Navigation Links
Estrogen replacement therapy speeds ovarian cancer growth, new study reports
Date:10/20/2010

Aurora, Colo. (Oct. 19, 2010) Estrogen therapy used by menopausal women causes a type of ovarian cancer to grow five times faster, according to a new study by researchers at the University of Colorado Cancer Center.

Menopausal estrogen replacement therapy (ERT) also significantly increases the likelihood of the cancer metastasizing to the lymph nodes, according to the study, which will be published in the Nov. 1 issue of Cancer Research. The study was released online Oct. 19, 2010. Cancer Research, published by the American Association for Cancer Research, is the world's largest circulation medical journal devoted specifically to cancer research.

The effect of ERT was shown in mouse models of estrogen receptor positive(ER+) ovarian cancer, which accounts for about 60 percent of all human ovarian cancer cases. Ovarian cancer is one of the deadliest cancers affecting women. This year alone, nearly 22,000 women will be newly diagnosed with ovarian cancer and an estimated 13,850 women will die from the disease, according to the National Cancer Institute.

"We showed that estrogen replacement substantially increases proliferation and risk of distant lymph node metastasis in ER+ tumors," says Monique Spillman, MD, PhD, the study's lead researcher, a gynecologic oncologist at University of Colorado Hospital and assistant professor at of obstetrics and gynecology at the University of Colorado School of Medicine.

For the first time, Spillman and her team measured ovarian cancer growth in the abdomen of mice using novel techniques for visualizing the cancer. In mice with ER+ ovarian cancer cells, which were tagged with a firefly-like fluorescent protein that allowed them to be tracked, the introduction of estrogen therapy made the tumors grow five times faster than in mice that did not receive the ERT. The risk of the cancer moving to the lymph nodes increased to 26 percent in these mice compared with 6 percent in mice that did not receive ERT.

The team also found that the estrogen-regulated genes in ovarian cancer reacted differently than ER+ genes found in breast cancer, helping to explain why current anti-estrogen therapies used with breast cancer, such as Tamoxifen, are largely ineffective against ovarian cancer.

"Breast cancer and ovarian cancer are often linked when talking about hormone replacement therapy, but we found that only 10 percent of the ER+ genes overlapped," Spillman says. "We were able to identify estrogen-regulated genes specific to ER+ ovarian cancer that are not shared with ER+ breast cancers. We believe these genes can be specifically targeted with new anti-estrogen therapies that could more effectively treat ER+ ovarian cancers."

Spillman and her team now will begin to screen current antiestrogen therapies against the newly identified ovarian cancer genes to identify the pathways and compounds that are more likely to effectively treat ER+ ovarian cancer.

This study looked at the effect of estrogen replacement therapy in mice that already possessed ER+ ovarian cancer cells. It did not test whether the estrogen replacement actually could cause the development of these cancer cells. The study also dealt only with estrogen replacement, which is linked to higher risks of ovarian cancer, not combined estrogen/progesterone therapy that is used with women who retain their uteruses.

This research is too early to draw implications for use of estrogen replacement therapy in women, Spillman cautions. "We cannot make clinical recommendations based on what is happening in mice," says Spillman, one of just eight gynecological oncologists in Colorado. "Every woman is different and needs to talk to her doctor about the decision to use hormone replacement therapy."


'/>"/>

Contact: Lynn Clark
lynn.clark@ucdenver.edu
303-724-3160
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. Tendon Injuries May Be Linked to Estrogen Levels in Female Athletes
2. Team to study health effects of botanical estrogens
3. Estrogen not associated with lung cancer incidence and mortality among postmenopausal women
4. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
5. Scientists find link between estrogen metabolism pathway and breast cancer risk
6. Researchers find key to getting estrogens benefits without cancer risk
7. Progesterone is effective for hot flash treatment and provides an alternative to estrogen
8. Estrogen-lowering drugs minimize surgery in breast cancer patients
9. Estrogen receptor status of HER2+ breast cancer correlates with response to anti-HER therapies
10. Breast cancer metastasis increases after estrogen and progestin hormone therapies, MU study finds
11. Typical Male Behavior Comes From Estrogen, Too
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... , ... September 22, 2017 , ... ... Passive House buildings, and Richard Pedranti Architect (RPA), a full-service architecture ... the strategic partner’s Solsken Line of Model Homes . Independently, Ecocor and ...
(Date:9/22/2017)... ... 22, 2017 , ... Happy Living’s mission - to improve the health and ... the entertaining and delicious worlds of theatre and wines. , After watching Scott ... to turn his play into a book. The Greener The Grass ( https://www.happyliving.com/books/the-greener-the-grass ) ...
(Date:9/22/2017)... ... 22, 2017 , ... First Choice Emergency Room , ... year anniversary of its Houston-Fallbrook facility. , “We are honored to celebrate ... of First Choice Emergency Room Houston-Fallbrook. “It has been a pleasure serving the ...
(Date:9/22/2017)... ... 22, 2017 , ... “Letters From Home”: a moving compilation of letters ... to God. “Letters From Home” is the creation of published author, John Allred, a ... of Jerry Savelle Ministries International, who has traveled and ministered on four continents. , ...
(Date:9/21/2017)... ... 21, 2017 , ... With ProSlideshow Portrait from Pixel Film Studios creating a ... select from up to two layers of subject matter along with fully customizable backdrop ... Final Cut Pro X. , With ProSlideshow Portrait each user are given ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... Sept. 7, 2017 Caris Life Sciences, ... fulfilling the promise of precision medicine, today announced ... benefits of its molecular profiling approach in guiding ... genomic profiling plus (CGP+) with Caris Molecular Intelligence ... on a molecular level, leading to more therapeutic ...
(Date:9/7/2017)... 2017   BioLife Solutions , Inc. (NASDAQ: ... clinical grade cell and tissue hypothermic storage and ... Rice , President and CEO, will be presenting at two ... & Renshaw 19 th Annual Global Investment Conference on ... Pacific time). The conference is being held at the New ...
(Date:9/6/2017)... --  PDI , a leader in infection prevention products ... session focused on the role of chlorhexidine gluconate (CHG) ... 2017 Annual Scientific Meeting of the Association for Vascular ... Phoenix Convention Center in ... also feature PDI,s Prevantics® Device Swab as ...
Breaking Medicine Technology: