Navigation Links
Estrogen May Help Men's Hearts
Date:5/12/2009

Too much or too little of the hormone, though, can be damaging, study finds,,,,

TUESDAY, May 12 (HealthDay News) -- Estrogen has long been implicated as being heart protective in premenopausal women, and a new study suggests that having just the right amount of estrogen might be helpful for men as well.

The study, in the May 13 issue of the Journal of the American Medical Association, found that men with heart failure who had the lowest levels of estrogen had about four times the risk of dying as men with average levels and that men with the highest levels of estrogen had more than twice the risk of dying as men with average levels of the hormone.

"Among men with chronic heart failure and reduced left-ventricular ejection fraction, high and low concentrations of estradiol [estrogen] compared with the middle quintile of estradiol are related to an increased mortality," the researchers wrote.

However, Dr. Stephen Siegel, a cardiologist at the New York University Langone Medical Center, said that though the study "raises certain issues on how hormones may be affected or may affect cardiac function and mortality, it doesn't necessarily link cause and effect."

Heart failure occurs when the heart muscle weakens and can't pump blood as efficiently to the rest of the body as it should. As many as 5 million people in the United States currently have heart failure, according to the U.S. National Heart, Lung, and Blood Institute. Each year, about 300,000 Americans die as a result of heart failure, the institute reports.

The study, which was done in Poland, included 501 men with an average age of 58 years. All of the men had heart failure and a left ventricular ejection fraction of 28 percent. Ejection fraction is a measure of how well the heart is pumping, and the left ventricle is the heart's main pumping chamber. A normal left ventricular ejection fraction would be between 55 percent and 70 percent, according to the American Heart Association.

During the three-year follow-up period, 171 of the men died. When the researchers separated the men into groups based on their estrogen levels, they found that those with the lowest and highest levels of estrogen were more likely to have died.

The group with the lowest estrogen levels had a 44.6 percent survival rate, and those with the second-lowest scores had a 65.8 percent survival rate. The middle group had the highest survival rate, at 82.4 percent. The fourth group, which had elevated estrogen levels, had a 79 percent survival rate, and the group with the highest estrogen levels had a 63.6 percent survival rate.

"This is an interesting observation," said Dr. David Haines, chairman of cardiovascular medicine at Beaumont Hospital in Royal Oak, Mich. "But, it seems just as likely that it could be an epidemiological phenomenon."

Haines said that, based on the data from the study, he would not recommend supplementing heart failure patients with low estrogen, nor would he use medication to block the effects of estrogen on men with high levels.

"For something to be deadly at both ends is unlikely," said Dr. Stuart Katz, director of the heart failure program at the New York University Langone Medical Center in New York City. "Whenever you see this type of U-shaped relationship, it means there has to be two different explanations for what you've seen."

He said it's possible that estrogen may be a marker for worsening heart disease, but said it's probably not a more useful marker than those currently used. "I doubt this study will change what clinicians do," said Katz.

The three heart specialists agreed that though the study's observations raise interesting questions, much more research needs to be done before any changes in clinical practice might occur.

More information

Learn more about heart failure at HeartFailure.org.



SOURCES: Stephen Siegel, M.D., cardiologist, New York University Langone Medical Center, and clinical assistant professor, New York University School of Medicine, New York City; David Haines, M.D., chairman, Department of Cardiovascular Medicine, Beaumont Hospital, Royal Oak, Mich.; Stuart Katz, M.D., professor, medicine, Division of Cardiology, New York University School of Medicine, and director, Heart Failure Program, New York University Langone Medical Center, New York City; May 13, 2009, Journal of the American Medical Association


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New link between estrogen and breast cancer
2. UCLA study identifies designer estrogen as potential MS drug
3. Cholesterol byproduct blocks heart health benefits of estrogen
4. Gene May Influence Breast Cancer-Estrogen Link
5. Duramed Launches New Indication for ENJUVIA(TM) (Synthetic Conjugated Estrogens, B) at North American Menopause Society Annual Meeting
6. Estrogen Levels in Blood Predict Breast Cancers Return
7. Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection
8. New study finds adverse effects of estrogen replacement therapy are related to the dose
9. Estrogen Supplements May Raise Odds of Benign Breast Disease
10. Estrogen therapy increases benign breast disease risk
11. Previously unseen switch regulates breast cancer response to estrogen
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Estrogen May Help Men's Hearts
(Date:6/26/2016)... ... 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic ... World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. ... some of the world’s leading providers of cereal and other breakfast foods. Its residents ...
(Date:6/26/2016)... Cary, North Carolina (PRWEB) , ... June 26, 2016 , ... ... the release of a new product that was developed to enhance the health of ... harvested for centuries. , The two main herbs in the PawPaws Cat Kidney ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, ... Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. ... skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was ...
(Date:6/25/2016)... ... 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can ... CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn ... X . Simply select a ProHand generator and drag it above media or text ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
Breaking Medicine Technology: