Navigation Links
Estrogen fuels autoimmune liver damage
Date:4/30/2013

erleukin-6 receptors were blocked or missing compared with normal female mice. On the other hand, male mice and female mice with missing ovaries had nearly undetectable levels of interleukin-6, while castrated male mice showed simultaneous upticks in both estrogen and interleukin-6.

The research team further zeroed in on a class of cells known as regulatory T cells, whose main function is keeping tabs on other immune cells to ensure they don't turn against the body's own tissues. When researchers compared the number of regulatory T cells present in the spleens of male and female mice, they noticed far fewer regulatory T cells in the spleens of female mice. The spleen, the researchers explain, is the primary residence of mature immune cells.

"Deficiency of regulatory T cells effectively takes the reins off other immune cells, leading to overactive immunity," Njoku says.

In a final, dot-connecting move, the researchers immersed spleen-derived immune cells in estrogen. What they observed proved beyond doubt that estrogen, interleukin and regulatory T cells form a powerful triangle. Estrogen induced the immune cells of female mice to express more interleukin-6, which in turn diminished the expression of inflammation-taming regulatory T cells.

When the researchers injected sick female mice with a booster dose of regulatory T cells, their liver inflammation subsided to levels seen in male mice.

This powerful response, the researchers say, suggests that therapy with regulatory T cells may reduce estrogen-related liver damage in patients with autoimmune hepatitis. Such treatment, however, remains years away from human application.

One reason, the researchers say, is that regulatory T cells maintain the fine equilibrium between overactive and underactive immunity. Because an overactive immune system can lead to autoimmune diseases and an underactive one can promote tumor growth, any therapy with regulatory T cells mus
'/>"/>

Contact: Ekaterina Peshva
epeshev1@jhmi.edu
410-502-9433
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Estrogen Level in Pregnancy May Affect Breast Cancer Risk in Daughters
2. Estrogen plus progestin use linked with increased breast cancer incidence and mortality
3. Estrogen helps keep joint pain at bay after hysterectomy
4. Maturitas publishes clinical guide on low-dose vaginal estrogens for vaginal atrophy
5. Genetic markers for testosterone and estrogen level regulation identified
6. BUSM researchers identify genetic markers for testosterone, estrogen level regulation
7. Muscular Development Store Affirms Whey Protein Fuels Strong Workouts
8. 1 week and counting: Dont cut the research that fuels the US economy
9. Evidence on abortion figures overestimated in Mexico fuels scientific debate in medical journal
10. Autoimmune disease linked to pregnancy loss, stroke more often than you’d expect
11. Statins have potential to treat an autoimmune clotting disorder called antiphospholipid syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... 1 September 2014: Permanent atrial fibrillation (AF) doubles the ... research in more than 6 000 patients presented at ... The findings suggest that a simple clinical assessment of ... estimate stroke risk. , Ischaemic stroke is the second ... a million deaths and many more disabled patients each ...
(Date:9/1/2014)... Bioinformatics refers to an interdisciplinary ... and genetic data. A major part of this ... tools to generate and process useful biological data. ... computation. While bioinformatics simply makes use of computers ... related concepts, biological computation refers to the subfield ...
(Date:9/1/2014)... September 01, 2014 Top10BestSEOHosting.com has ... many web host suppliers carefully, Top10BestSEOHosting.com is here ... the best web hosting suppliers in 2014. , ... clients with a top-of-the-line shared hosting plan. The ... easy-to-use platform that is affordable, accessible and powerful ...
(Date:9/1/2014)... Diego, CA (PRWEB) September 01, 2014 ... daily regarding all the latest information from the FDA ... , The US FDA announced on August 28, that ... recalled (Class I) as the device may ... the DePuy Synthes Craniomaxillofacial (CMF) Distraction System is an ...
(Date:9/1/2014)... 01, 2014 Psychogenic Non-epileptic Seizures (PNES), ... psychological disorder that can have devastating effects on those ... epileptic seizures however, they are not produced by electrical ... It is estimated that the numbers of persons ... multiple sclerosis. , Dr. Lorna Myers, Director ...
Breaking Medicine News(10 mins):Health News:Permanent AF doubles risk of stroke compared to paroxysmal AF 2Health News:Bioinformatics Market: A fusion of Computers and Biological Data 2Health News:Bioinformatics Market: A fusion of Computers and Biological Data 3Health News:Bioinformatics Market: A fusion of Computers and Biological Data 4Health News:Why Top10BestSEOHosting.com Calls Them Great Web Hosting Suppliers 2Health News:DePuy Synthes Craniomaxillofacial Distraction System Recalled (Class I): AttorneyOne Monitors and Keeps Consumers Informed 2Health News:DePuy Synthes Craniomaxillofacial Distraction System Recalled (Class I): AttorneyOne Monitors and Keeps Consumers Informed 3Health News:The Northeast Regional Epilepsy Group (NEREG) Offers First Conference on Psychogenic Non-epileptic Seizures (PNES) on September 20, 2014 in New Jersey 2
... Tobacco Recognized Nationally-, WASHINGTON, May 20 Michelle ... Youth Advocate of the Year,by the Campaign for Tobacco-Free ... is being honored at a gala in the nation,s,capital ... grant winner,three other regional winners and a group winner., ...
... Mich., May 19 Patrick Hendry lost,his career, home, wife ... seven years in and out of the hospital, trying every ... trying,electro-convulsive therapy, similar to shock therapy., "That was a ... and lost," said Hendry. "It,s difficult to figure out what ...
... WASHINGTON, May 20 Auriel Rolle-Polk, 17, of,Tallahassee, FL ... the,Year by the Campaign for Tobacco-Free Kids for her ... at a gala in the nation,s capital,on May 20 ... regional winners and a group winner., Auriel, a ...
... (Amex: CPD ) announced that the Company ... year 2008 ended March 31, 2008,prior to the ... Detroit-based Caraco Pharmaceutical Laboratories, Ltd., develops,manufactures, markets and ... wholesalers, distributors,drugstore chains and managed care providers., ...
... Ischemic injury to the bowel is a well known disease ... findings. A sudden drop in the colonic blood supply is ... of macrovascular mesenteric vein rarely causes ischemia of the bowel. ... by obstruction of the mesenteric and splenic veins. , ...
... This release is available in Spanish . , , A ... out a study on the psychological process that triggers the craving ... bases to determine the brain mechanisms that activate this state and ... from the Department of Personality, Evaluation and Psychological Treatment ...
Cached Medicine News:Health News:Campaign for Tobacco-Free Kids Honors Michelle Mays of Rhinelander, WI As Youth Advocate of the Year 2Health News:Man who Lost Everything Comes to Detroit to Spread Message of Hope 2Health News:Campaign for Tobacco-Free Kids Honors Auriel Rolle-Polk of Tallahassee, FL As Youth Advocate of the Year 2Health News:Caraco Pharmaceutical Laboratories, Ltd. to Announce Fourth Quarter and Fiscal Year 2008 Results on May 29, 2008 2Health News:A research on 'craving' for tobacco establishes the bases for addiction control 2
(Date:8/29/2014)... Ore. , Aug. 29, 2014 /PRNewswire-iReach/ -- ... Accessory (Axilla) Strap for the SAM Junctional Tourniquet.  ... SAM Medical Products announced today ... voluntary recall to address a potential issue with ... used for the Axilla application of the SAM ...
(Date:8/29/2014)... Calif. , Aug. 29, 2014 Thoratec ... in device-based mechanical circulatory support therapies to save, support ... participating in the 2014 Morgan Stanley Global Healthcare Conference ... Burbach , President and Chief Executive Officer, will provide ... Eastern Daylight Time (9:55 a.m., Pacific Daylight Time).   ...
(Date:8/29/2014)... 29, 2014 According to ... by Extraction type (SFE, Cold Pressed, Organic Solvent, & ... Pharmaceutical, Food Supplements, Fragrance, & Others) - Global Trends ... and segments the Amaranth Seed Oil Market with ... in terms of value. The Amaranth Seed Oil ...
Breaking Medicine Technology:SAM Medical Products Implements Voluntary Recall of its Accessory (Axilla) Strap for the SAM Junctional Tourniquet. 2Amaranth Seed Oil Market worth $700.6 Million by 2019 2Amaranth Seed Oil Market worth $700.6 Million by 2019 3Amaranth Seed Oil Market worth $700.6 Million by 2019 4
... RALEIGH, N.C., Aug. 22, 2011 BioDelivery Sciences International, ... the commercial launch and availability of ONSOLIS (fentanyl buccal ...   (Logo: http://photos.prnewswire.com/prnh/20110217/CL49801LOGO) ONSOLIS is ... it will be marketed as BREAKYL) for the management ...
... SPRING, Md., Aug. 19, 2011 The U.S. Food ... treat Hodgkin lymphoma (HL) and a rare lymphoma known ... (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO) Lymphomas are cancers of ... combines an antibody and drug, allowing the antibody to ...
Cached Medicine Technology:BioDelivery Sciences Announces Commercial Launch of ONSOLIS in Canada 2BioDelivery Sciences Announces Commercial Launch of ONSOLIS in Canada 3FDA Approves Adcetris to Treat Two Types of Lymphoma 2FDA Approves Adcetris to Treat Two Types of Lymphoma 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: