Navigation Links
Erbitux Works Well for Two-Thirds of Colon Cancer Patients
Date:6/1/2008

e combination therapy as opposed to chemotherapy alone.

Since that time, the biology of KRAS has become better understood, and other studies have shown the value of the combination treatment as a third-line treatment. "Those with the KRAS mutation were resistant to cetuximab in third-line treatment," van Cutsem said.

Results were even clearer in the current set of findings, culled from tumor samples from 587 patients. Those with normal KRAS genes had a 32 percent reduced risk of developing a recurrence during the study period, compared with a 15 percent reduction for all patients.

"At one year, progression-free survival was 25 percent for those [taking chemotherapy alone] and 43 percent in the combination group," van Cutsem said. "In KRAS-mutant patients, there was no difference."

Also, 59.3 percent of normal gene patients responded to the combination treatment (tumors shrank by more than half), while only 43.2 percent of those on chemo alone responded. There were no differences in response rates among those with the mutation.

The study looked only at first-line treatment in patients with colorectal cancer which had already spread to other parts of their body. Side effects were "manageable," van Cutsem said.

"This is an exciting area of targeted agents," said Dr. Julie Gralow, moderator of the news conference at which the findings were presented and director of breast oncology at the University of Washington and Fred Hutchinson Cancer Center in Seattle. "The question is, how are we going to able to afford these drugs in these patients? It's exciting that KRAS seems to predict who will benefit. The wild-type is two-thirds of patients who will benefit. We don't need to give this drug to the other third now."

More information

The American Cancer Society has more on colon and rectum cancer.
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

0

GOOD

Page: 1 2 3

Related medicine news :

1. ImClone and Bristol-Myers Squibb Announce Joint Agreement With Merck KGaA to Co-Develop and Co-Commercialize ERBITUX(R) in Japan
2. In Combination With FOLFOX4, the Effect of Erbitux and Avastin On Survival Rates Will Drive Prescription Decisions in the Treatment of Stage III Colon Cancer
3. Erbitux Plus Chemo Improves Lung Cancer Outcomes
4. The Leukemia & Lymphoma Society Hosts Workshop On Weighing Treatment Options For Chronic Myelogenous Leukemia
5. Taxol bristle ball: a wrench in the works for cancer
6. Cancer control in Europe works; now it is time to extend it to poorer countries
7. SecureWorks Ranked 6th in Deloittes Technology Fast 50 Program for Georgia
8. AK Steel Reaches VEBA Health Care Settlement With Middletown Works Retirees
9. IOM workshop on less confusing drug labeling, Oct. 12
10. CIDM Collaborates With World Congress to Advance Dialog on Online Provider Networks at WHIT 3.0
11. Crittenton Hospital Medical Center to Participate in United Physicians myWorkspace(R) Initiative
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2009)... Skin Care Products from Episencial Offers Planet-Friendly Organics, Solar-Powered Manufacturing ... , ... Los Angeles, CA (PRWEB) December ... have an authentic, affordable choice in all natural skin care ... eponymous product line for young children featuring the beloved artwork ...
(Date:12/16/2009)... of Digital Pen and Paper technology and the provider of ... announced that it is ranked among the Fastest Growing Technology ... , ... (PRWEB) December 16, 2009 ... the capture, digitalization and management of handwritten data. Kayentis targets ...
(Date:12/16/2009)... 8 percent of children are uninsured, government report finds ... first six months of this year, 45.4 million Americans ... population -- had no health insurance, according to new ... addition, 58.4 million (19.4 percent) people of all ages ... year prior to the interview, and 31.9 million (10.6 ...
(Date:12/16/2009)... travel facilitator Companion Global Healthcare Inc. has accepted ... network of international hospitals that treat American patients ... U.S. facilities. ,, The announcement means Companion Global ... pricing for its individual clients and employer group ... Pablo Bayamon or HIMA San Pablo Caguas. ,, ...
(Date:12/16/2009)... Dec. 16 In a random sampling ... Portland, ME, and Philadelphia, PA, numerous pallets tested ... bacteria that could potentially create health hazards for ... of previous wood pallet testing conducted in the ... unacceptable risks to our nation,s food supply from ...
Breaking Medicine News(10 mins):Health News:New from Episencial: All Natural, Actively Healthy Skin Care for Babies, Kids and Planet Features Eric Carle's "The Very Hungry Caterpillar" 2Health News:New from Episencial: All Natural, Actively Healthy Skin Care for Babies, Kids and Planet Features Eric Carle's "The Very Hungry Caterpillar" 3Health News:New from Episencial: All Natural, Actively Healthy Skin Care for Babies, Kids and Planet Features Eric Carle's "The Very Hungry Caterpillar" 4Health News:New from Episencial: All Natural, Actively Healthy Skin Care for Babies, Kids and Planet Features Eric Carle's "The Very Hungry Caterpillar" 5Health News:With a Revenue Growth of Over 500% During the Last 5 Years, Kayentis is Ranked on the Deloitte Technology Fast 500 -- EMEA 2009 2Health News:Over 45 Million Americans Now Lack Health Insurance 2Health News:Hospitals in Puerto Rico Join Companion Global Healthcare's Network 2Health News:New Tests Confirm Wood Pallets Harbor Deadly Food Poisoning Bacteria 2Health News:New Tests Confirm Wood Pallets Harbor Deadly Food Poisoning Bacteria 3Health News:New Tests Confirm Wood Pallets Harbor Deadly Food Poisoning Bacteria 4
... 2007, 4:00 p.m. E.S.T. - Positron emission tomography (PET) ... for more accurate staging of lung cancer and improved ... online today in Journal of National Cancer Institute. ... Disease Site Group of Cancer Care Ontarios Program in ...
... shows young women are,dying of heart disease while the ... that preventive medical care is the most effective solution,to ... Fey, the,chairman and CEO of U.S. Preventive Medicine(R)., ... American College of,Cardiology revealed that more women under 45 ...
... who may need bone-strengthening therapies, experts say , , TUESDAY, ... a model to help doctors predict which postmenopausal women ... five-year period. , The algorithm includes 11 different factors ... applies to postmenopausal women of different ethnic backgrounds. ...
... Breast Cancer Risk Elevated in Male BRCA Mutation Carriers , ... greater risk of breast cancer than the general population. , Male ... cancers in the U.S., and it is most common in men ... that men who carry mutations in the BRCA2 gene have a ...
... Heavy smoking and drinking are known to cause ... 16 (HPV16), a common strain of the sexually-transmitted HPV ... neck cancer, which affects about 500,000 people each year ... alcohol and tobacco use doesnt further increase the risk ...
... be long gone, but that doesnt mean tobacco marketers have ... , A new Canadian study reports that tobacco marketers have ... marketing in retail shops located near high schools. The findings, ... strategy is working. , At the time of the ...
Other Medicine News:Health News:PET imaging significantly enhances standard imaging in lung cancer staging 2Health News:US Preventive Medicine(R) Says Study on Heart Disease-related Deaths Demonstrates Need for Preventive Medical Care 2Health News:US Preventive Medicine(R) Says Study on Heart Disease-related Deaths Demonstrates Need for Preventive Medical Care 3Health News:Criteria Predict Women's 5-Year Risk for Fracture 2Health News:Other Highlights in the Nov. 27 JNCI 2Health News:Other Highlights in the Nov. 27 JNCI 3Health News:Other Highlights in the Nov. 27 JNCI 4Health News:Drinking and smoking don't boost HPV-related cancer risk 2Health News:Tobacco marketers targeting teens near schools 2
(Date:12/16/2009)... A new application developed ... clinical review of specialty pharmaceuticals has increased health ... reviewed while reducing costs. ,, AIM, a leading ... health plan clients representing over 35 million consumers ... WLP ), adapted the successful clinical ...
(Date:12/16/2009)... 16 AVAX Technologies, Inc. (Pink Sheets: ... it recently closed a bridge loan financing (the ... Warrant Purchase Agreement (the "Agreement") with Firebird Global ... the Company sold a convertible promissory note, due ... of US$1,400,000, and issued a warrant to purchase ...
(Date:12/16/2009)... -- Boston Scientific Corporation (NYSE: BSX ) ... elected Nelda Connors as a Director. ,, ... Metal Products division of Tyco International. Previously, she ... positions in operations and general management. Prior to ... executive and management capacities with Ford, Chrysler and Mogami ...
Breaking Medicine Technology:American Imaging Management's New Specialty Drug Program Delivers Immediate Results 2American Imaging Management's New Specialty Drug Program Delivers Immediate Results 3American Imaging Management's New Specialty Drug Program Delivers Immediate Results 4AVAX Technologies, Inc. Closes Bridge Financing 2AVAX Technologies, Inc. Closes Bridge Financing 3AVAX Technologies, Inc. Closes Bridge Financing 4Boston Scientific Announces Election of Nelda Connors to Its Board of Directors 2Boston Scientific Announces Election of Nelda Connors to Its Board of Directors 3Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells 10101 1Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells 10101 2Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells 10101 3Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells 10101 4Saint Louis Public School District Awards Contract to Accelify 58302 1Saint Louis Public School District Awards Contract to Accelify 58302 2Corn Refiners Association Comments on Findings in Recent Report on Sugars and High Blood Pressure 58297 1Corn Refiners Association Comments on Findings in Recent Report on Sugars and High Blood Pressure 58297 2
... 9 Sequoia Pharmaceuticals presented,positive results today ... volunteers and,preclinical studies on SPI-452, a novel ... Pharmacokinetic enhancers increase drug levels of,co-administered agents ... These increased drug levels can lead to ...
... The U.S. Agency for International Development (USAID) ... who are in the midst of an expanding humanitarian ... epidemic have left the people of Zimbabwe in danger ... Malaria Initiative, is supporting emergency Indoor Residual Spraying (IRS) ...
Other Medicine Technology:Sequoia Pharmaceuticals Presents Proof of Clinical Concept of SPI-452, a Novel Pharmacokinetic Enhancer 2Sequoia Pharmaceuticals Presents Proof of Clinical Concept of SPI-452, a Novel Pharmacokinetic Enhancer 3Sequoia Pharmaceuticals Presents Proof of Clinical Concept of SPI-452, a Novel Pharmacokinetic Enhancer 4Sequoia Pharmaceuticals Presents Proof of Clinical Concept of SPI-452, a Novel Pharmacokinetic Enhancer 5USAID Provides Malaria Assistance to Zimbabwe 2
... products are offered as 1-piece or modular, ... modular instruments may be customized with handles ... ratchets, insulation and flush ports. Many standard ... specifications may affect delivery times. , ...
... offered as 1-piece or modular, in regular ... may be customized with handles of choice ... and flush ports. Many standard patterns are ... affect delivery times. , Please Note: ...
... The Featured Products ... at Mediflex and are ... modular in regular or ... come equipped with insulation, ...
... Products are kept in ... are offered as 1-piece ... or extra long lengths. ... insulation, flush ports, rotating ...
Medicine Products: