Navigation Links
Epilepsy Drug May Boost Birth Defect Risk
Date:7/21/2008

Women who take topiramate should discuss preconception planning with their doctor

MONDAY, July 21 (HealthDay News) -- Pregnant women who use the epilepsy drug topiramate alone or in combination with other epilepsy drugs may be increasing their risk of birth defects, British researchers report.

Topiramate (brand name Topamax) is a common anti-seizure medication used by many with epilepsy. It's also used to treat migraine headaches. Many similar drugs also increase the risk of birth defects, but until this report, the link between birth defects and topiramate had not been well studied.

"More research needs to be done to confirm these results, especially since it was a small study," lead researcher John Craig, of the Royal Group of Hospitals in Belfast, Northern Ireland, said in a news release from the American Academy of Neurology. "But these results should also get the attention of women with migraine and their doctors, since topiramate is also used for preventing migraine, which is an even more common condition that also occurs frequently in women of childbearing age."

The report is published in the July 22 issue of the journal Neurology.

For the study, the researchers collected data on women who became pregnant while taking topiramate alone or in combination with other epilepsy drugs.

Craig's team found that of the 178 babies born, 16 (4.8 percent) suffered from major birth defects. Among the babies with birth defects, three of the mothers were taking topiramate exclusively, while 13 were taking topiramate plus other epilepsy drugs.

Four of the babies had cleft palettes or cleft lips. That's a rate 11 times higher than one would expect among women not taking the drug, the researchers said.

Among male babies, four had genital defects, with two classified as "major defects." That's a rate 14 times higher than normal, the researchers reported.

The incidence of birth defects among women taking topiramate was higher than the rate of birth defects in the general population, which is about 1 percent to 2.5 percent. And there were more birth defects among women taking topiramate along with the epilepsy drug valproate, compared with women taking topiramate and another epilepsy drug.

Despite the risk, it's important that women maintain effective epilepsy control during pregnancy, because seizures can also harm the fetus. The risk of birth defects may be different among women taking topiramate to treat migraines, but these women should be monitored as well, the researchers said.

Dr. Orrin Devinsky, a professor of neurology, neurosurgery and psychiatry, and director of the New York University Epilepsy Center, said this study underscores the need for all women of childbearing years who take antiepileptic drugs to discuss preconception planning with their physician.

"All women should clearly understand the risks and benefits of their therapy," Devinsky said. "Until more information is available, topiramate use in women who plan on conceiving should be restricted to those in whom the drug is definitely needed for seizure control or other indications. Also, the mother should be informed of the potential risks to her child."

Another epilepsy expert, Dr. Edward Barry Bromfield, chief of the Division of Epilepsy at Brigham and Women's Hospital in Boston, agreed that women should be warned about the potential side effects of the drug.

"Women with epilepsy, if they depend on this drug to control their convulsive seizures, they should definitely continue it," Bromfield said. "If they are taking it for migraine prevention, chances are they would want to discontinue it before conception," he said.

More information

For more on epilepsy, visit the U.S. National Library of Medicine.



SOURCES: Orrin Devinsky, M.D., professor of neurology, neurosurgery and psychiatry, and director, New York University Epilepsy Center, New York City; Edward Barry Bromfield, M.D., chief, Division of Epilepsy, Brigham and Women's Hospital, Boston; July 22, 2008, Neurology


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Some Epilepsy Patients Are Good Candidates for Surgery
2. Ovation further advances development pipeline with new phase III epilepsy study
3. A childs IQ could be affected by maternal epilepsy
4. Research shows how genetic mutation causes epilepsy in infants
5. Epilepsy Drug Holds Promise as Treatment for Alcoholism
6. Lamotrigine May Reduce Epilepsy Seizures
7. Childhood epilepsy research offers new hope for seizure control
8. Epilepsy drugs may cause sexual disorders
9. Quality of life study examines burden of epilepsy
10. Epilepsy-induced brain cell damage prevented in the laboratory
11. Epilepsy genes may cancel each other
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... , ... February 08, 2016 , ... ... L top-load case packer for pouches, bags, and flow wrapped products at WestPack ... co-packers and specialty product manufacturers step up to semi-automatic or fully-automatic case packing ...
(Date:2/8/2016)... Venice, FL (PRWEB) , ... February 08, 2016 ... ... their new community enrichment program serving the greater Venice, FL area, has initiated ... died tragically in a car accident just four days after Christmas. To support ...
(Date:2/8/2016)... ... February 08, 2016 , ... FileHold's document management ... DocuSyst provides a cloud hosted environment for FileHold software that is pay per ... 3rd party applications using the FileHold web services API. DocuSyst also advises clients ...
(Date:2/8/2016)... ... February 08, 2016 , ... Joshua Rosenthal, PhD, Chief Scientific ... can use newly released government data on populations and physicians to better calculate ... capture the value they create to succeed in new economic models for value ...
(Date:2/7/2016)... Orion, Clarkston, Metamora, Michigan (PRWEB) , ... February 07, 2016 , ... ... Friday in recognition of National Wear Red Day. National Wear Red Day is ... and stroke in women. Heart disease and stroke cause 1 in 3 deaths among ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 8, 2016 Vestagen Technical Textiles, Inc., a ... for healthcare and other demanding applications, today announced it ... He replaces Dale Pfost , PhD, who was ... is also joining Vestagen,s Board of Directors. ... active barrier technologies that combines fluid repellent, antimicrobial and ...
(Date:2/8/2016)... , Feb. 8, 2016  Unilife Corporation ("Unilife" or ... supplier of injectable drug delivery systems, today announced that it ... months ended December 31, 2015 after market close on February ... a conference call to discuss these financial results.    ... Corporation --> About Unilife Corporation ...
(Date:2/8/2016)... 8, 2016  Astellas Pharma Inc. President and Chief Executive ... James Robinson as president, Americas Operations, for Astellas ... and South America , effective April 1, ... the commercial organization in the United States ... Masao Yoshida , who is retiring in June 2016.  ...
Breaking Medicine Technology: