Navigation Links
Estrogen plus progestin use linked with increased breast cancer incidence and mortality
Date:3/29/2013

Estrogen plus progestin use is linked with increased breast cancer incidence. In addition, prognosis is similar for both users and nonusers of combined hormone therapy, suggesting that mortality from breast cancer may be higher for hormone therapy users as well, according to a study published March 29 in the Journal of the National Cancer Institute.

In the Women's Health Initiative (WHI) randomized trial, estrogen plus progestin was associated with an increase in both breast cancer incidence and mortality. However, most observational studies have linked estrogen plus progestin with more positive outcomes.

In order to determine the differences between the WHI trial and other observational studies, Rowan T. Chlebowski, M.D., Ph.D., Los Angeles Biomedical Research Institute (LA BioMed) lead researcher and colleagues, looked at postmenopausal women with no prior hysterectomy with negative mammograms within two years who were either users or non-users of estrogen and progestin combined therapy.

The researchers found that breast cancer incidence was higher in estrogen plus progestin users than incidence in nonusers. Women who started hormone therapy closer to menopause had a higher breast cancer risk with a weakening influence as the time from menopause increased.

"Because survival after breast cancer diagnosis did not differ between estrogen plus progestin users and nonusers, the higher breast cancer incidence of those using estrogen plus progestin may lead to increased breast cancer mortality on a population basis," the authors write.

In an accompanying editorial, Catherine Schairer, Ph.D., and Louise A. Brinton, Ph.D., both of the National Cancer Institute, write that questions remain about whether the data analyzed from the WHI observational study resolves the differences in tumor prognosis and tumor characteristics when compared to the WHI randomized trial. They write that, "In general, tumors in estrogen plus progestin users in the WHI Observational Study were not significantly different from those in non-hormone users with regard to number of positive lymph nodes or tumor size, but were more likely to be well differentiated and positive for hormone receptors, findings which are similar to other observational studies." This, however, did not translate into a survival benefit. They recommend further analyses in this and other datasets of currency and duration of hormone use in relationship to tumor development to fully resolve the issue of tumor characteristics associated with estrogen plus progestin therapy.


'/>"/>

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Estrogen helps keep joint pain at bay after hysterectomy
2. Maturitas publishes clinical guide on low-dose vaginal estrogens for vaginal atrophy
3. Genetic markers for testosterone and estrogen level regulation identified
4. BUSM researchers identify genetic markers for testosterone, estrogen level regulation
5. Early-onset baldness in African-American men may be linked to prostate cancer
6. Cedars-Sinai study: Obesity may be linked to microorganisms living in the gut
7. Higher soy intake prior to lung cancer diagnosis linked to longer survival in women
8. Certain Lifestyle Factors Linked to Arthritis in Study Patients
9. Desire to Succeed Linked to Better Grades in College
10. Smokefree workplaces linked to smokefree homes in India
11. Energy Drinks Linked to Changes in Heart Rhythm
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... 12, 2016 , ... Young Asset Protection, a full service ... the latest charity campaign in their community enrichment program. Art Expression utilizes after-school ... cause are currently being accepted at: http://artexpressioninc.org/ . , Art Expression is ...
(Date:2/12/2016)... ... February 12, 2016 , ... J Thomas ... by continuing it’s commitment to act as Agents of Change in the community, ... with area homeless families to fulfill immediate needs and help them move into ...
(Date:2/12/2016)... Pa. (PRWEB) , ... February 12, 2016 , ... ... sort through a world of exterior design possibilities. CertainTeed, North America’s leading brand ... tools by expanding the product offerings showcased in the mobile version of the ...
(Date:2/12/2016)... ... February 12, 2016 , ... The Central Coast Autism Spectrum Center (CCASC) invites teens ages 11-18 ... night of fun for teens with and without special needs to gather in a safe ... the event. The dance will take place on Saturday, Feb. 13 from 7 to 9:30 ...
(Date:2/12/2016)... CA (PRWEB) , ... February 12, 2016 , ... ... Film Studios. The new cartoon style themes are great for showcasing pictures, videos as ... customized scene generators, titles like introductions, lower thirds, transitions and a beautiful frame overlay. ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 12, 2016  Innophos Holdings, Inc. (NASDAQ: IPHS ), ... today announced that it will host a live conference call ... discuss its fourth quarter and full year 2015 results. ... release detailing fourth quarter and full year results will be ... --> --> The conference ...
(Date:2/12/2016)... -- SI-BONE, Inc., a medical device company that pioneered the use of ... (MIS) device indicated for fusion for certain disorders of the sacroiliac ... Administrative Contractor (MAC) covering the states of Connecticut ... Massachusetts , Minnesota , ... Rhode Island , Vermont ...
(Date:2/12/2016)... 2016 On Thursday, Feb. 11, 2016, surgeons ... David,s North Austin Medical Center successfully completed the first ... ® Surgical System with Trumpf Medical,s advanced operating ... Lakshman , M.D., colorectal surgeon at the Texas Institute ... Table Motion technology, which seamlessly combines the da Vinci ...
Breaking Medicine Technology: