Navigation Links
Estrogen May Have Preventive Role in Women's Schizophrenia

Symptoms, including delusions, hallucinatory behavior, improved with estradiol, study says

MONDAY, Aug. 4 (HealthDay News) -- The estrogen estradiol, when combined with antipsychotic drugs, may help relieve psychotic symptoms in women with schizophrenia, an Australian study suggests.

It included 102 women of child-bearing age with schizophrenia. For 28 days, 56 of the women received 100 micrograms of estradiol daily via a skin patch, while the other 46 received a placebo via a skin patch.

The women's psychotic symptoms, including delusions and hallucinatory behavior, were assessed weekly, and those taking estradiol showed a greater improvement in symptoms.

The study was published in the August issue of the Archives of General Psychiatry.

Estrogen's neuroprotective and psychoprotective actions may be mediated by a variety of routes, ranging from rapid actions, including antioxidant effects and enhancement of cerebral blood flow and cerebral glucose utilization, to slower, genomic mechanisms, which may include permanent modification of neural circuits, the study authors wrote.

The lack of effect for negative symptoms is consistent with literature reporting that negative symptoms are less responsive to treatment than other symptoms of schizophrenia. It is possible that longer-term treatment is required for negative symptoms to respond to treatment. Alternatively, brain regions implicated in negative symptoms may be less responsive to gonadal hormone effects.

The study authors said estrogen may have a preventive role in women with schizophrenia who have childbirth- or menopause-related hormonal changes known to cause a deterioration of their condition.

"Estrogen treatment is a promising new area for future treatment of schizophrenia and potentially for other severe mental illnesses," they concluded.

More information

Mental Health America has more about schizophrenia.

-- Robert Preidt

SOURCE: JAMA/Archives journals, news release, Aug. 4, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Team discovers new inhibitors of estrogen-dependent breast cancer cells
2. Estrogen therapy helps or hurts the brain depending on reproductive status
3. Anti-estrogen drug therapy reduces risk of invasive breast cancer in older women
4. Previously unseen switch regulates breast cancer response to estrogen
5. Estrogen therapy increases benign breast disease risk
6. Estrogen Supplements May Raise Odds of Benign Breast Disease
7. New study finds adverse effects of estrogen replacement therapy are related to the dose
8. Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection
9. Estrogen Levels in Blood Predict Breast Cancers Return
10. Duramed Launches New Indication for ENJUVIA(TM) (Synthetic Conjugated Estrogens, B) at North American Menopause Society Annual Meeting
11. Gene May Influence Breast Cancer-Estrogen Link
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article ... American Dental Association meeting in Washington D.C. revolved around the fact that proper dental ... health. The talk stressed the link between periodontal disease (more commonly referred to as ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... safe and convenient way to dispense prescription medications at home, so he invented ... way to monitor and dispense prescription medications. In doing so, it could help ...
(Date:11/27/2015)... ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the world, revealed ... 1-1 ). More than 3.7 billion people under the age of 50 – or ... to WHO's first global estimates of HSV-1 infection . , "The data shocks us ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... innovative online platform for mental health and wellness consultation, has collaborated with a ... will bridge the knowledge gap experienced by parents and bring advice from parenting ...
(Date:11/27/2015)... ... 2015 , ... Indosoft Inc., developer and distributor of the ... LTS (Long Term Support) into its Q-Suite 5.10 product line. , Making the ... a version of Asterisk that will receive not only security fixes, but feature ...
Breaking Medicine News(10 mins):
(Date:11/29/2015)... 2015  The GE Health Cloud 1 was unveiled ... North America (RSNA) meeting in ... the new cloud ecosystem and its applications will connect radiologists ... and multidisciplinary teams – both inside and outside the hospital ... of GE. "As the digital industrial leader, we are betting ...
(Date:11/29/2015)... 29, 2015   National Decision Support Company (NDSC) ... base, including notable statewide implementations. As a result, ... ACR Select, more than 1 million times per ... ACR Select provides real-time feedback on the most ... has been implemented at over 100 healthcare systems ...
(Date:11/27/2015)... 27, 2015 --> ... go online. The potential to save costs, improve treatment ... far from fully exploited as yet. Here, particular emphasis ... either via mobile tablet or directly at the patients, ... ) -->      (Photo: ...
Breaking Medicine Technology: