Navigation Links
Estrogen May Play Role in Rising Rates of Head, Neck Cancer
Date:1/4/2011

TUESDAY, Jan. 4 (HealthDay News) -- Rates of head and neck cancer are rising among some groups of people, including young women without any known risk factors. Now, a study suggests that estrogen may help the cancer spread by boosting the movement of precancerous cells in the mouth.

Previous research found that the body changes how it handles estrogen after the lungs are exposed to smoke. This may lead to lung cancer.

In the new study, researchers examined how estrogen affects cells that are cancerous or primed to become cancerous. They found that an enzyme called CYP1B1 is linked to reproduction in precancerous cells.

"In the future, we would like to find a natural or dietary agent to deplete the CYP1B1 enzyme and see if we can prevent oral cancer at the precancerous stage," Ekaterina Shatalova, a postdoctoral fellow at Fox Chase Cancer Center in Philadelphia, said in a news release from the American Association for Cancer Research.

"Our previous studies showed that the CYP1B1 enzyme sits at the hub of changes that occur in the lungs after smoke exposure. We were now able to look at its role in a more direct fashion by removing it from precancerous cells of the oral cavity," Margie Clapper, co-leader of the Cancer Prevention and Control Program at Fox Chase Cancer Center, explained in the news release.

"We found that cells lacking it move slower," Clapper added. "CYP1B1 could be a wonderful target in precancerous lesions of the head and neck because, by attacking it, we might stop these lesions from progressing or moving to a more advanced stage."

The findings could help researchers "understand factors that cause head and neck cancer, in addition to the traditional risk factors of tobacco and alcohol exposure," according to Dr. Jennifer R. Grandis, director of the Head and Neck Cancer Program at the University of Pittsburgh School of Medicine.

But the findings won't be confirmed until researchers do more work in people, the study authors noted.

The study is published in the January issue of Cancer Prevention Research.

More information

For more on head and neck cancer, visit the U.S. National Cancer Institute.

-- Randy Dotinga

SOURCE: American Association for Cancer Research, news release, Jan. 4, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Estrogen-Only Hormone Therapy May Reduce Breast Cancer Risk for Some
2. Estrogen replacement therapy speeds ovarian cancer growth, new study reports
3. Tendon Injuries May Be Linked to Estrogen Levels in Female Athletes
4. Team to study health effects of botanical estrogens
5. Estrogen not associated with lung cancer incidence and mortality among postmenopausal women
6. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
7. Scientists find link between estrogen metabolism pathway and breast cancer risk
8. Researchers find key to getting estrogens benefits without cancer risk
9. Progesterone is effective for hot flash treatment and provides an alternative to estrogen
10. Estrogen-lowering drugs minimize surgery in breast cancer patients
11. Estrogen receptor status of HER2+ breast cancer correlates with response to anti-HER therapies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Estrogen May Play Role in Rising Rates of Head, Neck Cancer
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, and ... in the eye of the beholder, according to experts who offered insights and commentary ... of Managed Care. For the full issue, click here . , For the ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published ... unfamiliar with. The article goes on to state that individuals are now more comfortable ... less common operations such as calf and cheek reduction. The Los Angeles area medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: