Navigation Links
Epilepsy Drug Doesn't Prevent Migraines
Date:2/11/2008

Unlike other epilepsy meds, Trileptal was no better than placebo, study finds

MONDAY, Feb. 11 (HealthDay News) -- The epilepsy drug oxcarbazepine (Trileptal) does not seem to prevent migraines, as once thought, a new study finds.

Migraines affect more than 28 million Americans, and certain epilepsy drugs have been shown to be effective in preventing these severe headaches. For this reason, many assumed that oxcarbazepine would also work against migraines.

However, "the results of this trial do not support preliminary data which had suggested oxcarbazepine was effective in preventing migraine," lead researcher Dr. Stephen D. Silberstein, from Thomas Jefferson University in Philadelphia, said in a statement. "While several epilepsy drugs have been used for decades to prevent migraine, oxcarbazepine did not prevent migraine in this study despite it being shown to be safe and well-tolerated."

In the trial, 170 men and women took oxcarbazepine or placebo daily for almost five months. All the people in the study suffered from three to nine migraine attacks a month. Silberstein's team found no difference between people taking oxcarbazepine or placebo in the number of migraines they suffered during the study.

The report appears in the Feb. 12 issue of Neurology.

"It's good to do these types of double-blind studies to assess effectiveness of medications," said Dr. Walter J. Molofsky, chairman of the Department of Neurology at Beth Israel Medical Center in New York City.

"Since some antiepileptics are useful against migraine headaches, it would be reasonable to assume that Trileptal would work, too. This is an example of what is necessary to prove the presence or absence of benefit," Molofsky said.

The three epilepsy drugs that have been shown to prevent migraines, topiramate, divalproex and gabapentin, do so through several mechanisms. One mechanism is the regulation of the neurotransmitter called GABA. However, oxcarbazepine appears not to affect GABA activity. It is possible that epilepsy drugs need to regulate GABA to prevent migraine, Silberstein noted.

Another expert agreed that this drug is not likely to prevent migraine.

"This is a study done by a group of experts in the field following all the usual standards of clinical research, so the findings can be accepted as valid," said Dr. Ellen Drexler, director of the Headache Center at Maimonides Medical Center in New York City. "The results are not that surprising, as drugs with related mechanisms of action such as carbamazepine or phenytoin have never been found to be efficacious for migraine prophylaxis."

The study was paid for by Novartis Pharmaceuticals Corp., maker of oxcarbazepine. Just last week , the U.S. Food and Drug Administration warned that 11 epilepsy drugs, including oxcarbazepine, might boost the risk of suicide among users.

More information

For more information on migraines, visit the U.S. National Library of Medicine.



SOURCES: Ellen Drexler, M.D., director, Headache Center, Maimonides Medical Center, New York City; Walter J. Molofsky, M.D., chairman, department of neurology, Beth Israel Medical Center, New York City; Feb. 12, 2008, Neurology


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. FDA Warns Epilepsy Drugs May Raise Suicide Risk
2. Former Sufferer of Rare Disease Called Musicogenic Epilepsy Thanks LIJ Medical Team That Ended Her Seizures and Gave Her Back the Gift of Music
3. Former NFL Star Tiki Barber and CURE Founder Susan Axelrod Speak Out About Epilepsy on TODAY Show
4. Yale Neurosurgeon Named American Epilepsy Society President
5. UCB Announces Positive Results From Phase II Clinical Trial of Investigational Anti-Epilepsy Drug Brivaracetam
6. Leading Epilepsy Groups Unveil New Survey Results Challenging Patients to Take Charge of Their Health
7. Tracking Drug Levels Helps Pregnant Women With Epilepsy
8. UCB Announces FDA Filing for lacosamide in the Treatment of Partial Onset Seizures in Adults with Epilepsy
9. Some Epilepsy Patients Not Always Aware of Seizures
10. Epilepsy.com Wins Silver for Best Patient Care/Disease Management Website at the 2007 eHealthcare Leadership Awards - Honored at Healthcare Internet Conference in Las Vegas
11. Epilepsy genes may cancel each other
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Epilepsy Drug Doesn't Prevent Migraines
(Date:12/10/2016)... ... December 10, 2016 , ... ... vulnerable population in Syria’s civil war—babies and toddlers. , The situation in Syria ... are experiencing bombing, facing starvation, and dying from disease. The situation is intensifying ...
(Date:12/9/2016)... ... December 09, 2016 , ... Cellairis is a worldwide mobile device and ... iPhone , iPad and Samsung Galaxy devices with premium parts and accessories. ... to maximize convenience and accessibility for customers. While customers do their shopping, Cellairis can ...
(Date:12/9/2016)... ... December 09, 2016 , ... ... 10th anniversary with the grand opening of the Sober College Robert Pfeifer Memorial ... two days, December 2-3, and was attended by an overwhelming amount of alumni, ...
(Date:12/9/2016)... ... 2016 , ... MEDI+SIGN®, a provider of fully-automated patient monitoring ... for Emergency Departments (ED) has been added to their portfolio. Housed in a ... and with a simplified pallet of information available to the patient, the Digital ...
(Date:12/8/2016)... ... December 08, 2016 , ... The ... the Undersea and Hyperbaric Medical Society (UHMS), the leading authority in hyperbaric medicine. ... safety. Only a few hospitals and facilities have earned this distinction. This is ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... DUBLIN , Dec 8, 2016 Research ... Electrodes Market Analysis and Trends - Adhesion Type, Application, Usability - ... ... The Global Cardiology Electrodes Market is poised to grow at a ... prominent trends that the market is witnessing include advancements in extracellular ...
(Date:12/8/2016)... , Dec. 8, 2016  Pennsylvania Physician General ... Drug and Alcohol Programs Gary Tennis ... medications, known as benzodiazepines, developed with the help ... are medications that are frequently prescribed for anxiety ... are used with opioid pain medications, benzodiazepines pose ...
(Date:12/8/2016)... 2016  EIP Pharma, LLC ( www.eippharma.com ) ... neflamapimod (previously code named VX-745), with the results ... that demonstrated significant Alzheimer,s disease relevant pharmacological activity.  ... Study 303 (6-week treatment) are the subject of ... (CTAD) scientific conference in San Diego, ...
Breaking Medicine Technology: