Navigation Links
Estrogen found to increase growth of the most common childhood brain tumor
Date:2/17/2009

CINCINNATIUniversity of Cincinnati (UC) researchers have discovered that estrogen receptors are present in medulloblastomathe most common type of pediatric brain tumorleading them to believe that anti-estrogen drug treatments may be beneficial in limiting tumor progression and improving patients' overall outcome.

This research is being published in the March 2009 edition of Endocrinology.

In estrogen-responsive cancerssuch as breast cancerestrogen receptors act to increase tumor growth and progression. Estrogen receptors are also the most important drug targets for the treatment of breast cancer.

"Current therapies for medulloblastoma involve cranial surgery, chemotherapy and radiation," says Scott Belcher, PhD, principal investigator of the study. "This discovery suggests that we may be able to use anti-hormone or estrogen drug therapieslike those used to treat breast cancersto limit progression of these childhood brain tumors and to decrease the adverse side-effects of radiation treatment."

Medulloblastoma, or MD, is a highly malignant brain tumor, most commonly diagnosed in children.

Patients with MD typically have a five-year survival rate between 50 and 70 percent, and survivors who endure current, more aggressive treatments face an increased risk for chronic illnesses such as diabetes or cardiovascular disease later in life.

Belcher, an associate professor in the department of pharmacology and cell biophysics at UC, and his team examined tumor tissue from 22 patients between the ages of 6 months and 18 years.

They found evidence of estrogen receptors, particularly estrogen receptor beta, in the cancerous cells of every tumor analyzed.

"MD manifests when specific neuron precursors in the brain fail to stop normally differentiating into mature neurons," Belcher says. "Our previous studies showed that estrogen receptors are regulated during differentiation of these neuronal precursors. MD growth and tumor cell formation can be blocked by inhibiting the activity of these receptors."

Belcher said these results demonstrate the importance of "bench to bedside" discoveries.

"We started in tumor cells and then moved to animal models of MD and found that we could stop the growth of tumors using anti-estrogen therapies," he says. "We've been able to identify these receptors in humans. We are now hoping that our basic developmental biology findings can take the final step by stopping the growth of these tumors in humans."

"We believe that development of rational anti-estrogen drug therapies for this highly malignant cancer is a possibility and could improve the lives of many children and adult survivors," he continues.


'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati
Source:Eurekalert

Related medicine news :

1. New link between estrogen and breast cancer
2. UCLA study identifies designer estrogen as potential MS drug
3. Cholesterol byproduct blocks heart health benefits of estrogen
4. Gene May Influence Breast Cancer-Estrogen Link
5. Duramed Launches New Indication for ENJUVIA(TM) (Synthetic Conjugated Estrogens, B) at North American Menopause Society Annual Meeting
6. Estrogen Levels in Blood Predict Breast Cancers Return
7. Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection
8. New study finds adverse effects of estrogen replacement therapy are related to the dose
9. Estrogen Supplements May Raise Odds of Benign Breast Disease
10. Estrogen therapy increases benign breast disease risk
11. Previously unseen switch regulates breast cancer response to estrogen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... ... autologous fat (adipose) transfer systems announces the issuance of United States Patent Number ... for its adipose filtration technology. The '398 and '324 patents cover methods ...
(Date:7/24/2017)... Georgia (PRWEB) , ... July 24, 2017 , ... ... comprehensive sleep management solution focused on delivering end-to-end sleep health care ... program. , Recent literature shows that adherence rates for positive airway pressure (PAP) ...
(Date:7/24/2017)... ... July 24, 2017 , ... Committed to ... have enrolled over 100,000 children in their treatment program. Clubfoot is a pervasive ... areas where treatment is limited or non-existent. Without intervention, these children are destined ...
(Date:7/24/2017)... Shandong Province (PRWEB) , ... July 24, 2017 ... ... Chinese Medicine's "Chinese Medicine Clinical Vitiligo Hospital" was set up, and the awarding ... Administration of traditional Chinese medicine, the head of the army's health system, and ...
(Date:7/24/2017)... ... 24, 2017 , ... “A Short Walk to the Mailbox”: a remarkable memoir ... of published author, Ed Clark. Ed Clark is a church music director and ... a minister of music and worship leader for over fifty years. He has ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)...  The tenth annual BioPharm America™ will ... at the Sheraton Boston Hotel, September 26–27. The event ... decision makers and innovative biotech startup companies. The event ... two impactful days. BioPharm America is now part of ... opportunities with 4,500+ life science industry influencers participating in ...
(Date:7/5/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ... company focused on the development of oral drug delivery systems, ... Securities Authority to dual-list its common stock on the Tel ... on the TASE on July 12, 2017 under the ticker ... it is expected that Oramed will be included in the ...
(Date:6/30/2017)... ROCKVILLE, Md. , June 30, 2017 ... that since the start of May, at least ten ... financings include private investments, public offerings and a loan ... $3.3 million to almost $80 million.  Kalorama Information provides ... customers of its Diagnostics Knowledge Center. ...
Breaking Medicine Technology: