Navigation Links
Epilepsy-induced brain cell damage prevented in the laboratory
Date:10/29/2007

St. Louis, October 29, 2007 — For some epilepsy patients, the side effects of epilepsy can be as troubling as the seizures. One pressing concern is the cognitive impairment seizures often inflict, which potentially includes memory loss, slowed reactions and reduced attention spans.

Now scientists at Washington University School of Medicine in St. Louis have directly observed seizure-induced structural changes in brain cells in laboratory animals. They report in The Journal of Neuroscience that the insights they gained allowed them to use a drug to block those changes in the brain.

"Assuming that these structural changes are linked to cognitive impairment -- and there's a lot of data to suggest that's true – then this could provide us with a path to therapies that reduce cognitive problems in epilepsy," says senior author Michael Wong, M.D., Ph.D., assistant professor of neurology, of anatomy and neurobiology, and of pediatrics.

Approximately 1 to 2 percent of the general population suffers from some form of epilepsy. Severe or prolonged seizures can cause brain cell death, leading to anatomic damage visible on brain scans. But in some cases the cognitive impairments caused by seizures cannot be linked to discernible brain damage.

Prior studies have suggested that seizures may damage dendrites, treelike branches that extend from a nerve cell to receive signals. In studies of human tissue, researchers noted the loss of spines, small bumps on the exterior of the dendrite. Spines are known to be important for the formation of synapses, junctions where two nerve cells communicate across a small gap.

"Previous studies were helpful in suggesting that dendrite structure was being damaged, but they couldn't prove cause-and-effect and provided only limited information on the timing and mechanisms of the processes that led to damage," says Wong.

Led by postdoctoral fellows Ling-hui Zeng, M.D., Ph.D. and Lin Xu, Ph.D.,
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Brain death – How to cope with it
3. Multi billion-dollar suit filed against cell phone firm for causing brain tumours
4. “Brain fingerprinting”- The new lie detectr
5. Nasal Spray Could Take Drugs Direct to Brain.
6. Two doctors suspended for wrong brain surgery
7. The brain loves a surprise
8. Virus Combats Brain Tumour
9. Increase in sugar...decrease in brain function!!!
10. Alcohol shrinks brain
11. Roller coaster takes brain for a big ride!!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... (PRWEB) April 17, 2015 Scientists ... a multicenter team of U.S. and Venezuelan researchers, ... yet in humans among an isolated tribe of ... Venezuela. Bacterial diversity in the Yanomami, previously unexposed ... be nearly double that of people living in ...
(Date:4/17/2015)... Calvary Hospital recently announced Timothy P. Barr will be ... May 11. The Fund directs all fundraising efforts in support ... J. Spinelli, who retired several months ago. , “We are ... the important work that the Fund does every year,” said ... expand and bring our signature care to people who need ...
(Date:4/17/2015)... NJ (PRWEB) April 17, 2015 ... in the posterior pituitary and thought to help mothers ... between couples. To further substantiate this, new studies performed, ... the journal, Nature, and reported by Medical News Today ... a powerful influence over maternal social behavior. The study ...
(Date:4/17/2015)... New York, NY (PRWEB) April 17, 2015 ... is formulated to polish and perfect facial ... Ecuadorian Ivory Palm seeds and blend of energizing ... dulling dead skin cells that cause breakouts and ... , Star Ingredients: , Ecuadorian Ivory Palm Seeds, ...
(Date:4/17/2015)... 17, 2015 According to the ... 50 million Americans suffer from all types of allergies, ... eye allergies. Thanks to comprehensive allergy testing that’s being ... ), there’s now a way to get recommended treatment ... “Allergy triggers, or allergens, can vary by region of ...
Breaking Medicine News(10 mins):Health News:Mount Sinai Scientists Find Unprecedented Microbial Diversity in Isolated Amazonian Tribe Previously Unexposed to Antibiotics or Processed Foods 2Health News:Mount Sinai Scientists Find Unprecedented Microbial Diversity in Isolated Amazonian Tribe Previously Unexposed to Antibiotics or Processed Foods 3Health News:Timothy P. Barr Appointed Executive Vice President of Calvary Fund 2Health News:Timothy P. Barr Appointed Executive Vice President of Calvary Fund 3Health News:Oxytocin Now Found to Help Diet Doc Patients Whose Weight Has Gotten out of Control Due to Emotional Eating Disorders 2Health News:Oxytocin Now Found to Help Diet Doc Patients Whose Weight Has Gotten out of Control Due to Emotional Eating Disorders 3Health News:Mario Badescu Skin Care Launches Botanical Exfoliating Scrub 2Health News:CareMed Urgent & Primary Care Now Offering Comprehensive Allergy Testing 2Health News:CareMed Urgent & Primary Care Now Offering Comprehensive Allergy Testing 3
... New England Journal of Medicine suggested that moderate drinking ... individuals. The study was conducted over a 12-year period ... osteopathic physicians and podiatrists, aged 40 to 75 years. ... frequency of drinking. ,The study showed that it ...
... A study which appeared in the clinical journal ... associated with a five-year risk of ocular hypertension, ... prevalence// of glaucoma, in Caucasians. The study was ... to 84, who received baseline assessments of refractive ...
... Cancer and Leukemia Group B (CALGB) and presented at ... the effectiveness of reducing the interval between successive doses ... rates in breast cancer// women. This study was conducted ... in the 1980s that suggested the value of increased ...
... cancer has been associated to many risk factors like ... consumption. Several earlier studies have linked alcohol to breast ... because smoking often accompanies drinking, researchers have not been ... ,Now, researchers from Cancer Research, UK, who included dozens ...
... American Medical Association published a recent comparative study done ... results from a telephone survey of people living in ... who were asked to name up to three stroke ... a similar survey conducted in 1995 to study the ...
... a recent study have found that people who take ... higher risk of developing gastrointestinal bleeding. The study which ... anti-depressant// users, who were compared for hospitalizations due to ... ,Researchers found people on selective serotonin reuptake inhibitors, or ...
Cached Medicine News:Health News:Survival rates in breast cancer patients improved with "Dose Dense Chemotherapy" 2
(Date:4/17/2015)... Inivata, a Cambridge, England ... presence at the 2015 American Association for Cancer Research (AACR) ... Nitzan Rosenfeld and a poster presentation. Michael Stocum ... - 22 nd . The presentation, entitled ... forms part of a session on Recent Advances ...
(Date:4/17/2015)... Research and Markets ( http://www.researchandmarkets.com/research/dl9gbg/admetoxicology ) ... - Global Strategic Business Report" report to their ... for ADME-Toxicology Testing in US$ Million by the following ... The report provides separate comprehensive analytics for ... Japan , Europe , ...
(Date:4/17/2015)... Research and Markets ( http://www.researchandmarkets.com/research/vrd3bd/mammography ) ... - Global Strategic Business Report" report to their ... for Mammography Equipment in US$ Thousands by the following ... The report provides separate comprehensive analytics for the US, ... , Europe , Asia-Pacific ...
Breaking Medicine Technology:Inivata Co-founder Nitzan Rosenfeld to Present at AACR Annual Meeting 2ADME-Toxicology Testing (In-Vivo, & In-Vitro) Market - Global Strategic Business Report 2015: Pharma Industry Renews Focus on Cost Optimization 2Mammography Equipment (Analog & Digital) Market 2015-2020 - Global Strategic Business Report: Breast Imaging Screening Programs Push Sales 2
... THE WOODLANDS, Texas, Feb. 16, 2012   Lexicon Pharmaceuticals, ... company focused on discovering breakthrough treatments for human disease, ... financial results on Wednesday, February 22, 2012 before the ... call and webcast to discuss clinical development progress and ...
... 16, 2012  2WIN! Global,s Bob Riefstahl will deliver the ... Diagnostic Sales Training and Development Conference in Phoenix next ... hearing it again and again from your sales and ... 2WIN! Global CEO and Founder, Bob Riefstahl. "For over ...
Cached Medicine Technology:Lexicon to Report Fourth Quarter and Year End 2011 Financial Results on February 22, 2012 22WIN! ® Global Keynotes at Upcoming Medical Device Conference: 2
The Unistik 3 family of single use safety lancets has 4 models for use across all clinical environments....
The Stat-Let lines of disposable lancets are all designed with the goals of providing a safe and easy to achieve capillary blood sampling. All of our lancets can be used by most current models of lan...
The BD Ultra-Fine 33 Lancets are the thinnest lancets available, which means that you'll experience less pain when taking a blood sample....
... flow and minimize pain when performing ... BD Microtainer Quikheel Lancet. The simple ... providing a precise and consistent incision, ... its casing, helping to protect you ...
Medicine Products: