Navigation Links
Equality of the sexes? Not always when it comes to biology
Date:5/11/2009

This release is available in French.

Montreal, May 11, 2009 When it comes to immunity, men may not have been dealt an equal hand. The latest study by Dr. Maya Saleh, of the Research Institute of the McGill University Health Centre and McGill University, shows that women have a more powerful immune system than men. In fact, the production of estrogen by females could have a beneficial effect on the innate inflammatory response against bacterial pathogens. These surprising results were published today in the Proceedings of the National Academy of Sciences.

More specifically, estrogen naturally produced in women seems to block the production of an enzyme called Caspase-12, which itself blocks the inflammatory process. The presence of estrogen would therefore have a beneficial effect on innate immunity, which represents the body's first line of defence against pathogenic organisms. "These results demonstrate that women have a more powerful inflammatory response than men," said Dr. Saleh.

This study was conducted on mice that lack the Caspase-12 gene, meaning that the mice were extremely resistant to infection. The human Caspase-12 gene was implanted in a group of male and female mice, yet only the males became more prone to infection. "We were very surprised by these results, and we determined that the estrogen produced by the female mice blocked the expression of the human Caspase-12 gene," explained Dr. Saleh. "We were also able to locate where the estrogen receptor binds on the gene in order to block its expression, which indicates that the hormone exerts direct action in this case."

Since these experiments were conducted using a human gene, the researchers consider these results to be applicable to humans. This feature of the female innate immune system might have evolved to better protect women's reproductive role.


'/>"/>
Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-843-1560
McGill University Health Centre
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pitt study finds inequality in tobacco advertising
2. Income inequality associated with overnourishment and undernourishment in India
3. Risk of disability rises in states with income inequality
4. Low standards of child well-being linked to greater income inequality
5. Blood pressure control inequality linked to deaths among blacks
6. In New Jersey, a Blue-Ribbon State Government Commission Tells Governor Corzine and the Legislature: Its Time to Enact Marriage Equality
7. Project 515 Proposes Legislation to Ensure Equality During Times of Illness and Death
8. Obesity Doesnt Always Equal Diabetes
9. Consumer Reports Analysis: Drugs for Nerve Pain, Fibromyalgia Effective, But Not Always Best
10. Antibiotics Not Always Best Bet for Battling Childhood Ear Infections
11. Announcing Always Best Care Senior Services Expansion Into San Joaquin County, California
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 17, 2014 In its comprehensive analysis ... its Argus Claim Review division have recently identified out-of-network ... common ways savings are achieved on behalf of employer-clients. ... of dollars in savings to Argus each year, with ... As explained by Tom Doney, Cypress president and CEO, ...
(Date:12/17/2014)... December 17, 2014 Now in its ... the best of the best in senior living and ... only given to communities and agencies that have received ... site. Of the nearly 100,000 providers currently listed on ... of the SeniorAdvisor.com Best of 2015 Awards are located ...
(Date:12/17/2014)... 15, 2014 (HealthDay News) -- As gas prices rose ... a new study suggests. In times of gas ... those riders are inexperienced, the researchers explained. They ... which has the highest number of motorcycle registrations in ... motorcyclist deaths. The analysis revealed a strong association ...
(Date:12/17/2014)... Expectant parents should leave prenatal picture-taking to medical professionals, ... of ultrasound imaging and heartbeat monitors to get "keepsake" ... warns. "Although there is a lack of ... heartbeat monitors, prudent use of these devices by trained ... biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... -- Greater participation in music classes may benefit children,s ... kids in the nonprofit Harmony Project, which provides music ... Over two years, children who actively participated in ... processes speech and reading, compared to those with lower ... participation in music classes occurred in the same areas ...
Breaking Medicine News(10 mins):Health News:Out-of-Network & Medical Necessity Reviews among Top Ways TPA Identifies Significant Medical Claim Savings 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 3Health News:When Gas Prices Go Up, So Do Motorcycle Accidents, Study Finds 2Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Music Classes Boost Language Skills, Study Says 2
... (May 1, 2011) -- A drug commonly used to treat ... according to a study published in the May issue of ... kinase inhibitor, blocks the action of mammalian target of rapamycin ... tumor growth. It,s used to treat advanced renal cell carcinoma. ...
... ATHENS, Ohio (April 30, 2011) The Osteopathic Heritage Foundations, ... represents the largest private donation ever given to a college ... to address some of the most pressing health care issues ... of primary care physicians and the diabetes epidemic. The ...
... HealthDay Reporter , FRIDAY, April 29 (HealthDay News) -- ... debate on whether or not American women should begin regular ... the annual meeting of the American Society of Breast ... to 49 with mammograms detected smaller breast cancers, with less ...
... in the emergency department (ED) complaining primarily of lower ... tested for sexually transmitted infections (STIs), according to the ... 30, at the Pediatric Academic Societies (PAS) annual meeting ... when adolescents seek treatment for symptoms suggestive of an ...
... from elevated anxiety. Patient discomfort may cause poor ... Anxiolytic medications are currently used to reduce this ... non-invasive alternative treatment with fewer adverse effects, according to ... Ray Society,s annual meeting. The project was conceived ...
... April 29 (HealthDay News) -- Multiple pregnancies may increase ... plaque in the arteries, suggests new research in mice. ... studied mice late in gestation in either their first ... severe glucose intolerance and excess fat tissue, while those ...
Cached Medicine News:Health News:Renal cancer drug temsirolimus shows promise against mesothelioma 2Health News:Record funding award given to Ohio University College of Osteopathic Medicine 2Health News:Record funding award given to Ohio University College of Osteopathic Medicine 3Health News:Record funding award given to Ohio University College of Osteopathic Medicine 4Health News:Record funding award given to Ohio University College of Osteopathic Medicine 5Health News:Mammograms Can Save Lives of Women in Their 40s: Studies 2Health News:Mammograms Can Save Lives of Women in Their 40s: Studies 3Health News:Mammograms Can Save Lives of Women in Their 40s: Studies 4Health News:EDs should be aware of sexually transmitted infection risk in patients 2Health News:Animal-assisted therapy decreases patient anxiety in pre-MRI setting, study suggests 2
(Date:12/17/2014)... KENNESAW, Ga. and RALEIGH, ... Clinical Trial Marketing Communications, LLC (CTMC), and Integrated ... in patient recruitment and retention for clinical trials ... called Integrated Clinical Trial Marketing Services (i-CTMS). i-CTMS ... and retention services to pharmaceutical, biotechnology and medical ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... of the "Inferior Vena Cava (IVC) Filters - ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... is projected to reach US$435 million by 2016. The ... 39% (2015) of the global value while ...
(Date:12/15/2014)... BRIDGEWATER, N.J. , Dec. 15, 2014   ... SAN and NYSE: SNY) are collaborating with nationally-recognized patient ... Counts , an awareness program that will gauge how ... risks associated with high LDL-C (bad cholesterol).  American adults ... to take a brief poll and answer a few ...
Breaking Medicine Technology:Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 2Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 4Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 2Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 3Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 4Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 5Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 6
... begin Phase IIb study in the first half of ... (Nasdaq: ALSE ), announced today that it has,concluded ... in acute,spinal cord injury (SCI). A total of 48 ... States and Canada. We expect to release periodic,updates of ...
... PHILLIPSBURG, N.J., Jan. 7 Celldex Therapeutics,announced today ... has,granted Fast Track designation to Celldex,s CDX-110 for ... is the most common,and aggressive form of primary ... current therapy. CDX-110 is an immunotherapy that targets,the ...
Cached Medicine Technology:Alseres Pharmaceuticals Concludes Enrollment in the Cethrin(R) Phase I/IIa Clinical Trial in Acute Spinal Cord Injury 2Alseres Pharmaceuticals Concludes Enrollment in the Cethrin(R) Phase I/IIa Clinical Trial in Acute Spinal Cord Injury 3Alseres Pharmaceuticals Concludes Enrollment in the Cethrin(R) Phase I/IIa Clinical Trial in Acute Spinal Cord Injury 4Alseres Pharmaceuticals Concludes Enrollment in the Cethrin(R) Phase I/IIa Clinical Trial in Acute Spinal Cord Injury 5Celldex Therapeutics Receives Fast-Track Designation for CDX-110, a Novel EGFRvIII Vaccine for Glioblastoma 2Celldex Therapeutics Receives Fast-Track Designation for CDX-110, a Novel EGFRvIII Vaccine for Glioblastoma 3Celldex Therapeutics Receives Fast-Track Designation for CDX-110, a Novel EGFRvIII Vaccine for Glioblastoma 4Celldex Therapeutics Receives Fast-Track Designation for CDX-110, a Novel EGFRvIII Vaccine for Glioblastoma 5
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: