Navigation Links
Erythropoietin and the regulation of cancer stem cell growth and survival
Date:1/6/2014

In recent years, non-hematopoietic effects of erythropoietin (EPO), via its binding to the EPO receptor in non-hematopoietic tissues, including cancerous tissues, has been reported by many different laboratories worldwide. However, it remains controversial concerning whether EPO, particularly recombinant EPO that is used to treat anemia in patients, may promote cancer cell proliferation and survival.

In this paper, the authors show evidence indicating the presence of autocrine/paracrine EPO in the conditioned medium of cultured breast cancer cells and a functional role of an EPO-EPOR autocrine/paracrine loop in regulating tumor cell invasion and migration, and the stem-ness of breast cancer cells. The data support a novel paradigm wherein autocrine/paracrine EPO may regulate tumorigenesis of breast cancer via stimulating a small percentage of stem-like cancer cells or tumor-initiating cells. This mode of EPO action may explain why some studies reported in literature failed to demonstrate a pro-proliferative and pro-survival role of EPO in cancer cells when whole-populations of cancer cells were analyzed in these studies.

For the full report by Liang et al. in Cancer Biology & Therapy, visit the following link: https://www.landesbioscience.com/journals/cbt/article/26717/


'/>"/>

Contact: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience
Source:Eurekalert

Page: 1

Related medicine news :

1. Regulation by proteins outside cancer cells points to potential new drug target
2. BUSM researchers identify genetic markers for testosterone, estrogen level regulation
3. Genetic markers for testosterone and estrogen level regulation identified
4. ESC says 50 percent of CVD deaths in Europe could be avoided with proper regulation
5. Aurka-to-p53 signaling: A link between stem cell regulation and cancer
6. Trudeau researchers identify unforeseen regulation of the anti-bacterial immune response
7. Protein regulation linked to intellectual disability
8. BMJ and Daily Telegraphs fake hip exposes failing European device regulation
9. Dec. 12 Atlantic Information Services Webinar to Address the Nuances of New HHS Essential Health Benefits Regulations
10. I Fly First Class Announces Very Important New Tips and Regulation For Travelers
11. FDA, States Weigh Pharmacy Regulation in Wake of Meningitis Outbreak
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... It is vital for any lab to secure ... data. The team at Beckman Coulter has designed Kaluza, templates with advanced analytical tools ... need to operate in a GLP (Good Laboratory Practice) fashion. , With features designed ...
(Date:12/7/2016)... Boston, MA (PRWEB) , ... December 07, 2016 , ... ... They are sisters and wives, brothers and fathers, from New England and around ... illness and its stigma, and are brought together in a beautiful and compelling new ...
(Date:12/7/2016)... ... December 07, 2016 , ... Baciocco Brothers Insurance Agency, ... in the Sacramento/Folsom region, is initiating a charity event to raise support and ... Another Chance treatment center in Sacramento works to provide area teens and families ...
(Date:12/7/2016)... ... ... A. Kevin Spann Insurance, a New York-based firm offering insurance and financial ... charity drive to raise funds that will benefit the Marine Corps League. , The ... FMF Corpsmen. Working closely with the MCL, the A. Kevin Spann team plans to ...
(Date:12/7/2016)... ... 07, 2016 , ... Facial plastic surgeon, Dr. John D. Rachel of ... of proceeds to two local organizations: North Chicago Animal Control and Friends and Our ... a team of authorized and trained volunteers who support rescued animals held in the ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... PARK , Israel , December 7, ... announced today the signing of a memorandum of understanding with Korean ... synergy between the companies will assist in expediting Kadimastem,s entry into ... in innovative treatment for severe diseases in general and ALS and ... , , ...
(Date:12/7/2016)... , Dec. 7, 2016  Organovo Holdings, ... three-dimensional biology company focused on delivering scientific and ... announced that Chairman and Chief Executive Officer ... VirtualInvestorConferences.com on Wednesday, December 14, 2016 at 1:00 ... who are not yet familiar with the Company, ...
(Date:12/7/2016)... 7, 2016 The global  ... value of USD 3.9 billion by 2024, based ... Inc. The growth of the market is attributed ... technological advancements by the market players. Demand for ... increasing donation, rising awareness about transfusion-transmitted diseases, and ...
Breaking Medicine Technology: