Navigation Links
Epigenetic signals differ across alleles
Date:2/12/2010

Researchers from the Institute of Psychiatry (IoP), King's College London, have identified numerous novel regions of the genome where the chemical modifications involved in controlling gene expression are influenced by either genetic variation or the parental origin of that particular stretch of DNA. This contradicts previous assumptions that epigenetic signals are generally equal across both copies of a given region of the genome, except at a small number of known imprinted genes.

Sequencing the genome was only the first step in our quest to understand how genes are expressed and regulated. Epigenetics is the study of alterations to gene function, traditionally believed to occur independently of the DNA sequence. The epigenome sits above the DNA sequence and provides a second layer of information, regulating several genomic functions, including when and where genes are turned on or off. One of the best understood epigenetic mechanisms is DNA methylation, a chemical modification to DNA that can interfere with gene expression.

In the first quantitative genomic survey of allele-specific DNA methylation, published 11 Feburary 2010 in The American Journal of Human Genetics, scientists used sensitive high-throughput technology to detect evidence for skewed gene DNA methylation across both alleles - or copies - of the DNA sequence at almost 1 million positions in the genome.

Lead researcher Dr Jonathan Mill, Medical Research Council Social Genetic, Developmental and Psychiatry Centre at the IoP said: "Interestingly, we found numerous examples where DNA methylation was not equal across alleles - in some instances this depended upon genotype, and in other cases it depended upon which parent that allele was inherited from.

He continues: "Our data show that allele-specific DNA methylation is a widespread phenomenon with potentially over 35,000 such sites occurring across the genome. It appears that a spectrum of skewing is likely, differing between individuals and across tissues.

Dr Mill concludes: "These findings impact upon our understanding about the origin of biological variation and have implications for genetic studies of complex disease including most psychiatric conditions. Because DNA methylation can also be influenced by various environmental factors, the variation we have uncovered provides a potential substrate for interactions between nature and nurture."


'/>"/>

Contact: Erin Seymour
erin.seymour@kcl.ac.uk
44-207-848-5377
King's College London
Source:Eurekalert

Related medicine news :

1. Discovery of epigenetic memory during breast cancer
2. Johns Hopkins epigenetic center receives $16.8 million NIH grant
3. BioInformatics, LLC New Report - Exploring the Epigenetics Market: Opportunities for Product Placement and Innovations
4. Proteasome inhibition affects epigenetic mechanisms
5. Tackling a hard-to-treat childhood cancer by targeting epigenetic changes
6. Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes
7. First evidence that prenatal exposure to famine may lead to persistent epigenetic changes
8. New revelations in epigenetic control shed light on breast cancer
9. Senator Landrieu Closes Office: Constituents Turned Away at the Door, Callers Reach Only Busy Signals
10. New AERIUS Cell Phones Direct Microwave Signals Away from Users
11. Perceptual learning relies on local motion signals to learn global motion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... 25, 2016 , ... Casa Velas, an adults-only boutique hotel in Puerto Vallarta, ... its new wellness suites . The two 1,350 sq. ft. suites which debuted ... services and insuite amenities, from a custom soap selection and in-suite exercise kit to ...
(Date:5/25/2016)... , ... May 25, 2016 , ... America Walks ... Carol Reichbaum, M.S.L., M.S.P.A., of the University of Pittsburgh Graduate School of Public ... will enable Ms. Reichbaum and 24 other advocates from around the country to participate ...
(Date:5/25/2016)... ... May 25, 2016 , ... "FCPX LUT Intense allows ... your footage," said Christina Austin - CEO of Pixel Film Studios. , With ... and easily add stylish color grades to their footage. A LUT is a Lookup ...
(Date:5/25/2016)... ... May 25, 2016 , ... Consumer access to organic foods ... 2016, Kashi®, a maker of whole grain cereals and other plant-based foods, will introduce ... hard red winter wheat processed by Hesco/Dakota Organic Products. , The transitional designation ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... Stern ... firm will be selling the device branded as Stern’s Real Time Monitoring ... to bedbugs to the hotel and motel industry, colleges for use in dormitories, shelters, ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... May 24, 2016 Een app ... zodat zij collectief patiënten kunnen behandelen, hun kennis kunnen ... idee achter de nieuwe en revolutionaire MDLinking App, ontwikkeld ... Nederlandse vaatchirurg dr. Hans Flu en oncologisch chirurg dr. ... inmiddels beschikbaar is, wordt op dinsdag 24 mei officieel ...
(Date:5/23/2016)... FLINT, Mich. , May 23, 2016 Diplomat ... the third annual Fellowship and Internship programs. The hands-on ... 12. The full-time, paid Fellowship ... Flint, Michigan . Fellows and interns are ... downtown Flint at the Riverfront ...
(Date:5/23/2016)... , May 23, 2016 ... Devices, Diagnostics and Monitoring, and Vision Care ... Which areas are going to grow at the fastest ... revenues to 2026, assessing data, trends, opportunities and prospects. ... charts, and graphs. Discover the most lucrative areas in ...
Breaking Medicine Technology: