Navigation Links
Epilepsy-induced brain cell damage prevented in the laboratory
Date:10/29/2007

St. Louis, October 29, 2007 — For some epilepsy patients, the side effects of epilepsy can be as troubling as the seizures. One pressing concern is the cognitive impairment seizures often inflict, which potentially includes memory loss, slowed reactions and reduced attention spans.

Now scientists at Washington University School of Medicine in St. Louis have directly observed seizure-induced structural changes in brain cells in laboratory animals. They report in The Journal of Neuroscience that the insights they gained allowed them to use a drug to block those changes in the brain.

"Assuming that these structural changes are linked to cognitive impairment -- and there's a lot of data to suggest that's true – then this could provide us with a path to therapies that reduce cognitive problems in epilepsy," says senior author Michael Wong, M.D., Ph.D., assistant professor of neurology, of anatomy and neurobiology, and of pediatrics.

Approximately 1 to 2 percent of the general population suffers from some form of epilepsy. Severe or prolonged seizures can cause brain cell death, leading to anatomic damage visible on brain scans. But in some cases the cognitive impairments caused by seizures cannot be linked to discernible brain damage.

Prior studies have suggested that seizures may damage dendrites, treelike branches that extend from a nerve cell to receive signals. In studies of human tissue, researchers noted the loss of spines, small bumps on the exterior of the dendrite. Spines are known to be important for the formation of synapses, junctions where two nerve cells communicate across a small gap.

"Previous studies were helpful in suggesting that dendrite structure was being damaged, but they couldn't prove cause-and-effect and provided only limited information on the timing and mechanisms of the processes that led to damage," says Wong.

Led by postdoctoral fellows Ling-hui Zeng, M.D., Ph.D. and Lin Xu, Ph.D.,
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Brain death – How to cope with it
3. Multi billion-dollar suit filed against cell phone firm for causing brain tumours
4. “Brain fingerprinting”- The new lie detectr
5. Nasal Spray Could Take Drugs Direct to Brain.
6. Two doctors suspended for wrong brain surgery
7. The brain loves a surprise
8. Virus Combats Brain Tumour
9. Increase in sugar...decrease in brain function!!!
10. Alcohol shrinks brain
11. Roller coaster takes brain for a big ride!!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2015)... (PRWEB) March 28, 2015 Healthpointe’s otolaryngologists, ... nose and throat disorders, are now offering a ... common issue which is characterized by the presence of ... in 5 people, tinnitus is a prevalent symptom that ... while it is non-fatal, tinnitus can impede a person’s ...
(Date:3/28/2015)... ARDX will sponsor the 7th Annual Women’s Wellness Celebration on ... Center in Chesapeake, Virginia. Each year, ARDX celebrates Women’s ... the Hampton Roads region. The 2015 Women’s History Month ... grow stronger through sharing their stories and learning the strategies ... theme is T-talk where we will share a cup of ...
(Date:3/28/2015)... LTW Cyber is an innovation hub for technology ... of addressing the needs of the global market for ... to grow while seeking collaborative opportunities with the other ... in LTW Cyber focus on secure application security, grounded ... and analyzing open source. As the hub matures, ...
(Date:3/27/2015)... March 27, 2015 In her mid-forties and ... her from working, Monica K. arrived at JET Uniform ... department quiet, defensive and scared. The owners and staff at ... Services (EPSS) to offer jobs to challenged residents like ... and a willingness to begin with the end in mind,” ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 First Choice ... today. The new facility is located 12665 W Lake Houston ... a resident of Summerwood, I look forward to delivering the ... Dr. Sowell, Facility Medical Director of First Choice Emergency Room ... Emergency Room made a donation to Summer Creek High School ...
Breaking Medicine News(10 mins):Health News:Healthpointe now Offering Tinnitus Treatments in Clinics throughout Southern California 2Health News:Canadian Cybersecurity Ventures Globalize as a Collective 2Health News:Canadian Cybersecurity Ventures Globalize as a Collective 3Health News:Red Deer Uniforms Shop Celebrates 3rd Year Sewing Hope for the Challenged 2Health News:Red Deer Uniforms Shop Celebrates 3rd Year Sewing Hope for the Challenged 3Health News:First Choice Emergency Room Opens New Facility in Houston, Texas 2
... New Component Streamlines Safe ... ... PhaSeal System for the safe handling of hazardous drugs, now offers the Secondary Set (C60) for ... ease of use, the non-vented Secondary Set offers the following features:, , , ...
... Nov.1 issue of the journal Sleep shows that ... of sleep disturbances. Findings suggest that this general improvement in ... demands and stress rather than from actual health benefits of ... sleep in the seven years after retirement were 26 percent ...
... Previous studies have shown that hepatitis C virus ... Americans than in whites. However, researchers demonstrate in this ... of the American Association for the Study of Liver ... that recurrent HCV in the transplanted liver progresses faster ...
... at increased risk of deatheven compared to patients at ... research being presented at the American Society of Nephrology,s ... "Our study indicates that body fat may be ... at Harbor-UCLA). "The results add to the increasing number ...
... found that hepatitis B does not increase the risk for pancreatic ... The results contradict a previous study in 2008 that suggested ... B is an inflammation of the liver caused by a viral ... for the Study of Liver Diseases, Annual Meeting in Boston. ...
... House speaker Nancy Pelosi is scheduled to speak about ... growing coalition of community groups and healthcare partners that are ... can cause liver cancer and damage, or if untreated, death. ... & Toland is a part, promotes hepatitis B screening, vaccination ...
Cached Medicine News:Health News:Carmel Pharma Introduces PhaSeal Secondary Set (C60) 2Health News:Study shows that sleep disturbances improve after retirement 2Health News:African Americans Fare Worse After Undergoing Liver Transplantation Due to Hepatitis C 2Health News:African Americans Fare Worse After Undergoing Liver Transplantation Due to Hepatitis C 3Health News:For dialysis patients, skinny is dangerous 2Health News:Brown & Toland Supports Fight Against Hepatitis B 2
(Date:3/27/2015)... 27, 2015  Victoria Vein & Surgery Clinic is the ... Duality laser in Victoria, Texas . The ... as advanced laser treatments for a variety of medical and ... to provide more services for their patients. Since adding laser ... Victoria residents get rid of their unwanted ...
(Date:3/27/2015)... NEW YORK , March 27, 2015 A ... Latin America – Chile ... Peru are top targets for IVD firms.  The ... figures heavily into IVD strategies for the Latin American ... industry to support globally distributed supply operations. However, the country,s ...
(Date:3/27/2015)... 27, 2015 XRpro Sciences, Inc., a ... and development services which features high throughput transporter ... announced financial results for the year ended December ... Chairman of XRpro Sciences commented, "We have completed ... development stage to commercial stage in large part ...
Breaking Medicine Technology:Victoria Vein And Surgery Clinic Uses Advanced Astanza Duality Tattoo Removal Technology 2Kalorama: Beyond Brazil, Latin American IVD Market Grows 2Kalorama: Beyond Brazil, Latin American IVD Market Grows 3Kalorama: Beyond Brazil, Latin American IVD Market Grows 4XRpro Sciences Announces Fiscal 2014 Financial Results 2XRpro Sciences Announces Fiscal 2014 Financial Results 3XRpro Sciences Announces Fiscal 2014 Financial Results 4
... of USC,s ... Norris Cancer Center, ... pharmaceutical company dedicated to the discovery, rapid,development and commercialization of ... of a series of,presentations at the 2007 AACR-NCI-EORTC International Conference ...
... 24 PositiveFriends.com, (http://www.positivefriends.com ), a new online ... Diseases), today announced its official,launch into the online ... is the result of two years of R&D ... with HIV/AIDS, Hepatitis, Herpes, and,HPV (Human Papilloma Virus) ...
Cached Medicine Technology:SuperGen's Novel Hypomethylating Agent Highlighted at AACR Plenary Session 2SuperGen's Novel Hypomethylating Agent Highlighted at AACR Plenary Session 3PositiveFriends.com Launches STD Social Networking Site Balancing Dating with Online Support Features 2
... has created this extremely versatile and efficient ... liquid handling. With EDOS, high sample throughput ... with ease. ,The smallest volume that ... corresponding Combitip. The easy-to-follow user menus presented ...
... Dilutor-Dispenser is designed to transfer ... the clinical, biological, and chemical ... and performance as Gilsons other ... is ideal for routine laboratory ...
... synQUAD technology is a patented non-contact dispensing ... with a microsolenoid valve and stage stepper ... of liquid onto various slides, plates, or ... well, coefficient of variation (CVs) are less ...
16 channel Parallel dispenser using Positive Air Displacement Technology...
Medicine Products: