Navigation Links
Epilepsy marked by neural 'hub' network
Date:3/25/2008

Irvine, Calif., March 25, 2008 An increased number of neuron hubs in the epileptic brain may be the root cause for the seizures that characterize the disorder, according to a UC Irvine study.

Researchers Robert Morgan and Ivan Soltesz with the Department of Anatomy and Neurobiology identified that these hubs a small number of highly connected neurons are formed in the hippocampus during the transition from a healthy brain to an epileptic one. The increased number of connections among these hubs, they found, circulate and amplify signals to such a degree that they overwhelm brain networks, leading to epileptic seizures.

The study appears this week in the online early edition of the Proceedings of the National Academy of Sciences.

The structure of the epileptic brain differs substantially from that of a healthy one, and our discovery of this hub network offers insight into how epilepsy may develop, Morgan said. By establishing therapeutic measures that can selectively target these hub cells, we may be able to create a treatment for epilepsy.

The researchers used a computer model of a moderately injured hippocampus the brain region involved in many forms of epilepsy to create the signaling networks that mimic an epileptic brain, and they found that one featuring a greater number of neuronal hubs promoted the onset of seizure.

By comparing this model with previous animal model studies of epilepsy, they identified these hubs as the network conduits for seizures. Soltesz said that previous studies revealed the existence of these hubs but did not define their role.

This study is a great example of integrating data from biomedical informatics with basic and clinical research to advance the effort to understand and potentially treat disease and disorders like epilepsy, added Soltesz, who is chair of the anatomy and neurobiology department and a member of UC Irvines Epilepsy Research Center.

Epilepsy
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Senior Obama Strategist David Axelrod and Wife Susan to be Honored for Their Decade-Long Commitment to Epilepsy Research at NYC Benefit
2. Idaho Youth Named National Epilepsy Spokesperson
3. Florida Youth Named National Epilepsy Spokesperson
4. Delaware Youth Named National Epilepsy Spokesperson
5. Colorado Youth Named National Epilepsy Spokesperson
6. Arizona Youth Named National Epilepsy Spokesperson
7. Washington Youth Named National Epilepsy Spokesperson
8. Vermont Youth Named National Epilepsy Spokesperson
9. Wisconsin Youths Named National Epilepsy Spokespersons
10. Virginia Youth Named National Epilepsy Spokesperson
11. Utah Youth Named National Epilepsy Spokesperson
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... 2015 Software and Cybersecurity Risk ... and Best Practices for Compliance, **Presented by FDAnews ... http://www.fdanews.com/CybersecurityMDWorkshop , This workshop — chaired ... been specifically designed to provide attendees with industry ... medical device software safety. , In fact, it's ...
(Date:3/30/2015)... Garden City, NY (PRWEB) March 31, 2015 ... as a 2015 Professional Woman of the Year. ... leadership in business. As the largest, most-recognized networking organization ... industry and profession, the National Association of Professional Women ... members and over 200 Local Chapters. , “I take ...
(Date:3/30/2015)... NASHVILLE, Tenn. (PRWEB) March 30, 2015 ... the third annual Hike2Heal 5k to raise funds to ... Roof Academy in Uganda. Hike2Heal will take place on ... Park at shelter No. 9 on 86 Vaughn Road ... Uganda, is located in an area without reliable medical ...
(Date:3/30/2015)... March 30, 2015 Good Shepherd Children’s Home ... Children’s Home in Murfreesboro provides a Christian-based home, the children ... Christ and his special plan for their life. , ... new day begins as, one-by-one, the children begin to awake ... as the alarm continues to buzz. Sleepily, she crawls ...
(Date:3/30/2015)... Healtheminds, a start-up focusing on providing high quality ... to use and engaging online platform, is launching a ... related issues. The first in the series is a ... drugs. , Consumption and use of alcohol and ... toxic effects of excessive intake or drug overdoses, accidental ...
Breaking Medicine News(10 mins):Health News:FDAnews Announces New Dates — Software and Cybersecurity Risk Management for Medical Devices Workshop, May 11-12, 2015 2Health News:FDAnews Announces New Dates — Software and Cybersecurity Risk Management for Medical Devices Workshop, May 11-12, 2015 3Health News:FDAnews Announces New Dates — Software and Cybersecurity Risk Management for Medical Devices Workshop, May 11-12, 2015 4Health News:National Association of Professional Women Announces Stacey Lynne Irey, Office Manager at Mid Jersey Endodontic Group, a 2015 Professional Woman of the Year 2Health News:Hike2Heal and Rethink Church Raise Funds To Provide Healthcare for Ugandan Children with 3rd Annual Raise the Roof 5K on April 18 2Health News:Good Shepherd Children’s Home Announces 53rd Year of Providing a Safe-Haven for Children in Need 2Health News:HealthEminds Launching Webinar on Drug Dependence 2
... And thanks to tight jeans. So says a study conducted by ... ,A ten-year study by the premier medical institution actually reveals ... count of a normal adult male in India has plunged to ... around 30 years ago. ,And this relatively swift decline ...
... the Government’s decision to officially recognise the Australian College ... rural GPs. ,“Rural GPs are the backbone ... ,“Formal recognition for rural GPs who complete the ... in rural and regional areas.” ,The Australian ...
... and coastal areas is a vital part of the ... according to the IUCN World Conservation Union. ... marine protection if we are to support the global ... Julia Marton-Lefevre at a summit on ocean conservation here. ...
... donors, Ontario’s health ministry is considering// the plan of reimbursement ... The health minister has promised to take a stand ... up nearly $5,500 as expense for people who go the ... 43 living donors have been reimbursed their expenses. , ...
... space with stories on bird flu. After all, it is ... pets may be the only ones who need to be ... an arsenic-based additive that forms an ingredient in chicken feed ... chicken. , ,Roxarsone, the wide spread arsenic-based additive ...
... given us adequate reasons to make fish a part of ... in fish has always hogged the spotlight for its health ... researchers suggest that Omega -3 rich seafood could protect against ... and cognitive function of 210 men, between the ages of ...
Cached Medicine News:Health News:Denim Lovers Beware, Fertility Could Be in Danger, Says a New Study 2Health News:Protecting Oceans is Important to Keeping Planet Cool 2
(Date:3/30/2015)... 30, 2015 Perrigo Company plc (NYSE: ... Affordable Healthcare Products®," today announced that it has completed ... in a cash and equity transaction valued at approximately ... in debt. Sellers are Marc Coucke , Waterland ...   "The combination of Perrigo ...
(Date:3/30/2015)...  MedAptus® today announced the launch of Assign, ... needs for busy inpatient provider teams. Assign was ... to hospitalists or other rounding providers based on ... such as ensuring patient safety, proper reimbursement and ... In an increasingly risk-based healthcare ...
(Date:3/30/2015)... CHARLOTTE, N.C. , March 30, 2015 /PRNewswire/ ... today announced a worldwide search for product innovations ... The most promising ideas uncovered during the 8-week ... partners for potential commercialization.  Invention ideas can be ... www.EdisonNationMedical.com/Mobility now through May 28, 2015. ...
Breaking Medicine Technology:Perrigo Company plc Completes Acquisition Of Omega Pharma Invest N.V., Creating A Top Five Global OTC Company 2Perrigo Company plc Completes Acquisition Of Omega Pharma Invest N.V., Creating A Top Five Global OTC Company 3Perrigo Company plc Completes Acquisition Of Omega Pharma Invest N.V., Creating A Top Five Global OTC Company 4Perrigo Company plc Completes Acquisition Of Omega Pharma Invest N.V., Creating A Top Five Global OTC Company 5MedAptus Launches Automated Patient Assignment Solution for Hospitalists, Other Rounding Specialists 2MedAptus Launches Automated Patient Assignment Solution for Hospitalists, Other Rounding Specialists 3Edison Nation Medical Announces Open Innovation Search Focused on Senior Mobility Products 2Edison Nation Medical Announces Open Innovation Search Focused on Senior Mobility Products 3
... December 6, 2011 Biospace Lab and the ... collaborating on the development of a new X-ray tomographic imaging ... a fully modular and versatile preclinical optical imager developed for ... new add-in module will be faster than current Micro CT ...
... 2011  Echo Therapeutics, Inc. (Nasdaq: ECTE ), ... non-invasive, wireless, transdermal continuous glucose monitoring (tCGM) system and ... announced a registered direct equity financing of approximately $5.4 ... one share of its common stock and a warrant ...
Cached Medicine Technology:Biospace Lab Collaborates With ImaBio Group to Develop a Unique X-Ray Tomographic Module for its Preclinical Imaging System 2Echo Therapeutics Announces Pricing of $5.4 Million Registered Direct Equity Financing 2Echo Therapeutics Announces Pricing of $5.4 Million Registered Direct Equity Financing 3
Swedish Knee Cage -- hinged to track knee motion. Effective control of genu recurvatum (back knee or knee hyperextension). Fits left or right....
... in the Cryo/Cuff line, the Knee Cryo/Cuff ... filled directly with water and ice eliminating ... the optimal amount of compression, a hand ... application. The cuff remains cold for about ...
... shoulder immobilization and ... motion for glenohumeral ... tears, and acromioclavicular ... brace is designed ...
... Bird and Cronin, Inc. ... of Patient Footwear, Orthopedic ... Care Products. Our products ... quality and available in ...
Medicine Products: