Navigation Links
Estrogen protects women with NASH from severe liver fibrosis
Date:10/29/2013

New research suggests that estrogen protects women with nonalcoholic steatohepatitis (NASH) from severe liver fibrosis. According to the study published online in Hepatology, a journal of the American Association for the Study of Liver Diseases, men are at higher risk of more severe fibrosis compared to women prior to menopause, but liver fibrosis severity is similar in men and post-menopausal women.

Non-alcoholic fatty liver disease (NAFLD) includes a range of liver disorders from simple fatty liver to inflammation, fibrosis, and cirrhosis. With the rapid rise in obesity, diabetes and metabolic syndrome, the prevalence of NAFLDthe result of insulin resistancehas also steadily increased. In fact, studies suggest that the NAFLD prevalence is 10% to 30%, making it the most common liver disease in the U.S.

"While most NAFLD patients have a mild disease known as fatty liver or hepatic steatosis, some patients present with NASH, which is more severe and increases overall mortality," explains Dr. Ayako Suzuki with the Central Arkansas Veterans Healthcare System and University of Arkansas for Medical Sciences in Little Rock, the lead author of the present study. "Our study aim was to investigate whether gender and menopause significantly impact fibrosis severity among adult patients with NAFLD."

The research team analyzed data from 541 adults with NASH who were seen at Duke University Liver Clinics and the Duke Metabolic and Weight Loss Surgery Program. The mean age of subjects was 48 years, with 35% of the group being men, 28% pre-menopausal women and 37% post-menopausal women.

Findings indicate that 22% of the cohort had advanced fibrosis. After adjusting for known predictors of fibrosis, the risk for greater fibrosis severity in post-menopausal women and men vs. pre-menopausal women was 1.4-fold and 1.6-fold, respectively. Furthermore, when dividing the cohort at age 50, which is the average age at menopause in the US,
'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Page: 1 2

Related medicine news :

1. BUSM researchers identify genetic markers for testosterone, estrogen level regulation
2. Genetic markers for testosterone and estrogen level regulation identified
3. Maturitas publishes clinical guide on low-dose vaginal estrogens for vaginal atrophy
4. Estrogen helps keep joint pain at bay after hysterectomy
5. Estrogen plus progestin use linked with increased breast cancer incidence and mortality
6. Estrogen Level in Pregnancy May Affect Breast Cancer Risk in Daughters
7. Estrogen fuels autoimmune liver damage
8. NuvaRing Lawsuits Move Forward, as Federal Judge Rules that Plaintiffs’ Experts May Testify on “Bursts” of Estrogen Allegedly Delivered by NuvaRing, Wright & Schulte LLC
9. Exercise-related changes in estrogen metabolism may lower breast cancer risk
10. Estrogen Levels Tied to Risk for Sudden Cardiac Death in Study
11. Role of estrogen in colon cancer prevention, treatment studied at UH
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... September 22, 2014. Kessler researchers have published a ... psychoeducational wellness program in people with multiple sclerosis ... mental health, perceived stress, and pain. "Development ... individuals living with MS: Description and outcomes" was ... the International Journal of MS Care ...
(Date:9/22/2014)... 22, 2014 As concerns about ... power morcellators ( http://www.gynecaremorcellatorlawsuit.com/ ) in gynecological surgeries ... detailing the continued use of uterine morcellation by ... specifically discouraged these procedures. According to The Wall ... cancer risks associated with power morcellators are overblown, ...
(Date:9/22/2014)... Barbara Bronson Gray HealthDay ... It,s something every pregnant woman wonders: What can I do ... that taking iron supplements as prescribed may play a role ... spectrum disorder (ASD). The researchers found that mothers of ... iron supplements before and during pregnancy than those whose children ...
(Date:9/22/2014)... 22, 2014 In a continued effort ... Dodge Ram is launching an awareness campaign inspired by ... or #ffbBEC) aims to raise awareness and funds for ... an egg in the air and trying to catch ... and if a nominee does not complete the challenge ...
(Date:9/22/2014)... Researchers have developed a chip capable of ... the new system to test the effectiveness of ... system, called a tumor-microenvironment-on-chip (T-MOC) device, will allow ... and the barriers that prevent the targeted delivery ... University associate professor of mechanical engineering., Researchers are ...
Breaking Medicine News(10 mins):Health News:Power Morcellator News: Bernstein Liebhard LLP Notes New Report Detailing Continued Use of Uterine Morcellation Despite FDA Warning 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes New Report Detailing Continued Use of Uterine Morcellation Despite FDA Warning 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes New Report Detailing Continued Use of Uterine Morcellation Despite FDA Warning 4Health News:Could Low Iron Intake During Pregnancy Raise Autism Risk? 2Health News:Could Low Iron Intake During Pregnancy Raise Autism Risk? 3Health News:Blind Egg Challenge Raises Awareness for Foundation Fighting Blindness 2Health News:New chip promising for tumor-targeting research 2
... be appointed for Scotland for coordinating efforts when an epidemic ... for giving his expert advice will be paid ?50,000 annually.// ... can mutate to spread rapidly among human beings. The exact ... revealed. The person appointed will dedicate himself solely to a ...
... created a non-invasive sensor that will help treat ... a patient faces respiratory distress in the emergency ... via a mask. But for some people with ... down the body's breathing reflex. , ,Spotting ...
... the US and Canada are looking to India to ... ,"Our consortium is trying to network to provide ... Remmers, a pioneer in the study of sleep disorder ... the consortium would include Christian Guilleminault, known as the ...
... the press that the drug Dasatinib has led to reduction ... , This drug is very effective in the ... previously used drug Gleevec. ,Chronic myeloid leukemia (CML) ... stage and the blast stage.,Dasatinib was tried on all these ...
... to enroll in treatment trials for lung cancer, according to ... of CANCER, the journal of the American Cancer Society.// ... a part of the chemotherapy regimen are primarily approved after ... well as researchers have stressed the need to enroll more ...
... Robarts Research Institute have found that supplementation of GSK-3 ... produce immune cells which fights against cancer cells.// Researchers ... in the treatment of Alzheimer’s and diabetes to boost ... effects. ,Cancer chemotherapy apart from being ...
Cached Medicine News:Health News:Cheap Indian devices sought to treat sleep disorder 2Health News:Wonder drug Dasatinib gives hopes to leukemia patients 2
(Date:9/22/2014)... Children,s National Health System has announced ... 5 p.m. EDT for its "Make Your Medical ... continued strong interest from inventors.  Two ... to the winning presentations at the Sheikh Zayed Institute ... Children,s National in October. For competition details,  click ...
(Date:9/22/2014)... 2014 Decision Resources Group finds that by the ... be worth $2 billion (U.S. dollars), increasing at a compound ... years (to 2018). This growth comes as Chile ... and 4.9 percent expected over the next three to five ... but highly competitive. The pharmaceutical market is dominated by prescription ...
(Date:9/22/2014)... DIEGO , Sept. 22, 2014  Aethlon ... targeted therapeutic devices to address infectious disease, cancer ... Defense Advanced Research Projects Agency (DARPA) has informed ... option to proceed with year four of a ... Aethlon on September 30, 2011 under DARPA,s Dialysis-Like ...
Breaking Medicine Technology:Calling all medical innovators: Submit your pediatric medical device pitch for Children's National competition by Sept. 29 2Calling all medical innovators: Submit your pediatric medical device pitch for Children's National competition by Sept. 29 3Despite Its Limited Size, Chile's Pharmaceutical Market Offers Growing Opportunity for Drug Industry 2Despite Its Limited Size, Chile's Pharmaceutical Market Offers Growing Opportunity for Drug Industry 3Aethlon Medical Receives Notice of DARPA Contract Renewal 2Aethlon Medical Receives Notice of DARPA Contract Renewal 3Aethlon Medical Receives Notice of DARPA Contract Renewal 4
... of six analyzer models providing a range of ... include pH, PCO 2 , PO 2 , ... calcium, chloride, glucose, and lactate. Test results are ... saving design provides the smallest footprint of any ...
... The modular design of Sleepscan VISION ... as economical upgrade opportunities. Sleepscan VISION utilizes ... to the computer through a standard Ethernet ... in the computer, allowing the Sleepscan VISION ...
... first 192 channel simultaneous sampling EEG with ... routine EEG exam rooms as well as ... Optional analysis software for automatic spike ... sleep analysis. Quality Data Acquisition ,The ...
... purchase an XLTEK Mobee, you're getting an ambulatory ... the Mobee32 and the Mobee O2 can be ... traditional in-lab EEG monitoring, or in-lab sleep studies. ... for full 10/20 electrode placement. The Mobee O2 ...
Medicine Products: