Navigation Links
Epigenetic signals differ across alleles
Date:2/12/2010

Researchers from the Institute of Psychiatry (IoP), King's College London, have identified numerous novel regions of the genome where the chemical modifications involved in controlling gene expression are influenced by either genetic variation or the parental origin of that particular stretch of DNA. This contradicts previous assumptions that epigenetic signals are generally equal across both copies of a given region of the genome, except at a small number of known imprinted genes.

Sequencing the genome was only the first step in our quest to understand how genes are expressed and regulated. Epigenetics is the study of alterations to gene function, traditionally believed to occur independently of the DNA sequence. The epigenome sits above the DNA sequence and provides a second layer of information, regulating several genomic functions, including when and where genes are turned on or off. One of the best understood epigenetic mechanisms is DNA methylation, a chemical modification to DNA that can interfere with gene expression.

In the first quantitative genomic survey of allele-specific DNA methylation, published 11 Feburary 2010 in The American Journal of Human Genetics, scientists used sensitive high-throughput technology to detect evidence for skewed gene DNA methylation across both alleles - or copies - of the DNA sequence at almost 1 million positions in the genome.

Lead researcher Dr Jonathan Mill, Medical Research Council Social Genetic, Developmental and Psychiatry Centre at the IoP said: "Interestingly, we found numerous examples where DNA methylation was not equal across alleles - in some instances this depended upon genotype, and in other cases it depended upon which parent that allele was inherited from.

He continues: "Our data show that allele-specific DNA methylation is a widespread phenomenon with potentially over 35,000 such sites occurring across the genome. It appears that a spectrum of skewing is likely, differing between individuals and across tissues.

Dr Mill concludes: "These findings impact upon our understanding about the origin of biological variation and have implications for genetic studies of complex disease including most psychiatric conditions. Because DNA methylation can also be influenced by various environmental factors, the variation we have uncovered provides a potential substrate for interactions between nature and nurture."


'/>"/>

Contact: Erin Seymour
erin.seymour@kcl.ac.uk
44-207-848-5377
King's College London
Source:Eurekalert

Related medicine news :

1. Discovery of epigenetic memory during breast cancer
2. Johns Hopkins epigenetic center receives $16.8 million NIH grant
3. BioInformatics, LLC New Report - Exploring the Epigenetics Market: Opportunities for Product Placement and Innovations
4. Proteasome inhibition affects epigenetic mechanisms
5. Tackling a hard-to-treat childhood cancer by targeting epigenetic changes
6. Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes
7. First evidence that prenatal exposure to famine may lead to persistent epigenetic changes
8. New revelations in epigenetic control shed light on breast cancer
9. Senator Landrieu Closes Office: Constituents Turned Away at the Door, Callers Reach Only Busy Signals
10. New AERIUS Cell Phones Direct Microwave Signals Away from Users
11. Perceptual learning relies on local motion signals to learn global motion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... May 05, 2016 , ... A local study examining ... than 40 percent of participating fifth-grade students already have or are at risk ... Clinical Research in the Division of Pulmonary, Allergy and Critical Care Medicine at ...
(Date:5/5/2016)... NEW YORK (PRWEB) , ... May 05, 2016 , ... ... and swimming safety – today announced a new partnership to reach nearly 1 million ... can happen in an instant and is the leading cause of accidental death in ...
(Date:5/5/2016)... ... May 05, 2016 , ... Sun ... talk highlighting the organization’s successful Care Transitions program at the 9th ... was titled “Minimizing Costs in the Post-Acute Environment Through Effective Transitions of Care.” ...
(Date:5/5/2016)... ... , ... The 2016 Nike Soccer Camp will be directed by the 2015 ... Together they bring their winning Vandals coaching philosophy to young athletes. Programs are offered ... high school players. Session dates are as follows: , Youth Day Camp – July ...
(Date:5/5/2016)... ... May 05, 2016 , ... Talent Tech Labs (TTL) is pleased ... of National Nurses Week (May 6-12). Currently, HireNurses is a job listing ... into the Talent Tech Lab Virtual Incubation program, they will dramatically expand the functionality ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... WASHINGTON D.C. , May 4, 2016 /PRNewswire/ ... its member companies concluded a series of free ... training in global requirements for Good ... part of quality assurance which ensures that products are ... by the marketing authorization (MA) or product specification. Only ...
(Date:5/4/2016)... 4, 2016 Research ... "Global Acute Ischemic Stroke Market and Competitive ... offering.       (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Ischemic Stroke Market and Competitive Landscape Highlights ... Stroke pipeline products, Acute Ischemic Stroke epidemiology, ...
(Date:5/4/2016)... 4, 2016 Research ... "Global Acute lymphocytic Leukemia Market and Competitive ... offering.       (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Leukemia Market and Competitive Landscape Highlights 2016, ... pipeline products, Acute Lymphocytic Leukemia epidemiology, Acute ...
Breaking Medicine Technology: