Navigation Links
Epstein-Barr: a virtual look at a vexing virus
Date:10/22/2007

BOSTON (October 22, 2007) Researchers at Tufts University School of Medicine in collaboration with the Virginia Bioinformatics Institute at Virginia Tech have created a computer program called Pathogen Simulation (PathSim) to study the progression of Epstein-Barr virus (EBV) in humans. David Thorley-Lawson, PhD, professor of pathology at Tufts University School of Medicine, is combining PathSim, laboratory methods, and clinical studies to provide a new and powerful approach to understanding EBV and ultimately designing anti-viral therapies.

PathSim is an agent-based computer program. The agents are the virus itself, and the T and B cells of the patients immune system, explains Thorley-Lawson. Using PathSim, Thorley-Lawson can manipulate these agents to simulate EBV infection and persistence in humans. EBV can infect one person and remain latent not cause any symptoms. It can infect another person and cause infectious mononucleosis, or, in rare cases, cancer, like Hodgkins, Burkitts, and immunoblastic lymphomas, says Thorley-Lawson.

Scientists can use PathSim like a video game and change variables, such as number of virus particles or characteristics of the patients immune cells, to follow the course of disease and observe what drives the virus to either latency or illness.

We validated PathSim by comparing it to EBV infection in patients, says Thorley-Lawson. For example, PathSim projected that the peak in the number of infected immune cells, called B cells, would occur 33 through 38 days post-infection, which is consistent with the peak of 35 through 50 days actually seen in infected patients. This consistency is important because it validates the predictive power of PathSim; the power to reveal what EBV is doing in a patients body, says Thorley-Lawson.

It takes one full week to run one simulation, says Thorley-Lawson. Then we compile the data and look for critical switch points of disease. A switch point is a small change in the behavior of an agent that can influence the progression of disease. Such a change may determine whether the virus persists in the body in a latent state, or causes illness and even death by replicating out of control. Once these critical switch points are understood, biologists may be able to develop drugs that target specific points in the interaction between the virus and immune system at specific times, explains Thorley-Lawson. The more targeted the drug, the more safe and effective the resulting therapy. We hope that this marriage of computers and biology will eventually lead to better patient treatment against EBV.


'/>"/>

Contact: Siobhan Gallagher
siobhan.gallagher@tufts.edu
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert

Related medicine news :

1. New virtual colonoscopy procedure for easier colon screening
2. Stanford Medical Center Implements The First Virtual Cardiac Ultrasound
3. Virtual Colonoscopy May Be Better Than Real-time Colonoscopy
4. Virtual Reality For Treating Stress Disorders
5. Hip Replacement Can Now Be Performed On Virtual Patients
6. Virtual Reality Simulation Could Help In Training Surgeons
7. New Studies Show The Efficacies Of Virtual Realities Vis-à-vis Pai
8. Virtual Meeting Place Unites Patients with Brain Tumors and Neurosurgical Disorders
9. Virtual Colonoscopy in Colorectal Cancer Prevention and Screening
10. The Tech Savvy Patient Knocks on the Doors of Telemedicine and Virtual Clinics
11. Virtual Colonoscopy is Most-effective for Screening Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... Guide to ... , No matter on which side of the Atlantic devicemakers do business, ... regulations they have to follow. , In addition to the full text of the ...
(Date:6/28/2017)... ... June 28, 2017 , ... Anyone with a remote control has seen the never-ending twists ... you the flipper will get rich in no time. But what about the buyers ... get for the buyer of a flipped house. An email recently sent to Gary ...
(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... David B. Sosin, a founding ... Illinois, took over the post of 2nd Vice President for the Illinois State Bar ... installed as the ISBA’s 3rd Vice President in 2016 following a state-wide election and served ...
(Date:6/28/2017)... ... ... American Farmer proudly announces the participation of Pure Line Seeds, Inc (Pure ... broadcast fourth quarter 2017. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , Founded ... As demand grew, the small company located in Moscow, Idaho extended its sales from ...
(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... ... ZEON) is pleased to announce that a two year study conducted by the ... Bromley Creek zeolite was successful in remediating potash brine-impacted groundwater. As a part ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... CALABASAS, Calif. , June 14, 2017 ... with the City of Fremont ... chain of the bio-pharma industry in California ... sharing technology, enabling executive networking, and fostering workforce development. ... the development and growth of start-ups, as well as ...
(Date:6/11/2017)... , June 10, 2017  Eli Lilly and Company (NYSE: ... three Phase 3 studies of galcanezumab, an investigational treatment ... late-breaking data on several key secondary endpoints for galcanezumab ... from these studies (EVOLVE-1, EVOLVE-2 and REGAIN) will be ... scientific meeting in Boston . ...
(Date:6/8/2017)... MAITLAND, Fla. , June 8, 2017  Less ... ransomware attack that hit more than 200,000 companies, including hospital ... is being heralded as one of the largest online ... technology in the healthcare market, it is imperative that ... can protect their data from this — and many ...
Breaking Medicine Technology: