Navigation Links
Estrogen Level in Pregnancy May Affect Breast Cancer Risk in Daughters
Date:4/9/2013

TUESDAY, April 9 (HealthDay News) -- Daughters born to women who had excess levels of estrogen during pregnancy may be at increased risk for breast cancer, a new study suggests.

That's because high estrogen levels in the womb can disable the powerful breast cancer tumor suppressor gene BRCA1 in daughters, the researchers at Georgetown Lombardi Comprehensive Cancer Center said in a Georgetown news release.

Their study of 1-year-old girls whose mothers had high estrogen levels during pregnancy also found that the daughters had other gene abnormalities that can contribute to the risk of breast cancer and breast cancer recurrence.

This includes a gene defect in the so-called unfolded protein response pathway, which has been linked to breast cancer risk and resistance to the breast cancer drug tamoxifen.

Although the study found an association between high estrogen levels in pregnancy and factors that raise breast cancer risk in daughters, it did not prove cause and effect.

If the findings are confirmed, they could be used to identify women at increased risk for breast cancer and to lower their risk before the disease develops, the researchers said.

There are drugs available that may make it "possible to reverse the increase in breast cancer risk and prevent development of resistance to tamoxifen in these women," study lead author Leena Hilakivi-Clarke, a professor of oncology at Georgetown Lombardi, said in the news release.

The study was to be presented Tuesday at the American Association for Cancer Research annual meeting, in Washington, D.C. The data and conclusions of research presented at meetings are typically considered preliminary until published in a peer-reviewed medical journal.

More information

Breastcancer.org has more about breast cancer risk.

-- Robert Preidt

SOURCE: Georgetown University Medical Center, news release, April 9, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. BUSM researchers identify genetic markers for testosterone, estrogen level regulation
2. Genetic markers for testosterone and estrogen level regulation identified
3. Maturitas publishes clinical guide on low-dose vaginal estrogens for vaginal atrophy
4. Estrogen helps keep joint pain at bay after hysterectomy
5. Estrogen plus progestin use linked with increased breast cancer incidence and mortality
6. Normal triglyceride levels in people of African descent may hinder diagnosis of metabolic syndrome
7. Heart failure patients with diabetes may benefit from higher glucose levels
8. Cholesterol Levels Vary Widely by Country: Study
9. Researchers determine vitamin D blood level for reducing major medical risks in older adults
10. Simple assault and ground level fall do not require cervical spine CT
11. Low oxygen levels could drive cancer growth
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Estrogen Level in Pregnancy May Affect Breast Cancer Risk in Daughters
(Date:6/27/2016)... , ... June 27, 2016 ... ... the patient payment industry today announced its strategic partnership with Connance, a ... workflows. , The two companies’ proven, proprietary technology combine to provide health ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... On June ... sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, ... of the city’s history as home to some of the world’s leading providers of ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women ... diagnosed with endometriosis. These women need a treatment plan to not only alleviate ... that can help for preservation of fertility and ultimately achieving a pregnancy. The ...
(Date:6/25/2016)... California (PRWEB) , ... June 25, 2016 , ... "With ... fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... customizable and all within Final Cut Pro X . Simply select a ProHand ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Dublin ... addition of the " Global Markets for Spectroscopy ... This report focuses on the ... review, including its applications in various applications. The report ... includes three main industries: pharmaceutical and biotechnology, food and ...
(Date:6/24/2016)... 2016 The Academy of Managed Care Pharmacy ... that would allow biopharmaceutical companies to more easily share ... formulary and coverage decisions, a move that addresses the ... The recommendations address restrictions in the sharing ... drug label, a prohibition that hinders decision makers from ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American ... function testing company, is now able to perform sophisticated lung assessments ... ndd Medical Technologies , Inc. Patients are no ...  Thanks to ndd,s EasyOne PRO ® , ARL patients like Jeanne ... needed testing done in the comfort of her own home. ...
Breaking Medicine Technology: