Navigation Links
Estrogen reduces aggression in breast cancer
Date:2/14/2011

This release is available in Spanish.

A team of researchers at CIC bioGUNE has revealed that oestrogen can reduce the risk of breast cancer. Their work shows that oestrogen is capable of reducing the number of breast cancer stem cells, which may explain the lower aggression of the tumour and, as a consequence, the possibility of a better prognosis. The project was published in Breast Cancer Research and Treatment and the team will present the results under the auspices of the International Conference on Breast Cancer to be held in Madrid. The research combined the use of human samples and laboratory cell lines.

The identification of cancer stem cells (or tumour-initiating cells) has opened up a new perspective on breast cancer, with new hopes for treatment in the future. To date treatment against cancer was designed to reduce the mass of the tumour. Nevertheless, what has recently been discovered is that, while traditional treatment is capable of killing most of the cell mass of the tumour, the cancer stem cells are more resistant to common treatment such as chemotherapy and radiation. Thus, in order to cure the cancer with greater efficacy and definitively, it is important to find ways to eliminate cancer stem cells as well.

Oestrogen is a hormone which is not without its complexity; on the one hand it is essential for the normal development and functioning of the breast and, on the other, this same hormone induces the proliferation of cancer cells once the breast tumour has appeared, i.e. oestrogen is also a risk factor in breast cancer. However, nothing or little has been known until now about the effect of oestrogen on the tumour-initiating cells.

Over recent years highly important steps in the fight against breast cancer have been taken, notable enhancing its diagnosis, prognosis and possible treatment, giving rise to a very considerable increase in the survival rates of patients. It had also been proposed that the number of cancerous stem cells is correlated with the aggressiveness of the tumour: The greater the percentage of breast cancer stem cells, the greater the aggressiveness and the worse, thereby, its prognosis.

"To our surprise, what we have seen is that oestrogen reduces the proportion of breast stem cells which means a mechanism for explaining this better prognosis observed with tumours that express the oestrogen receptor. That is, those tumours expressing the oestrogen receptor are less aggressive, better differentiated and thus have a better prognosis", explained Ms Mara Vivanco, leader of the research team.

Ms Vivanco believes that this study presents a new functional aspect of oestrogen, due to its capacity for acting in a different way depending on cellular type.

In the opinion of the CIC bioGUNE researcher, this study "has set out the molecular bases for understanding the direct effect of oestrogen on the proportion of stem cells, whether in healthy or cancerous tissue and the fact that the oestrogen receptor is an excellent prognostic marker". Moreover, this means there is an explanation for a number of clinical observations, for example: the high levels of oestrogen in the blood of postmenopausal patients being associated with less aggressive tumours; the fact that little-differentiated tumours contain more cancerous stem cells, in turn associated with the degree of the tumour, the absence of the oestrogen receptor and low survival rate; and the observed benefit of lactation attributed to a greater differentiation in the breast.

The researchers consider that the new study represents a highly important step, opening new doors to developing tools for the prevention of breast cancer.


'/>"/>

Contact: Oihane Lakar
o.lakar@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related medicine news :

1. Anti-estrogen medication reduces risk of dying from lung cancer
2. UNC researchers investigate estrogen to prevent depression and cardiovascular disease
3. Estrogen May Play Role in Rising Rates of Head, Neck Cancer
4. Estrogen-Only Hormone Therapy May Reduce Breast Cancer Risk for Some
5. Estrogen replacement therapy speeds ovarian cancer growth, new study reports
6. Tendon Injuries May Be Linked to Estrogen Levels in Female Athletes
7. Team to study health effects of botanical estrogens
8. Estrogen not associated with lung cancer incidence and mortality among postmenopausal women
9. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
10. Scientists find link between estrogen metabolism pathway and breast cancer risk
11. Researchers find key to getting estrogens benefits without cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are ... for this recognition are considered among the top 2 percent of lawyers practicing within ... of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief ... a minimum wage raise to $12 an hour by 2020 and then adjusting it yearly ... lost value of the minimum wage, assure the wage floor does not erode again, and ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
(Date:6/24/2016)... ... 2016 , ... National recruitment firm Slone Partners is pleased to ... genomics experience, as Vice President of North American Capital Sales at HTG Molecular ... the sales team in the commercialization of the HTG EdgeSeq system and associated reagents ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 VolitionRx ... of Dr. Edward Futcher to the ... effective June 23, 2016.Dr. Futcher was also appointed ... Governance Committees.  As a non-executive member of the ... and strategic counsel to VolitionRx in connection with ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Analysis 2016 - Forecast to 2022" report to their ... contains up to date financial data derived from varied research ... trends with potential impact on the market during the next ... which comprises of sub markets, regional and country level analysis. ...
Breaking Medicine Technology: