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Epilepsy Drugs Can Cause Suicidal Tendencies, FDA Panel Finds
Date:7/10/2008

Backs agency review of 11 anti-seizure drugs that showed double the risk

THURSDAY, July 10 (HealthDay News) -- Anti-seizure drugs can cause increased suicidal tendencies in patients, a U.S. health advisory panel concluded Thursday.

The 20-member panel of experts voted unanimously to back the findings on 11 antiepileptic drugs studied by the U.S. Food and Drug Administration, the Associated Press reported.

In late January, the FDA announced an agency review of 199 studies comparing the drugs, which are used by millions, to placebos. That review found that patients taking the drugs had about twice the risk of suicidal behavior compared with patients taking a placebo. In fact, of the almost 44,000 patients in the studies, four people taking antiepileptic drugs committed suicide while none of the patients receiving a placebo did.

"We have been looking at these drugs since 2005," FDA spokeswoman Sandy Walsh said at the time. "We have just come to the conclusion that it's time to alert health-care providers."

The drugs under review were: Carbamazepine (marketed as Carbatrol, Equetro, Tegretol, Tegretol XR), Felbamate (marketed as Felbatol), Gabapentin (marketed as Neurontin), Lamotrigine (marketed as Lamictal), Levetiracetam (marketed as Keppra), Oxcarbazepine (marketed as Trileptal), Pregabalin (marketed as Lyrica), Tiagabine (marketed as Gabitril), Topiramate (marketed as Topamax), Valproate (marketed as Depakote, Depakote ER, Depakene, Depacon) and Zonisamide (marketed as Zonegran). Some of these drugs are also available as generics.

According to the FDA, antiepileptic drugs are used to treat epilepsy, bipolar disorder, migraine headaches and other conditions.

As of now, the FDA is advising patients not to make any changes in their medication without talking to their doctor, Walsh said in January. "Caregivers should pay close attention to changes in mood, behavior and actions," s
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