Navigation Links
Epilepsy marked by neural 'hub' network
Date:3/25/2008

Irvine, Calif., March 25, 2008 An increased number of neuron hubs in the epileptic brain may be the root cause for the seizures that characterize the disorder, according to a UC Irvine study.

Researchers Robert Morgan and Ivan Soltesz with the Department of Anatomy and Neurobiology identified that these hubs a small number of highly connected neurons are formed in the hippocampus during the transition from a healthy brain to an epileptic one. The increased number of connections among these hubs, they found, circulate and amplify signals to such a degree that they overwhelm brain networks, leading to epileptic seizures.

The study appears this week in the online early edition of the Proceedings of the National Academy of Sciences.

The structure of the epileptic brain differs substantially from that of a healthy one, and our discovery of this hub network offers insight into how epilepsy may develop, Morgan said. By establishing therapeutic measures that can selectively target these hub cells, we may be able to create a treatment for epilepsy.

The researchers used a computer model of a moderately injured hippocampus the brain region involved in many forms of epilepsy to create the signaling networks that mimic an epileptic brain, and they found that one featuring a greater number of neuronal hubs promoted the onset of seizure.

By comparing this model with previous animal model studies of epilepsy, they identified these hubs as the network conduits for seizures. Soltesz said that previous studies revealed the existence of these hubs but did not define their role.

This study is a great example of integrating data from biomedical informatics with basic and clinical research to advance the effort to understand and potentially treat disease and disorders like epilepsy, added Soltesz, who is chair of the anatomy and neurobiology department and a member of UC Irvines Epilepsy Research Center.

Epilepsy affects more than 2 million individuals of all ages in the U.S. alone and at least 50 million worldwide. It is characterized by the occurrence of spontaneous, unpredictable seizures, which can interfere with daily life, be dangerous, and lead to death of some brain cells. While much information is available about the abnormal communication of neuronal networks in epilepsy, the basic mechanisms, involving both genetic and acquired elements, are not fully understood.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. Senior Obama Strategist David Axelrod and Wife Susan to be Honored for Their Decade-Long Commitment to Epilepsy Research at NYC Benefit
2. Idaho Youth Named National Epilepsy Spokesperson
3. Florida Youth Named National Epilepsy Spokesperson
4. Delaware Youth Named National Epilepsy Spokesperson
5. Colorado Youth Named National Epilepsy Spokesperson
6. Arizona Youth Named National Epilepsy Spokesperson
7. Washington Youth Named National Epilepsy Spokesperson
8. Vermont Youth Named National Epilepsy Spokesperson
9. Wisconsin Youths Named National Epilepsy Spokespersons
10. Virginia Youth Named National Epilepsy Spokesperson
11. Utah Youth Named National Epilepsy Spokesperson
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... This Saturday, ... & magic, plus a very special performance by Alabama Symphony Orchestra musicians Yifan Zhou, ... their specialties, such as dim sum, and exhibitors offer a look at Chinese games, ...
(Date:1/24/2017)... ... January 24, 2017 , ... The results from the American ... particularly good news for prostate cancer patients: incidents of cancer is down as is ... report the cancer death rate has dropped from its peak of 215.1 in 1991 ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... officially unveiled its latest award-winning bottles, designed specifically to optimize the drinking experience ... Taza Agua is renowned for introducing the world’s first untouched bottled water purposed ...
(Date:1/24/2017)... ... 24, 2017 , ... “Choosing Wisdom-Solomon’s Proverbs Reclaimed”: an ... gossip, prostitution, adultery, anger, and common sense. , “Choosing Wisdom-Solomon’s Proverbs Reclaimed” ... David Coats. In September of 1983, they flew to Haiti to focus on ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... “The Octagon ... balance. “The Octagon of Spiritual Balances” is the creation of published author, Pastor Bernard ... Bernard J. Weathers holds a bachelor degree in religious education and a master degree ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... PUNE, India , January 24, 2017 /PRNewswire/ ... Market Research, titled, "Cold Chain Logistics Market by Application ... Frozen Dessert, Meat, Fish & Sea Food, Drugs & ... Forecasts, 2014-2022," projects that the global cold chain logistics ... growing at a CAGR of 16% (2016 to 2022). ...
(Date:1/24/2017)... , Jan. 24, 2017 Regeneron Pharmaceuticals, Inc. ... Public today recognized 40 finalists in the Regeneron Science ... and math competition for high school seniors. Finalists were ... of their research projects. The finalists will ... from March 9-15 to undergo a rigorous judging process ...
(Date:1/24/2017)... 24, 2017 Research and Markets has announced ... Trends - Product, Material - Forecast to 2025" report to ... ... a CAGR of around 5.4% over the next decade to reach ... trends that the market is witnessing include 3D medical printing is ...
Breaking Medicine Technology: