Estrogen Plays Surprise Role in Breast Cancer...(men experience wild changes in estrogen ...),Health

Date:8/18/2009

men experience wild changes in estrogen levels, depending on whether they're menstruating, pregnant or postmenopausal," Ellis explained. "All this is regulated in an exquisite way, which we actually understand fairly well. These results mean the feedback loops may be corrupted in some ways."

Brooks agreed that it's "counterintuitive."

"The estrogen receptor on a cancer cell is not a simple thing," he said. "Aromatase inhibitors may somehow allow the cells to reactivate certain [hormone] receptors [on the tumor] that may actually be different than they were to start with."

The researchers said they were planning further studies to see which group of women might benefit most from the protocol.

More information

The National Cancer Institute has more on treating breast cancer.

SOURCES: Matthew J. Ellis, M.B., BChir., Ph.D., professor, medicine, Washington University School of Medicine, and oncologist, Siteman Cancer Center, St. Louis; Ramona Swaby, M.D., assistant professor, medical oncology, Fox Chase Cancer Center, Philadelphia; Jay Brooks, chairman, hematology/oncology, Ochsner Health System, Baton Rouge, La.; Aug. 19, 2009, Journal of the American Medical Association

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