Navigation Links
Epoxide hydrolase inhibition and Thiazolidinediones: A therapy for cardiometabolic syndrome
Date:4/23/2013

Scientists at the Medical College of Wisconsin and the University of California at Davis, led by Dr. John Imig and Dr. Bruce Hammock have determined the synergistic actions of inhibiting soluble epoxide hydrolase (sEH) with tAUCB (trans-4-(4-[3-adamantan-1-yl-ureid]-cyclohexyloxy)-benzoic acid) and activating peroxisome proliferator-activator receptorγ (PPARγ) with the thiazolidinedione rosiglitazone on the pathological progression of cardiometabolic syndrome. Cardiometabolic syndrome occurs with obesity and hypertension increasing the risks for cardiovascular disease and causing significant and rapidly progressive kidney disease. The findings, which appear in the December 2012 issue of Experimental Biology and Medicine, demonstrate that sEH inhibition and PPARγ activation in combination had the greatest beneficial effects on the multi-disease features and progression of kidney disease associated with cardiometabolic syndrome.

"Inhibitors of sEH have recently reached a point where their ability to combat cardiovascular and kidney diseases can be determined in humans", states Dr. Imig. "In this study we show that when used in combination with a PPARγ agonist therapy for cardiometabolic syndrome that there is a synergistic effect to decrease cardiovascular risk factors and progressive kidney disease. Another potential positive aspect of this combination therapy is that sEH inhibition has beneficial actions to counteract the edema and congestive heart failure that occurs in patients treated long-term with PPARγagonists."

Future studies would include combinational chemistry approaches to design and synthesize drugs with dual sEH inhibitory and PPARγ agonistic activities. Dr. Hammock states, "these approaches are currently being done by his laboratory and others". He also says "that combining sEH inhibition not just with PPARγ but also with other therapies for cardiovascular, inflammatory, and renal diseases are on the horizon and have therapeutic potential as both drug combinations and dual sEH inhibitors with PPARγ activity for treating cardiometabolic syndrome."

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said, " This study by John Imig and Bruce Hammack, performed on spontaneous hypertensive and spontaneous hypertensive obese rat models, suggests that a combined therapy with epoxide hydrolase inhibitors and thiazolidinediones may prove to be efficacious in treatment of the multi-disease characteristics of cardiometabolic syndrome. "


'/>"/>

Contact: John Imig
jdimig@mcw.edu
Society for Experimental Biology and Medicine
Source:Eurekalert

Related medicine news :

1. Neurological Wellness Center's Novel Neuro-Inflammation Inhibition Procedure that Induces Rapid Recovery from Alzheimer's, Stroke and Brain Injury is Now Being Taught in a Newly Released Video
2. Novel test identifies patients most likely to benefit from ALK inhibition therapy
3. Treating drug resistant cancer through targeted inhibition of sphingosine kinase
4. Specific inhibition of autophagy may represent a new concept for treatment of kidney cancer
5. Palliative radiotherapy for bone metastases in elderly patients improves quality of life
6. Physical Therapy Exercises
7. How “Post Rehab Essentials” Helps People Learn About Post Rehab – V kool
8. Intensity modulated radiotherapy reduces side effects in patients with early breast cancer
9. New radiotherapy approach reduces symptoms of dry mouth in patients with head and neck cancers
10. 2 landmark studies report on success of using image-guided brachytherapy to treat cervical cancer
11. Early cognitive behavioural therapy reduces risk of psychosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... Cranbury, NJ (PRWEB) , ... January 17, 2017 ... ... television personality, and breast cancer survivor Sandra Lee as keynote speaker for the ... Miami Beach, Florida. , In making the announcement, PER® president, Phil Talamo, said, ...
(Date:1/17/2017)... York, NY (PRWEB) , ... January 17, 2017 ... ... Inc. Magazine’s fastest-growing private companies and ranked among the top US security companies ... Board of Directors. This announcement brings a year-long independent board nomination process ...
(Date:1/17/2017)... ... 17, 2017 , ... Today, FloSports , a global leader in live ... as part of a long-term extension of their media partnership. The partnership, which began ... of the sport’s premier events exclusively on FloWrestling.com as well as usage of the ...
(Date:1/16/2017)... ... January 17, 2017 , ... ... Pain, an internationally recognized leader in the fast-casual category, announces a hearty and ... the Good Egg Breakfast Sandwich, Turkey Mash-Up Sandwich, Cranberry Crunch & Honey Parfait, ...
(Date:1/16/2017)... ... January 16, 2017 , ... California Southern University has named Dr. Steven ... Board of Trustees and as a core faculty member, teaching master’s and doctoral courses ... of psychology at Pepperdine University, where he earned his Doctor of Psychology degree in ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... Future published a Half Cooked Research Report on Endoscopy Devices Market. ... million during the period 2016 to 2022 from USD 28.7 million ... ... as a swiftly growing market and expected to grow at a ... various regions.  The increasing growth in endoscopy procedures is influencing the ...
(Date:1/17/2017)... 17, 2016  Attorney Advertising -- Bronstein, Gewirtz & Grossman, ... Anthera Pharmaceuticals, Inc. ("Anthera" or the "Company") (NASDAQ: ... and assist the investigation by visiting the firm,s site: ... certain of its officers and/or directors have violated Sections 10(b) ... ...
(Date:1/17/2017)... 17, 2017  In a letter to President-elect ... Jenkins outlines AARP,s priorities for Americans age 50 ... access to affordable health care coverage, and lowering the ... Jenkins writes to President-elect Trump that "Our nearly 38 ... on you to protect their Medicare and Social Security ...
Breaking Medicine Technology: