Navigation Links
Estrogen Supplements May Raise Odds of Benign Breast Disease
Date:4/8/2008

Women on the hormone more than doubled the risk for this precancerous condition

TUESDAY, April 8 (HealthDay News) -- Women who took a common form of estrogen as hormone replacement therapy during menopause more than doubled their risk for certain types of benign breast disease compared with women who took a placebo, researchers say.

One such condition -- benign proliferative breast disease -- is relatively common and has been linked with an increased risk of breast cancer.

The clinical implication for women contemplating the use of supplemental estrogen "doesn't really change," said study author Dr. Tom Rohan, chairman of the department of epidemiology and population health at the Albert Einstein College of Medicine in New York City.

"It's the idea that women need to balance the benefits and risks," he said. This new finding does point to an added risk, however, Rohan added.

His team published the study online April 8 in the Journal of the National Cancer Institute.

Until now, there have been no randomized studies on the effect of conjugated equine estrogen (CEE), a type of hormone replacement therapy (HRT), on the risk of developing benign proliferative breast disease. Randomized trials are considered the gold standard of science.

The current data comes from the Women's Health Initiative CEE trial, in which almost 11,000 postmenopausal women were randomly assigned to receive CEE or a placebo.

Women taking CEE had more than double the risk of developing benign proliferative breast disease over an average follow-up of almost seven years, the team found.

It is thought that invasive breast cancer can result from a succession of conditions, with benign proliferative breast disease without atypia (cell abnormalities) sometimes being followed by proliferative disease with atypia before the development of in situ (localized) cancer.

This study did not see an actual increase in the risk of developing invasive breast cancer but the progression from benign proliferative breast disease to invasive breast cancer could take a decade, in which case this study was not long enough to note that change.

The progress of the women in the trial is still being followed, the researchers noted.

The Womens Health Initiative has also found that women taking estrogen plus another hormone, progestin, had an increased risk both of breast cancer and of benign proliferative breast disease after only about five years of follow-up. This may suggest that progestin plays a role in breast cancer development, the authors stated.

"This makes perfect sense," said Dr. Jay Brooks, chairman of hematology/oncology at Ochsner Health System in Baton Rouge, La. "Estrogen does stimulate breast tissue activity and my concern is that, if you do move along a continuum as the hypothesis states, as you stimulate the breast are you going to be able to predict which women are going to develop into something worse and women who are going to stay in a benign state. I can't predict which of those women will develop [breast cancer] down the line but we know that this agent is highly stimulatory to breast tissue so the question is, do you want to be taking an agent that stimulates breast tissue?"

More information

The U.S. National Heart, Lung, and Blood Institute has more on the Women's Health Initiative.



SOURCES: Tom Rohan, M.D., Ph.D., chairman, department of epidemiology and population health, Albert Einstein College of Medicine, New York City; Jay Brooks, M.D., chairman, hematology/oncology, Ochsner Health System, Baton Rouge, La.; April 8, 2008, Journal of the National Cancer Institute online


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New link between estrogen and breast cancer
2. UCLA study identifies designer estrogen as potential MS drug
3. Cholesterol byproduct blocks heart health benefits of estrogen
4. Gene May Influence Breast Cancer-Estrogen Link
5. Duramed Launches New Indication for ENJUVIA(TM) (Synthetic Conjugated Estrogens, B) at North American Menopause Society Annual Meeting
6. Estrogen Levels in Blood Predict Breast Cancers Return
7. Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection
8. New study finds adverse effects of estrogen replacement therapy are related to the dose
9. Antioxidant Supplements May Raise Womens Skin Cancer Risk
10. Vitamin D Supplements May Lengthen Life
11. Wellcorps International Unveils New Nutritional Supplements
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Estrogen Supplements May Raise Odds of Benign Breast Disease
(Date:5/26/2016)... ... ... Despite last week’s media reports hinting at a June rate hike after the Federal ... an interest rate increase, according to Rajeev Dhawan of the Economic Forecasting Center at ... Committee (FOMC) dot charts are of interest to the press for their noise potential,” ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cabot Corporation, Pfizer, and 3M ... to court documents and SEC filings. A jury has returned a verdict ... Optical Corporation, Case No. BC588866, Los Angeles County, California. The jury awarded $22.8 ...
(Date:5/26/2016)... ... May 26, 2016 , ... Connor Sports, through its Connor Cares ... the Tamika Catchings Legacy Tour that will commemorate the Indiana Fever legend’s ... surfaces in all forms and levels of the game, Connor Sports has committed to ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cardiac arrhythmia is ... impact on long-term patient survival, reports a team of UPMC researchers in the ... in the Journal of Thoracic and Cardiovascular Surgery, provide critical information that will ...
(Date:5/26/2016)... ... May 26, 2016 , ... Catalent ... for drugs, biologics, consumer health and global clinical supply services, today announced two ... support the company’s continued investment and strategic growth plans in the Asia Pacific ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 25, 2016 Inivata, a ... of circulating tumour DNA (ctDNA) analysis to improve ... of Professor Clive Morris as Chief ... the clinical development programme, scientific collaborations, and through ... significant improvements in clinical outcomes for patients. ...
(Date:5/24/2016)... May 24, 2016   , ... non-inferiority in overall bowel cleansing and superiority in ... leansing of the ... ) , Norgine B.V. today announced new positive data ... and ascorbate bowel preparation) versus standard 2 litre PEG with ascorbate. ...
(Date:5/24/2016)... INDIANAPOLIS , May 24, 2016  Joe Marziani has joined VMS BioMarketing as ... chief executive officer, today. In his new role, Marziani will lead the company,s business ... care professionals to improve outcomes. Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
Breaking Medicine Technology: