Navigation Links
Epigenetic signals differ across alleles
Date:2/12/2010

Researchers from the Institute of Psychiatry (IoP), King's College London, have identified numerous novel regions of the genome where the chemical modifications involved in controlling gene expression are influenced by either genetic variation or the parental origin of that particular stretch of DNA. This contradicts previous assumptions that epigenetic signals are generally equal across both copies of a given region of the genome, except at a small number of known imprinted genes.

Sequencing the genome was only the first step in our quest to understand how genes are expressed and regulated. Epigenetics is the study of alterations to gene function, traditionally believed to occur independently of the DNA sequence. The epigenome sits above the DNA sequence and provides a second layer of information, regulating several genomic functions, including when and where genes are turned on or off. One of the best understood epigenetic mechanisms is DNA methylation, a chemical modification to DNA that can interfere with gene expression.

In the first quantitative genomic survey of allele-specific DNA methylation, published 11 Feburary 2010 in The American Journal of Human Genetics, scientists used sensitive high-throughput technology to detect evidence for skewed gene DNA methylation across both alleles - or copies - of the DNA sequence at almost 1 million positions in the genome.

Lead researcher Dr Jonathan Mill, Medical Research Council Social Genetic, Developmental and Psychiatry Centre at the IoP said: "Interestingly, we found numerous examples where DNA methylation was not equal across alleles - in some instances this depended upon genotype, and in other cases it depended upon which parent that allele was inherited from.

He continues: "Our data show that allele-specific DNA methylation is a widespread phenomenon with potentially over 35,000 such sites occurring across the genome. It appears that a spectrum of skewing is likely, differing between individuals and across tissues.

Dr Mill concludes: "These findings impact upon our understanding about the origin of biological variation and have implications for genetic studies of complex disease including most psychiatric conditions. Because DNA methylation can also be influenced by various environmental factors, the variation we have uncovered provides a potential substrate for interactions between nature and nurture."


'/>"/>

Contact: Erin Seymour
erin.seymour@kcl.ac.uk
44-207-848-5377
King's College London
Source:Eurekalert

Related medicine news :

1. Discovery of epigenetic memory during breast cancer
2. Johns Hopkins epigenetic center receives $16.8 million NIH grant
3. BioInformatics, LLC New Report - Exploring the Epigenetics Market: Opportunities for Product Placement and Innovations
4. Proteasome inhibition affects epigenetic mechanisms
5. Tackling a hard-to-treat childhood cancer by targeting epigenetic changes
6. Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes
7. First evidence that prenatal exposure to famine may lead to persistent epigenetic changes
8. New revelations in epigenetic control shed light on breast cancer
9. Senator Landrieu Closes Office: Constituents Turned Away at the Door, Callers Reach Only Busy Signals
10. New AERIUS Cell Phones Direct Microwave Signals Away from Users
11. Perceptual learning relies on local motion signals to learn global motion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun ... NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is ... is geared towards children of all ages; it is a non-competitive, non-timed event, which ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance ... management, will showcase a range of technology and learning solutions at the 68th ... and Expo to be held October 14–18, 2017 at the Mandalay Bay Resort ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company ... of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every ... meet the highest standard. , These products are also: Gluten Free, Non-GMO, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized ... have expanded their existing home health joint venture through an agreement, effective October ... a joint venture home health company with Asante, delivering clinically integrated care, for ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)...  According to the Centers for Disease Control and Prevention (CDC), ... Urgent Care is helping communities across Massachusetts , ... offering no-cost* flu shots through the end of the month. ... regulations. ... a flu shot is by the end of October, according to the ...
(Date:10/2/2017)... 2017  AllianceRx Walgreens Prime, the combined central specialty ... pharmacy benefit manager Prime Therapeutics LLC (Prime), today officially ... the unveiling of new signage at its headquarters in ... at a few other company-owned facilities across the country. ... some of whom will begin to see the AllianceRx ...
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans ... advance the use of wearable and home sensors for ... disorders. Early Signal Foundation, a nonprofit organization focused on ... will provide an affordable analytical system to record and ... ...
Breaking Medicine Technology: