Navigation Links
Epigenetic factor likely plays a key role in fueling most common childhood cancer
Date:6/10/2013

(Memphis, Tenn. June 10, 2013) Changes in an epigenetic mechanism that turns expression of genes on and off may be as important as genetic alterations in causing pediatric acute lymphoblastic leukemia (ALL), according to a study led by scientists at St. Jude Children's Research Hospital and published in the June 10 online edition of the Journal of Clinical Investigation.

The results suggest the mechanism called cytosine methylation plays a previously under-appreciated role in the development of leukemia. Cytosine methylation involves adding or removing methyl groups to cytosine, which is a building block of DNA.

The study is the most comprehensive effort yet to identify and understand genetic and epigenetic factors that work together to cause ALL, the most common childhood cancer. ALL is a cancer of white blood cells known as lymphocytes. Scientists at St. Jude and Weill Cornell Medical College collaborated on the project.

Researchers used a variety of techniques to examine hundreds of thousands of methylation sites across the genome in normal and leukemic lymphocytes, including samples from more than 160 children with ALL. Investigators found that known ALL subgroups, which are defined by chromosomal alterations, have unique methylation profiles. Those profiles correlated with different patterns of gene expression.

"It is well known that different leukemia subgroups have distinct patterns of gene expression that are important in the development of leukemia," said Charles Mullighan, MBBS (Hons), MSc, M.D., an associate member of the St. Jude Department of Pathology. Mullighan and Ari Melnick, M.D., Gebroe Professor Hematology/Oncology at Weill Cornell Medical College, are the study's co-corresponding authors.

"We have assumed that the underlying genetic changes are important determinants of those gene expression profiles. We now know that changes in methylation state also have key roles in influencing gen
'/>"/>

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Astex, CRT and the Institute of Cancer Research announce epigenetic drug discovery collaboration
2. Epigenetics emerges powerfully as a clinical tool
3. New evidence for epigenetic effects of diet on healthy aging
4. Personal epigenetic signatures found consistent in prostate cancer patients metastases
5. Epigenetic control of cardiogenesis
6. Colon cancer exhibits a corresponding epigenetic pattern in mice and humans
7. A smoking gun in lung cancer epigenetics
8. BUSM authors propose potential epigenetic mechanisms for improved cancer therapy
9. UK study: Epigenetic changes play a key role in development of chemo resistance in BCa
10. Wellesley study shows income inequality a key factor in high US teen births
11. Social Factors May Affect Lifespan More Than Race, Location
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... (PRWEB) July 11, 2014 Utilizing the ... own, Dr. William Koenig, has topped a record number ... he has performed over 400 successful procedures without the ... Koenig is well known across the country for his ... safety record has long been the foundation for numerous ...
(Date:7/11/2014)... Ticket Down is a reliable source for cheap ... comes to the summer concert schedule, it just isn’t complete without ... of the biggest names in country music and one of the ... his “That’s My Kind of Night” tour featuring Lee Brice and ... through the rest of the summer and into the fall includes ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Biostimulants are ... growth in turf and ornamentals. These also help turf ... improve length of roots. Turf, ornamentals, and flowers appear ... Therefore, this usage has increased from the last few ... turf and ornamentals is Europe, with around 40% share ...
(Date:7/11/2014)... study of its kind has found that organic ... over their conventional counterparts, including more antioxidants and ... looked at an unprecedented 343 peer-reviewed publications comparing ... conventional plant-based foods, including fruits, vegetables, and grains. ... quantify differences between organic and non-organic foods. ...
(Date:7/11/2014)... July 11, 2014 Ticket Down is a reliable ... in Mountain View, CA. Over the years Luke Bryan has ... Not only does he do well at award shows, but each ... the most anticipated tours of the genre and this summer is ... artists can compare to the popularity and success that is currently ...
Breaking Medicine News(10 mins):Health News:Rochester Surgeon Hits Milestone with Keller Funnel 2Health News:Luke Bryan Ticket Prices Slashed at Concord Pavilion 2Health News:Luke Bryan Ticket Prices Slashed at Concord Pavilion 3Health News:Biostimulants Market in Turf and Ornamentals is Expected to Reach $ 3.8 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:Biostimulants Market in Turf and Ornamentals is Expected to Reach $ 3.8 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:Major study documents nutritional and food safety benefits of organic farming 2Health News:Major study documents nutritional and food safety benefits of organic farming 3Health News:Luke Bryan Tickets Shoreline Amphitheatre in Mountain View, CA: Ticket Down Slashes Ticket Prices for Luke Bryan in Mountain View at the Shoreline Amphitheatre 2Health News:Luke Bryan Tickets Shoreline Amphitheatre in Mountain View, CA: Ticket Down Slashes Ticket Prices for Luke Bryan in Mountain View at the Shoreline Amphitheatre 3
... The influence of genetics increases as young women transition from ... researchers at Washington University School of Medicine in St. Louis ... girls begin to drink, genes play a larger role if ... researchers studied 3,546 female twins ages 18 to 29 to ...
... Groundbreaking Program Addresses the Nursing Shortage By Supporting,1500 ... April 23 The Robert Wood Johnson,Foundation (RWJF) ... announced today the creation of the RWJF New ... nation,s nursing shortage by,dramatically expanding the pipeline of ...
... 23 Florida,s elected leaders,received a message from ... urging Governor Charlie Crist and legislative leaders not ... of the state,s most,vulnerable citizens., Driven by ... by gurney,the petitions ask Governor Crist, Senate President ...
... HEIGHTS, Ill. Lumpectomy or breast conservation surgery is ... performed. A benefit of the surgery is that only ... can be the resulting physical appearance of the breast, ... in Aprils Plastic and Reconstructive Surgery, the official medical ...
... New Business Alliance will help to raise funds ... K2 Logistics, an industry leader,focused on single-source supply ... spirit, K2 Logistics, headquartered in Eagan, announced,today its ... of,Minnesota (PAM) Team. Also joining in the fight ...
... Endocrine Society,s 90th Annual MeetingENDO 08will be held at ... 15-18, 2008. , Reporters can register here: ... all over the world are expected to assemble for ... endocrinology. , It is the opportunity for journalists ...
Cached Medicine News:Health News:Environment key early: Genes' role expands in alcohol dependence 2Health News:Environment key early: Genes' role expands in alcohol dependence 3Health News:Robert Wood Johnson Foundation Partners with AACN to Launch New Careers in Nursing Scholarship Program 2Health News:Robert Wood Johnson Foundation Partners with AACN to Launch New Careers in Nursing Scholarship Program 3Health News:Robert Wood Johnson Foundation Partners with AACN to Launch New Careers in Nursing Scholarship Program 4Health News:Thousands Sign Petitions Urging Governor Crist and Legislative Leaders to Save Healthcare Coverage for 40,000 Floridians 2Health News:Thousands Sign Petitions Urging Governor Crist and Legislative Leaders to Save Healthcare Coverage for 40,000 Floridians 3Health News:Breast reconstruction advances fix distortions left by lumpectomy 2Health News:K2 Logistics & Strategic Warehousing Join The Parkinson Association of Minnesota (PAM) Team! 2Health News:K2 Logistics & Strategic Warehousing Join The Parkinson Association of Minnesota (PAM) Team! 3Health News:ENDO 08: Latest news on hormones, steroids, obesity, diabetes and more 2
(Date:1/15/2014)... Mich. , Jan. 15, 2014 As health officials ... flu virus, select Meijer pharmacies in Michigan ... throat to eligible patients, enabling Meijer pharmacists to administer tests ... protocol set by a physician participating in the study. ...
(Date:1/15/2014)...  Celsion Corporation (the "Company") (NASDAQ: CLSN ) ... investors to purchase an aggregate of approximately $15 million ... direct offering, led by a dedicated health care fund. ... with these investors pursuant to which the Company agreed ...
(Date:1/15/2014)... Jan. 15, 2014  Humberto C. Antunes,  Galderma  worldwide CEO, ... the Journal of Drugs in Dermatology (JDD) ... (ODAC). The event is January 17-20, 2014, at the Omni Orlando ... The ODAC is a distinguished event ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4
... BEIJING, May 9, 2011 Saladax Biomedical, Inc., a ... to achieve the promise of personalized medicine for new ... Pacific Rim commercialization team to expand its presence in ... Rim commercialization team include: Yunying ...
... PLEASANTON, Calif., May 9, 2011 TriReme Medical, Inc. ... for the treatment of complex vascular disease, announced today ... Kleine to their Board of Directors. Mr. ... based in Singapore and was until recently Company Group ...
Cached Medicine Technology:Saladax Biomedical, Inc. Announces Pacific Rim Commercialization Team in Australia and China 2TriReme Medical Lines Up Asian Strategy With Key Appointment of New Board Members 2
... Beta 200 ophthalmoscope, ... glare-free direct ophthalmoscope. Heine's ... patent #4,963,014) along with ... construction, make the Beta ...
... optics. The separation of illumination and observation ... system avoids corneal and iris reflex (Gullstrand-principle). ... the whole of the illuminated section of ... Conventional ophthalmoscopes often let you see only ...
... Beta 200S is the first ... combination of patented aspherical optics ... range of corrective lenses from ... single diopter steps. A perfectly-focused ...
With the unique automatic focus system, Autofoc 2 remains the instrument of choice for direct ophthalmoscopy. Includes XHL halogen bulb....
Medicine Products: