Navigation Links
Epstein-Barr: a virtual look at a vexing virus
Date:10/22/2007

BOSTON (October 22, 2007) Researchers at Tufts University School of Medicine in collaboration with the Virginia Bioinformatics Institute at Virginia Tech have created a computer program called Pathogen Simulation (PathSim) to study the progression of Epstein-Barr virus (EBV) in humans. David Thorley-Lawson, PhD, professor of pathology at Tufts University School of Medicine, is combining PathSim, laboratory methods, and clinical studies to provide a new and powerful approach to understanding EBV and ultimately designing anti-viral therapies.

PathSim is an agent-based computer program. The agents are the virus itself, and the T and B cells of the patients immune system, explains Thorley-Lawson. Using PathSim, Thorley-Lawson can manipulate these agents to simulate EBV infection and persistence in humans. EBV can infect one person and remain latent not cause any symptoms. It can infect another person and cause infectious mononucleosis, or, in rare cases, cancer, like Hodgkins, Burkitts, and immunoblastic lymphomas, says Thorley-Lawson.

Scientists can use PathSim like a video game and change variables, such as number of virus particles or characteristics of the patients immune cells, to follow the course of disease and observe what drives the virus to either latency or illness.

We validated PathSim by comparing it to EBV infection in patients, says Thorley-Lawson. For example, PathSim projected that the peak in the number of infected immune cells, called B cells, would occur 33 through 38 days post-infection, which is consistent with the peak of 35 through 50 days actually seen in infected patients. This consistency is important because it validates the predictive power of PathSim; the power to reveal what EBV is doing in a patients body, says Thorley-Lawson.

It takes one full week to run one simulation, says Thorley-Lawson. Then we compile the data and look for critical switch points of disease. A switch point is a small change in the behavior of an agent that can influence the progression of disease. Such a change may determine whether the virus persists in the body in a latent state, or causes illness and even death by replicating out of control. Once these critical switch points are understood, biologists may be able to develop drugs that target specific points in the interaction between the virus and immune system at specific times, explains Thorley-Lawson. The more targeted the drug, the more safe and effective the resulting therapy. We hope that this marriage of computers and biology will eventually lead to better patient treatment against EBV.


'/>"/>

Contact: Siobhan Gallagher
siobhan.gallagher@tufts.edu
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert

Related medicine news :

1. New virtual colonoscopy procedure for easier colon screening
2. Stanford Medical Center Implements The First Virtual Cardiac Ultrasound
3. Virtual Colonoscopy May Be Better Than Real-time Colonoscopy
4. Virtual Reality For Treating Stress Disorders
5. Hip Replacement Can Now Be Performed On Virtual Patients
6. Virtual Reality Simulation Could Help In Training Surgeons
7. New Studies Show The Efficacies Of Virtual Realities Vis-à-vis Pai
8. Virtual Meeting Place Unites Patients with Brain Tumors and Neurosurgical Disorders
9. Virtual Colonoscopy in Colorectal Cancer Prevention and Screening
10. The Tech Savvy Patient Knocks on the Doors of Telemedicine and Virtual Clinics
11. Virtual Colonoscopy is Most-effective for Screening Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson Insurance and ... and financial preparation services, is providing an update on a charitable event that ... City Rescue is a locally recognized nonprofit that provides shelter and care for ...
(Date:10/13/2017)... ... 2017 , ... The International Association of Eating Disorders Professionals ... the field of eating disorders, announces the opening of early registration for the ... at the Omni Resort at ChampionsGate. , The annual iaedp™ Symposium ...
(Date:10/13/2017)... Shelton, CT (PRWEB) , ... October 13, 2017 , ... ... and long-term care services, staged a mock evacuation of the facility as part of ... Department, Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun ... NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is ... is geared towards children of all ages; it is a non-competitive, non-timed event, which ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... 2017  South Korean-based healthcare product Development Company I.M. ... on Kickstarter. The device will educate the user about ... better efficiency compared to the dated and pricey CPR ... efficacy of the compression for a more informed CPR ... to raise $5,000. ...
(Date:10/4/2017)... , Oct. 4, 2017 ... single-use, self-contained, illuminating medical devices, today announced regulatory ... Health Surveillance Agency (or Agência Nacional de Vigilância ... first single-use, cordless surgical retractor with integrated LED ... optimal access, illumination and exposure of a tissue ...
(Date:10/2/2017)... 2, 2017  Eli Lilly and Company (NYSE: ... the third quarter of 2017 on Tuesday, October 24, ... that day with the investment community and media to ... conference call will begin at 9 a.m. Eastern time. ... live webcast of the conference call through a link ...
Breaking Medicine Technology: