Navigation Links
Estrogen May Explain Why Women With Cystic Fibrosis Suffer More
Date:11/20/2008

chloride channel is wide open, allowing chloride to enter the lungs. Not so in cystic fibrosis patients. Due to a lack of hydration, mucous gets thicker and doesn't move, essentially trapping bacteria, allowing it to linger and fester illness.

Luckily, there is a second, "rescue" chloride channel that can take up some of the slack for cystic fibrosis patients.

"When people get cystic fibrosis, they don't just die after birth. The rescue channel keeps them limping on and provides enough hydration," Tarran explained. "The hypothesis is that that's OK until there's a catastrophic event like a viral infection."

Tarran and his colleagues hypothesized that estrogen might affect chloride secretion, thus explaining more severe illness in women. They measured the ability of chloride to move in and out of cells in women with cystic fibrosis who were not taking any birth control or other hormonal treatments.

While estrogen was low, there was no effect on the nasal passages. But high levels of estrogen while a woman was ovulating inhibited the rescue channel by about 50 percent.

"For a normal woman, it's no big deal because the other, huge channel is doing its job," Tarran said. "But in cystic fibrosis it is a big deal. The airway is cut by half, so maybe for four to five days each month there is a reduced ability to hydrate the airways. For a few days every month, it becomes a statistical lottery, if you happen to breathe in something nasty on those days."

Tarran's group next plans to test lung function in healthy women taking tamoxifen, the breast cancer drug that interferes with the activity of estrogen.

Dr. John Saito is assistant professor of pediatrics at Texas A&M Health Science Center College of Medicine, and director of the Cystic Fibrosis Center at Scott & White Hospital. "Everyone has suspected differences but nailing this down is difficult to do. This [new research] offers some insight as
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Estrogen and progesterone receptor isoforms expression in the stomach of Mongolian gerbils
2. Estrogen flooding our rivers, Université de Montréal study
3. Estrogen Cream No Match for Sun-Damaged Skin
4. Estrogen May Have Preventive Role in Womens Schizophrenia
5. Team discovers new inhibitors of estrogen-dependent breast cancer cells
6. Estrogen therapy helps or hurts the brain depending on reproductive status
7. Anti-estrogen drug therapy reduces risk of invasive breast cancer in older women
8. Previously unseen switch regulates breast cancer response to estrogen
9. Estrogen therapy increases benign breast disease risk
10. Estrogen Supplements May Raise Odds of Benign Breast Disease
11. New study finds adverse effects of estrogen replacement therapy are related to the dose
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Estrogen May Explain Why Women With Cystic Fibrosis Suffer More
(Date:4/18/2014)... 18, 2014) Benaroya Research Institute at Virginia Mason ... a particular molecule in metastatic breast cancer reduces both ... lung metastases. BRI scientists have found in models of ... by 60 - 80 percent and can keep the ... $1.8 million five-year grant comes from the National Cancer ...
(Date:4/18/2014)... ― A new study in the American Journal ... Google searches reveals a recurring pattern that could be ... Investigators from San Diego State University, the Santa Fe ... "healthy" Google searches (searches that included the term healthy ... the U.S. from 2005 to 2012. They found that ...
(Date:4/18/2014)... A discovery by Northwestern Medicine scientists could lead to ... scarring in people with scleroderma. , Fibrosis, or ... tightening of the skin and lungs can lead to ... The concept for new therapeutic options centers on findings ... Medicine-Rheumatology, who identified the role that a specific protein ...
(Date:4/17/2014)... who show signs of chronic inflammation in non-cancerous prostate ... having prostate cancer than those with no inflammation, according ... from the Johns Hopkins Kimmel Cancer Center. , The ... for men with so-called high-grade prostate cancer those ... indicating the presence of the most aggressive and rapidly ...
(Date:4/17/2014)... Scientists have identified new pain relief targets that ... pain. BBSRC-funded researchers at King,s College London made ... nerves in the periphery of the body. , ... and identifying mechanisms underlying pain generation and our ... related side effects." , One potential side effect ...
Breaking Medicine News(10 mins):Health News:Benaroya Research Institute evaluates immunology approach to blocking breast cancer 2Health News:New research shows people are thinking about their health early in the week 2Health News:New clues on tissue scarring in scleroderma 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:New pain relief targets discovered 2
... exposure can produce more than some tanners may bargain ... to treat skin eruptions, according to research conducted by ... "There are many reasons to be cautious ... beds to ,self-treat, skin eruptions," said Jeffrey B. Travers, ...
... small subset of normal white blood cells in the body ... The study, led by investigators at The Ohio State ... and Richard J. Solove Research Institute (OSUCCC James), shows ... subset of white blood cells called NKT cells. NKT cells ...
... , CHAMPAIGN, lll. A review of more than 160 ... compelling evidence" that all else being equal happy ... their unhappy peers. The study, in the journal ... review so far of the evidence linking happiness to health ...
... (HealthDay News) -- The use of virtual colonoscopies at U.S. ... not covered by Medicare, a new study finds. Also ... uses virtual reality technology to provide doctors with a 3-D ... entire colon and rectum. CTC is an alternative to colonoscopy ...
... WIREs Nanomedicine and Nanobiotechnology explores how nanotechnology ... marked impact on the therapeutic and diagnostic measures available ... a meterto achieve tasks that would be difficult at ... and can enter cells, making them useful for drug ...
... been on the rise in the United States. In fact, ... vehicle crash fatalities to become the leading cause of injury ... reported, they are only the tip of the iceberg. ... Research and Policy of The Research Institute at Nationwide Children,s ...
Cached Medicine News:Health News:Tanning bed exposure can be deadly when complicated by medication reactions 2Health News:A small subset of normal white blood cells gives rise to a rare leukemia, study shows 2Health News:Study: Happiness improves health and lengthens life 2Health News:Surgeons predict the future of nanomedicine in practice 2Health News:New study: Medical and financial impact of drug-related poisonings treated in US EDs 2
(Date:1/15/2014)... wearable injector slightly larger than an Oreo cookie may soon ... drugs in the large doses required to treat a wide ... genetic disorders.  An emerging biologic drugs market ... analysts.   Many of these drugs will require a new type ...
(Date:1/14/2014)... 2014 Dynamic Healthcare Services, Inc. ("DHS"), a portfolio company ... Progressive Home Medical Equipment, Inc. ("Progressive") of Clarion, ... the acquisition were not disclosed. Progressive is ... wide range of sleep, mobility, and respiratory products to customers ...
(Date:1/14/2014)...   Oligomerix, Inc. , a privately held company pioneering ... (AD) and related neurodegenerative disorders, announced today the relocation ... as of January 15, 2014 and expanded ... Medical College. Oligomerix, which is focused on ...
Breaking Medicine Technology:Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2
... Inc. today announced that the U.S. Food and Drug ... (estradiol valerate and estradiol valerate/dienogest) tablets for the treatment ... by any diagnosed conditions of the uterus (womb), in ... With this approval, Natazia is the first and only ...
... March 14, 2012  Nile Therapeutics, Inc. (OTCQB: NLTX), ... heart failure patients, today announced the schedule of ... American College of Cardiology (ACC) 61th Scientific Session, ... Monday, March 26, 2012 Time: 10:00 AM -12:00 PM ...
Cached Medicine Technology:U.S. FDA Approves First and Only Oral Contraceptive Demonstrated to Treat Heavy Menstrual Bleeding (HMB) 2U.S. FDA Approves First and Only Oral Contraceptive Demonstrated to Treat Heavy Menstrual Bleeding (HMB) 3U.S. FDA Approves First and Only Oral Contraceptive Demonstrated to Treat Heavy Menstrual Bleeding (HMB) 4Nile Therapeutics Announces Upcoming Data Presentation at the American College of Cardiology Annual Scientific Meeting 2