Navigation Links
Epigenomic abnormalities predict patient survival in non-Hodgkins lymphoma
Date:1/10/2013

Think of the epigenome like a giant musical mixing board, turning up or down the expression of various genes. A University of Colorado Cancer Center study published today in the journal PLOS Genetics shows that in cancer, not only can genes themselves go bad, but abnormal changes in the epigenetic mixing board can unfortunately change the expression of these genes. Researchers hope to play the role of sound engineers, controlling these harmful epigenomic changes to turn down cancer itself or perhaps sensitize cancers to existing drugs.

The epigenome's primary tool and by far the easiest to study is methylation: it attaches little methyl groups to DNA sequences near the genes to silence or promote their expression.

"Not only do we see more abnormal methylation in non-Hodgkin lymphoma patients than in healthy B-cell populations, but there are three distinct subtypes of the disease in the clinic, each more aggressive than the next. These three clinical trajectories of non-Hodgkins lymphoma were distinctly marked by their levels of abnormal methylation," says Subhajyoti De, PhD, CU Cancer Center investigator and assistant professor at the CU School of Medicine.

In other words, methylation patterns predict patient survival. Here's how it works:

DNA should be methylated in a consistent way you get a certain, standardized amount of methyl "residue" attached to your genes. Sure enough, that's the case in healthy B-cells. Subhajyoti and colleagues show that in cancerous B-cells, the level of DNA methylation from cell to cell varies wildly. And the more wildly the level of DNA methylation varies, the more aggressive is the cancer. It's as if, in the body, you want a consistent epigenome that maintains the methylation of the healthy status quo when a willy-nilly epigenome drops methylation randomly here and there, it promotes non-normal cells, like cancer.

So abnormal methylation is certainly correlated with not onl
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Epilepsy Leads to More Brain Abnormalities Over Time
2. Insecticide Linked to Brain Abnormalities in Kids
3. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
4. Treatment of childhood OSA reverses brain abnormalities
5. Genome-wide analysis shows previously undetected abnormalities in parents of affected children
6. Gene Mutation Linked to Facial, Skull Abnormalities
7. Brain Scans of Hoarders Show Unique Abnormalities
8. Documenting womens experiences with chromosome abnormalities found in new prenatal test
9. Psychological testing may predict success in soccer
10. Predictors identified for rehospitalization among post-acute stroke patients
11. Can a standard vision test predict nighttime driving performance?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... With over 170,000 students now playing high school ... during practice and competition, according to a new study ... Center for Injury Research and Policy at Nationwide Children,s ... today by The American Journal of Sports Medicine ... injuries over the four academic years from 2008 through ...
(Date:7/22/2014)... 22, 2014 CareTouch Communications, Inc. has ... in the Community . CareTouch employees will select causes ... hands-on support in line with their mission to help ... The program’s first cause is Hike for Hospice, to ... On Sunday, September 14, the CareTouch in the Community ...
(Date:7/22/2014)... 22, 2014 A new and technologically ... laxity with results that are surprising even the most ... the skin with radio frequency, ThermiTight has been dubbed ... under the skin to “inject” heat to the tissues ... this single treatment solution for skin laxity produces results ...
(Date:7/21/2014)... one of the fastest-growing high school sports in the ... the sometimes hard-hitting game. The growing participation numbers, however, ... risk of injury in lacrosse practice and competition. , ... American Journal of Sports Medicine and available in ... Injury Research and Policy at Nationwide Children,s Hospital and ...
(Date:7/21/2014)... iFitDress.com, a famous company of wedding ... its exclusive collection of 2014 glitter evening dresses ... its brand new gowns. , iFitDress.com is one of ... Its sales boomed in the recent years, not just ... because of the amicable services offered on its website. ...
Breaking Medicine News(10 mins):Health News:High school lacrosse players at risk of concussions other injuries 2Health News:High school lacrosse players at risk of concussions other injuries 3Health News:CareTouch is a Peak Sponsor for the 9th Annual Hike for Hospice in Morrison, Colorado 2Health News:New Minimally Invasive Procedure, ThermiTight, “Injects” Radio Frequency to Treat Skin Laxity 2Health News:New study finds high school lacrosse players at risk for concussions, other injuries 2Health News:New study finds high school lacrosse players at risk for concussions, other injuries 3Health News:iFitDress.com: 2014 Glitter Evening Dresses For Worldwide Clients 2
... Change to Win Executive Director Greg Tarpinian on the ... to prevent employee,misclassification by New York Governor Eliot Spitzer:, ... unions with six million members,in the growth occupations and ... care, from construction and transportation to food,processing and hospitality ...
... program where small changes make a huge impact, ... as we celebrate the end of Healthy Steps, a ... Philadelphia Housing,Authority, and Philadelphia Safe and Sound on Friday, ... Community Center, 2500 Jackson Street in,South Philadelphia., The ...
... Kaiser Permanente has successfully,certified its greenhouse gas ... becoming the first health care organization to,earn the ... now,publicly and voluntarily reporting its 2006 GHG emissions ... paying attention to the organization,s impact on,the environment ...
... from the Centers for Disease Control and Prevention over ... in eight countries that lack the large-scale public health ... of the grant will support the efforts of Tulane ... of Ethiopia and rural Jimma University, to train ...
... Sept. 7 As states consider,proposals to expand ... assesses,the impact of prior efforts in states across ... launched "insurance reforms" with significant,unintended consequences. A number ... a few years of implementation. The study by,Milliman, ...
... N.C., Sept. 7 Pharmaceutical companies,face a unique ... and marketing forces, and quality production processes while ... The case studies in the,Multi-Year Compendium of Pharmaceutical ... were presented by industry leaders at Global,Benchmarking Council ...
Cached Medicine News:Health News:Tarpinian: Misclassification is Theft 2Health News:Tarpinian: Misclassification is Theft 3Health News:On September 7th Local Organizations Partner to Celebrate 'Healthy Steps' 2Health News:Kaiser Permanente Achieves Climate Action Leader Status 2Health News:Tulane University to receive $14M for international HIV/AIDS program 2Health News:New AHIP Report Takes a Ten Year Look at the Unintended Consequences of State Efforts to Change the Insurance Market 2Health News:Multi-Year Compendium of Pharmaceutical Case Studies Available from Best Practices, LLC 2
(Date:7/21/2014)... July 21, 2014 Galmed Pharmaceuticals Ltd. (Nasdaq: ... focused on the development and commercialization of a once-daily, ... cholesterol gallstones, announced today that it will host a ... to discuss results for the period ended June 30, ... with respect to its clinical program for aramchol. ...
(Date:7/21/2014)... Sorrento Therapeutics, Inc. (NASDAQ: SRNE ... treatments for cancer and its associated pain, today announced ... development of a small molecule inhibitor targeting the important ... protein has also been recognized as an important determinant ... as a dominant factor in most human cancers and ...
(Date:7/21/2014)... MARYVILLE, Ill. , July 21, 2014 /PRNewswire-iReach/ ... that Dr. Ryan Diederich has been ... on Membership and Advocacy for 2014-2015. This council ... member resources, services and benefits. The ... that represents and unifies its physician members as ...
Breaking Medicine Technology:Galmed Pharmaceuticals Second Quarter 2014 Conference Call and Webcast Scheduled for Friday, July 25, 2014 2Sorrento Awarded Grant from the National Institutes of Health for the Development of a Small Molecule Myc Inhibitor 2Sorrento Awarded Grant from the National Institutes of Health for the Development of a Small Molecule Myc Inhibitor 3Sorrento Awarded Grant from the National Institutes of Health for the Development of a Small Molecule Myc Inhibitor 4
... Dec. 21, 2011  VIVUS, Inc. (NASDAQ: VVUS ... retrospective study of medical claims data on oral ... utero .  The study, known as FORTRESS for ... mother-infant dyads exposed to topiramate either alone (monotherapy) ...
... Dec. 21, 2011 Despite the numerous medical advances ... the United States is still higher than most European ... the growing rate of pre-term births, researchers are committed ... Northwestern Medicine ® researchers are examining ...
Cached Medicine Technology:VIVUS Reports Topline Findings From FORTRESS 2VIVUS Reports Topline Findings From FORTRESS 3VIVUS Reports Topline Findings From FORTRESS 4VIVUS Reports Topline Findings From FORTRESS 5VIVUS Reports Topline Findings From FORTRESS 6Northwestern Researchers Trial New Device that May Support Improved Newborn Health 2Northwestern Researchers Trial New Device that May Support Improved Newborn Health 3Northwestern Researchers Trial New Device that May Support Improved Newborn Health 4
Each handle is designed to fit a specific trephine size....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Each handle is designed to fit a specific trephine size....
Each handle is designed to fit a specific trephine size....
Medicine Products: