Navigation Links
Epilepsy Drug Doesn't Prevent Migraines
Date:2/11/2008

Unlike other epilepsy meds, Trileptal was no better than placebo, study finds

MONDAY, Feb. 11 (HealthDay News) -- The epilepsy drug oxcarbazepine (Trileptal) does not seem to prevent migraines, as once thought, a new study finds.

Migraines affect more than 28 million Americans, and certain epilepsy drugs have been shown to be effective in preventing these severe headaches. For this reason, many assumed that oxcarbazepine would also work against migraines.

However, "the results of this trial do not support preliminary data which had suggested oxcarbazepine was effective in preventing migraine," lead researcher Dr. Stephen D. Silberstein, from Thomas Jefferson University in Philadelphia, said in a statement. "While several epilepsy drugs have been used for decades to prevent migraine, oxcarbazepine did not prevent migraine in this study despite it being shown to be safe and well-tolerated."

In the trial, 170 men and women took oxcarbazepine or placebo daily for almost five months. All the people in the study suffered from three to nine migraine attacks a month. Silberstein's team found no difference between people taking oxcarbazepine or placebo in the number of migraines they suffered during the study.

The report appears in the Feb. 12 issue of Neurology.

"It's good to do these types of double-blind studies to assess effectiveness of medications," said Dr. Walter J. Molofsky, chairman of the Department of Neurology at Beth Israel Medical Center in New York City.

"Since some antiepileptics are useful against migraine headaches, it would be reasonable to assume that Trileptal would work, too. This is an example of what is necessary to prove the presence or absence of benefit," Molofsky said.

The three epilepsy drugs that have been shown to prevent migraines, topiramate, divalproex and gabapentin, do so through several mechanisms. One mechanism is the regulation of the neurotransmitter called GABA. However, oxcarbazepine appears not to affect GABA activity. It is possible that epilepsy drugs need to regulate GABA to prevent migraine, Silberstein noted.

Another expert agreed that this drug is not likely to prevent migraine.

"This is a study done by a group of experts in the field following all the usual standards of clinical research, so the findings can be accepted as valid," said Dr. Ellen Drexler, director of the Headache Center at Maimonides Medical Center in New York City. "The results are not that surprising, as drugs with related mechanisms of action such as carbamazepine or phenytoin have never been found to be efficacious for migraine prophylaxis."

The study was paid for by Novartis Pharmaceuticals Corp., maker of oxcarbazepine. Just last week , the U.S. Food and Drug Administration warned that 11 epilepsy drugs, including oxcarbazepine, might boost the risk of suicide among users.

More information

For more information on migraines, visit the U.S. National Library of Medicine.



SOURCES: Ellen Drexler, M.D., director, Headache Center, Maimonides Medical Center, New York City; Walter J. Molofsky, M.D., chairman, department of neurology, Beth Israel Medical Center, New York City; Feb. 12, 2008, Neurology


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. FDA Warns Epilepsy Drugs May Raise Suicide Risk
2. Former Sufferer of Rare Disease Called Musicogenic Epilepsy Thanks LIJ Medical Team That Ended Her Seizures and Gave Her Back the Gift of Music
3. Former NFL Star Tiki Barber and CURE Founder Susan Axelrod Speak Out About Epilepsy on TODAY Show
4. Yale Neurosurgeon Named American Epilepsy Society President
5. UCB Announces Positive Results From Phase II Clinical Trial of Investigational Anti-Epilepsy Drug Brivaracetam
6. Leading Epilepsy Groups Unveil New Survey Results Challenging Patients to Take Charge of Their Health
7. Tracking Drug Levels Helps Pregnant Women With Epilepsy
8. UCB Announces FDA Filing for lacosamide in the Treatment of Partial Onset Seizures in Adults with Epilepsy
9. Some Epilepsy Patients Not Always Aware of Seizures
10. Epilepsy.com Wins Silver for Best Patient Care/Disease Management Website at the 2007 eHealthcare Leadership Awards - Honored at Healthcare Internet Conference in Las Vegas
11. Epilepsy genes may cancel each other
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Epilepsy Drug Doesn't Prevent Migraines
(Date:6/24/2016)... ... , ... Those who have experienced traumatic events may suffer from a complex ... as drug or alcohol abuse, as a coping mechanism. To avoid this pain and ... a traumatic event. , Trauma sufferers tend to feel a range of emotions, from ...
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Global law firm ... 2016 Legal Elite. The attorneys chosen by their peers for this recognition are considered ... Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are ... Code Talker Award, an essay contest in which patients and their families pay tribute ... presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 , ... Thursday, July 7, 2016 , , , , LOCATION: , ... , , , , EXPERT PANELISTS:  , , , Frost ... Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh ... The global pharmaceutical industry is witnessing an exceptional era. Several ...
(Date:6/23/2016)... , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with ... Latin America . ... ... ... ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: