Navigation Links
Estrogen Level in Pregnancy May Affect Breast Cancer Risk in Daughters
Date:4/9/2013

TUESDAY, April 9 (HealthDay News) -- Daughters born to women who had excess levels of estrogen during pregnancy may be at increased risk for breast cancer, a new study suggests.

That's because high estrogen levels in the womb can disable the powerful breast cancer tumor suppressor gene BRCA1 in daughters, the researchers at Georgetown Lombardi Comprehensive Cancer Center said in a Georgetown news release.

Their study of 1-year-old girls whose mothers had high estrogen levels during pregnancy also found that the daughters had other gene abnormalities that can contribute to the risk of breast cancer and breast cancer recurrence.

This includes a gene defect in the so-called unfolded protein response pathway, which has been linked to breast cancer risk and resistance to the breast cancer drug tamoxifen.

Although the study found an association between high estrogen levels in pregnancy and factors that raise breast cancer risk in daughters, it did not prove cause and effect.

If the findings are confirmed, they could be used to identify women at increased risk for breast cancer and to lower their risk before the disease develops, the researchers said.

There are drugs available that may make it "possible to reverse the increase in breast cancer risk and prevent development of resistance to tamoxifen in these women," study lead author Leena Hilakivi-Clarke, a professor of oncology at Georgetown Lombardi, said in the news release.

The study was to be presented Tuesday at the American Association for Cancer Research annual meeting, in Washington, D.C. The data and conclusions of research presented at meetings are typically considered preliminary until published in a peer-reviewed medical journal.

More information

Breastcancer.org has more about breast cancer risk.

-- Robert Preidt

SOURCE: Georgetown University Medical Center, news release, April 9, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. BUSM researchers identify genetic markers for testosterone, estrogen level regulation
2. Genetic markers for testosterone and estrogen level regulation identified
3. Maturitas publishes clinical guide on low-dose vaginal estrogens for vaginal atrophy
4. Estrogen helps keep joint pain at bay after hysterectomy
5. Estrogen plus progestin use linked with increased breast cancer incidence and mortality
6. Normal triglyceride levels in people of African descent may hinder diagnosis of metabolic syndrome
7. Heart failure patients with diabetes may benefit from higher glucose levels
8. Cholesterol Levels Vary Widely by Country: Study
9. Researchers determine vitamin D blood level for reducing major medical risks in older adults
10. Simple assault and ground level fall do not require cervical spine CT
11. Low oxygen levels could drive cancer growth
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Estrogen Level in Pregnancy May Affect Breast Cancer Risk in Daughters
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the ... save lost souls in the Philippines. “The Journey: From the Mountains to the Mission ... of the Bible. She has taught all ages and currently teaches a class of ...
(Date:10/12/2017)... Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... centers in the U.S., announced today its plans to open a flagship location in ... will occupy the former Rooms To Go store next to Office Depot in the ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
(Date:10/12/2017)... ... , ... Leading pediatric oncology experts at Children’s National Health System ... of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the ...
(Date:10/12/2017)... ... October 12, 2017 , ... In ... taxes a year. In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, ... overseas retirement havens have extremely low property-tax rates, which contributes to the relatively ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017  AllianceRx Walgreens Prime, the combined central specialty ... pharmacy benefit manager Prime Therapeutics LLC (Prime), today officially ... the unveiling of new signage at its headquarters in ... at a few other company-owned facilities across the country. ... some of whom will begin to see the AllianceRx ...
(Date:9/28/2017)... 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will ... and webcast on Friday, November 3, 2017, beginning at ... at approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... financial performance and guidance for 2018, Hill-Rom executives will ... operational performance, and long-range financial outlook through 2020. ...
(Date:9/27/2017)... , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading ... announced that its MyDario product is expected to appear on The Dr. ... The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show ... The segment ...
Breaking Medicine Technology: