Navigation Links
Epilepsy Drugs' Risk of Birth Defects May Be Dose-Dependent
Date:6/6/2011

SUNDAY, June 5 (HealthDay News) -- Four of the most frequently prescribed epilepsy drugs appear to increase the risk of serious birth defects when taken early in pregnancy, a new study finds.

And the higher the dosage, the greater the risk, the international team of researchers reported in the June 6 online edition of The Lancet Neurology.

"Our results show that dose selection is as crucial as the choice of drug," the authors said in a journal news release. Their study gives doctors the opportunity to prescribe the safest anti-seizure medication at the safest level for women with epilepsy who want to get pregnant, they said.

The drugs studied were carbamazepine (Tegretol, Epitol), lamotrigine (Lamictal), valproic acid (Depakote), and phenobarbital.

The rate of birth defects was higher with increased dose for all the drugs, the researchers said, but they emphasized that the vast majority of women in their study delivered healthy children.

Most women with epilepsy need to take anti-seizure medication or risk harming themselves or their baby. Previous studies found that valproic acid, in particular, might increase the risk of birth defects, but those studies didn't look at individual doses. Nor did they take into account other influential factors, such as family history of birth defects or severity of epilepsy.

"Present guidelines caution on the use of valproic acid during pregnancy, but offer little guidance on alternative options and how to manage women whose seizures cannot be controlled by other drugs," Dr. Torbjorn Tomson, of the Karolinska Institute in Stockholm, Sweden, and colleagues, said in the news release.

For their 11-year study, the researchers used data from the International Registry of Antiepileptic Drugs and Pregnancy on nearly 4,000 pregnancies in 33 countries.

In all, 230 pregnancies resulted in major birth defects by the end of the first year after bi
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Oldest Epilepsy Drug Best for Children
2. New study identifies best treatment for childhood epilepsy
3. Implant Shows Promise for Hard-to-Treat Epilepsy
4. Purple Day March 26th: The United States Goes Purple in Support of Epilepsy Awareness
5. Fetal alcohol spectrum disorder linked to high prevalence of epilepsy, Queens study
6. Gene Mutation Ups Risk of Sudden Death in People with Epilepsy
7. Children with epilepsy say their quality of life is better than their parents think
8. University Hospitals Neurological Institute hosts international epilepsy colloquium
9. Altered brain development found in children with newly diagnosed epilepsy
10. Children With Epilepsy Feel on Par With Healthy Siblings
11. Study confirms favorable long-term prognosis of epilepsy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Epilepsy Drugs' Risk of Birth Defects May Be Dose-Dependent
(Date:9/3/2014)... Diego, CA (PRWEB) September 03, 2014 AttorneyOne.com, ... all the latest information from the FDA on Pedigree ... on August 26, that 22 bags of Pedigree Adult Complete ... to the possible presence of a foreign material. The reason ... metal fragments, which could have entered the packages during the ...
(Date:9/3/2014)... While the Affordable Care Act provides ... the goal of offering better quality care at ... increasing scrutiny of hospital-physician transactions to ensure they ... This increased scrutiny resulted in the first-ever antitrust ... physician practice earlier this year. , ...
(Date:9/3/2014)... LabRoots announces a new educational webinar ... in Translational Diagnostics: Mining and Migrating Robust Cancer ... be airing live September 10, 2014 1:00pm Eastern Time. ... NGS-based biomarker discovery will be introduced, as ... these markers to targeted NGS assays using low-quality (FFPE) ...
(Date:9/3/2014)... (PRWEB) September 03, 2014 Health ... increases patient safety, decreases medical errors, and strengthens ... , To mark the important role health information ... IHS and others across the U.S. have joined ... Week , September 16-20, 2014. With the NHIT ...
(Date:9/3/2014)... 03, 2014 Job seekers who are ... next position can now do both on iHire. By ... a seamless tool for investigating employment and educational opportunities ... online courses) are closing skills gaps and challenging the ... degree programs and brick and mortar universities. To make ...
Breaking Medicine News(10 mins):Health News:Pedigree Adult Complete Nutrition for Dogs Recalled: AttorneyOne Monitors and Keeps Consumers Informed 2Health News:Recent Becker’s Article Addresses Antitrust and Hospital Acquisition of Physician Practices 2Health News:LabRoots Announces New Educational Webinar on Next-Generation Sequencing 2Health News:LabRoots Announces New Educational Webinar on Next-Generation Sequencing 3Health News:Innovative Healthcare Solutions (IHS) Celebrates National Health IT Week September, 15-19, 2014 2Health News:iHire Announces Partnership with MOOCtracks 2
... Clinical Oncology (ASCO) today highlighted several studies in a ... posted online at www.asco.org in advance of ASCO,s 47th ... other major studies will be released in on-site press ... meeting, which is expected to draw approximately 30,000 cancer ...
... receives the Green Mark Platinum Award from the Building ... environmental sustainability. The highest award presented to selected organisations ... towards sustainability. The award goes to NTU,s School ... piece in the centre of the 200-hectare green campus ...
... , WEDNESDAY, May 18 (HealthDay News) -- New research finds ... cancer don,t reduce the average woman,s risk of dying from ... then a transvaginal ultrasound might even cause harm, the University ... of worrisome false-positive results, subsequent biopsies and resulting complications. ...
... of Pittsburgh School of Medicine have developed a mouse model ... rare genetic mutation that appears to cause MDD in the ... published online today in the American Journal of Medical ... clarify the brain events that lead to MDD, and contribute ...
... Reporter , WEDNESDAY, May 18 (HealthDay News) -- The ... the progression of eye problems in people with the ... says. Italian researchers report that they compared daily ... a placebo, and found that selenium could benefit people ...
... 18 (HealthDay News) -- The results of a first prostate-specific antigen ... can predict the risk of dying of prostate cancer within the ... Researchers analyzed blood samples collected from 12,090 Swedish men between 1974 ... nearly 5,000 of the men six years later when they were ...
Cached Medicine News:Health News:ASCO releases studies from upcoming annual meeting 2Health News:ASCO releases studies from upcoming annual meeting 3Health News:NTU wins Platinum Award from BCA for sustainable design 2Health News:Study Finds Ovarian Screening Tests Don't Improve Survival 2Health News:Pitt researchers build a better mouse model to study depression 2Health News:Selenium Might Help Treat Symptoms in Graves' Eye Disease 2Health News:Selenium Might Help Treat Symptoms in Graves' Eye Disease 3Health News:Earlier PSA Test Best Predicts Risk of Dying From Prostate Cancer: Study 2
(Date:9/3/2014)... ,    ... ~   Kiadis Pharma B.V. ... biopharmaceutical company developing T-cell immunotherapy treatments for blood cancers, ... , MD PhD, as its Chief Medical Officer. ... at Ceronco Biosciences. Prior to that he was VP ...
(Date:9/2/2014)... 2014 Reportbuyer.com has added a new ... Technologies for Molecular Imaging Devices ... The objectives of this study are to ... used for diagnostic purposes, present global market measurements ... market segments as well as forecast market and ...
(Date:9/2/2014)... -- Numotion is pleased to announce the appointment of Mark ... Mark is a 30-year retired veteran of GE where ... and was a GE Company Officer since 1999 and a ... running business units within GE Healthcare, with the most recent ... "We are delighted to welcome Mark to our Board," ...
Breaking Medicine Technology:Kiadis Pharma Appoints Jeroen Rovers as its Chief Medical Officer 2Kiadis Pharma Appoints Jeroen Rovers as its Chief Medical Officer 3Kiadis Pharma Appoints Jeroen Rovers as its Chief Medical Officer 4Kiadis Pharma Appoints Jeroen Rovers as its Chief Medical Officer 5Global Markets and Technologies for Molecular Imaging Devices 2Global Markets and Technologies for Molecular Imaging Devices 3Global Markets and Technologies for Molecular Imaging Devices 4Global Markets and Technologies for Molecular Imaging Devices 5Global Markets and Technologies for Molecular Imaging Devices 6Global Markets and Technologies for Molecular Imaging Devices 7Global Markets and Technologies for Molecular Imaging Devices 8Global Markets and Technologies for Molecular Imaging Devices 9Global Markets and Technologies for Molecular Imaging Devices 10Global Markets and Technologies for Molecular Imaging Devices 11Global Markets and Technologies for Molecular Imaging Devices 12Global Markets and Technologies for Molecular Imaging Devices 13Global Markets and Technologies for Molecular Imaging Devices 14Global Markets and Technologies for Molecular Imaging Devices 15Global Markets and Technologies for Molecular Imaging Devices 16Global Markets and Technologies for Molecular Imaging Devices 17Global Markets and Technologies for Molecular Imaging Devices 18Global Markets and Technologies for Molecular Imaging Devices 19Global Markets and Technologies for Molecular Imaging Devices 20Global Markets and Technologies for Molecular Imaging Devices 21Global Markets and Technologies for Molecular Imaging Devices 22Global Markets and Technologies for Molecular Imaging Devices 23Global Markets and Technologies for Molecular Imaging Devices 24Global Markets and Technologies for Molecular Imaging Devices 25
... Tenn., Nov. 18, 2011 MedSolutions , ... services, today announced the launch of its Implantable ... evidence-based guidelines to ensure the clinical appropriateness of ... With the cost of each ICD/CRT-D ...
... Md., Nov. 18, 2011 The U.S. Food and ... ) to treat patients with acute lymphoblastic leukemia (ALL), ... coli derived asparaginase and pegaspargase chemotherapy drugs used ... ) Acute lymphoblastic leukemia is a ...
Cached Medicine Technology:MedSolutions Launches Implantable Cardiac Defibrillator Program to Reduce Unnecessary Surgeries 2MedSolutions Launches Implantable Cardiac Defibrillator Program to Reduce Unnecessary Surgeries 3FDA Approves Erwinaze to Treat a Form of Leukemia 2FDA Approves Erwinaze to Treat a Form of Leukemia 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: