapy (estradiol) for 3 weeks. Then they induced a stroke in all the animals. A week later, the rats' brains were studied for tissue damage.

The stroke caused much more tissue damage in the acyclic older females, the authors reported. "Estrogen treatment to this group actually increased the volume of the brain that was damaged," Sohrabji said.

In the mature adult rats, however, estrogen therapy apparently reduced the area of brain damage. After the stroke all rats showed evidence of sensory and motor damage on behavioral testing, but it was more severe in the acyclic rats.

"This study supports the idea that there is a narrow window of time as a woman approaches menopause and immediately afterward where estrogen therapy may provide neuroprotective benefits," Sohrabji said.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Anti-estrogen drug therapy reduces risk of invasive breast cancer in older women
2. Previously unseen switch regulates breast cancer response to estrogen
3. Estrogen therapy increases benign breast disease risk
4. Estrogen Supplements May Raise Odds of Benign Breast Disease
5. New study finds adverse effects of estrogen replacement therapy are related to the dose
6. Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection
7. Estrogen Levels in Blood Predict Breast Cancers Return
8. Duramed Launches New Indication for ENJUVIA(TM) (Synthetic Conjugated Estrogens, B) at North American Menopause Society Annual Meeting
9. Gene May Influence Breast Cancer-Estrogen Link
10. Cholesterol byproduct blocks heart health benefits of estrogen
11. UCLA study identifies designer estrogen as potential MS drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... April 24, 2017 , ... Labs often ... it difficult for lab operators and management to assess these processes with a ... wasteful or unnecessary actions. , Created with the help of both internal ...
(Date:4/24/2017)... ... 2017 , ... “Reflections of God’s Work”: an enlightening collection of life lessons ... creation of published author, Jerri Broglin, a survivor of great loss who gained insight ... great eye-opener for those searching for answers, as we are finding the answers that ...
(Date:4/24/2017)... ... April 24, 2017 , ... Miami Periodontist ... 2017 Oral Reconstruction Foundation’s 2017 Symposium on Tissue Regeneration and Implant Dentistry held ... its annual Global Symposium at the Fontainebleau Hotel located in Miami Beach, FL. ...
(Date:4/24/2017)... ... April 24, 2017 , ... Anaconda BioMed, a ... systems for the treatment of Acute Ischemic Stroke (AIS), today announced it has ... the product advances towards regulatory and clinical phases. , "This is another important ...
(Date:4/23/2017)... ... April 23, 2017 , ... Altura ... the achievement of Cisco Select certification and SMB specialization. Altura is now ... , In earning the Select Certification, Altura fulfilled the training and exam ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017  Vanderbilt University Medical ... patients in Nashville , Tennesse have ... Esophageal Sphincter Stimulation for GERD (LESS GERD) trial. The ... provide long-term reflux control by restoring normal function to ... 65 million people in the United States ...
(Date:4/19/2017)... BOSTON , April 19, 2017  New research provides ... with advanced Parkinson,s, according to a study released today that ... 69th Annual Meeting in Boston , ... comes to the treatment of Parkinson,s disease, the oral drug ... of life and longevity. But as the disease progresses, the ...
(Date:4/18/2017)... Cogentix Medical, Inc. (NASDAQ: CGNT), a global ... and Gynecology markets with innovative and proprietary products, will ... 31, 2017 after the market close on Tuesday, May ... a conference call and webcast to discuss its financial ... at 4:30 p.m. Eastern Time (3:30 p.m. Central Time). ...
Breaking Medicine Technology: