Navigation Links
Epigenetic changes could explain type 2 diabetes
Date:3/7/2014

People with type 2 diabetes have epigenetic changes on their DNA that healthy individuals do not have. This has been shown in a major study by researchers at Lund University. The researchers also found epigenetic changes in a large number of genes that contribute to reduced insulin production.

"This shows that the risk of developing type 2 diabetes is not only genetic, but also epigenetic", said Charlotte Ling, who led the study.

Epigenetic changes occur as a result of factors including environment and lifestyle, and can affect the function of genes. Charlotte Ling and her colleagues have analysed insulin- producing cells of both healthy individuals and patients with type 2 diabetes. The analysis revealed epigenetic changes in approximately 800 genes in those with type 2 diabetes. Over 100 of the genes also had altered expression and many of these could contribute to reduced insulin production. Reduced insulin production is one of the underlying causes of type 2 diabetes.

In order to work out which is the chicken and which is the egg, i.e. whether the epigenetic changes are a consequence of the disease or if the disease is a result of the changes, the researchers also investigated whether healthy individuals had epigenetic changes caused by age, BMI and raised blood sugar levels.

"We were able to observe that a number of epigenetic changes had already taken place in healthy subjects as a result of age or high BMI, and were therefore able to conclude that these changes could contribute to the development of the disease", said Charlotte Ling. "Unlike genes that can't be changed, epigenetic changes are reversible", added Tasnim Dayeh, first author of the publication in PLOS Genetics.

Drugs that cause epigenetic changes have long been used in the treatment of cancer and epilepsy. The new survey changes the view of epigenetics in relation to diabetes, according to Charlotte Ling.

"It shows that epigenetics is of major significance for type 2 diabetes, and can help us to understand why people develop the condition. This also opens the way for the development of future drugs."


'/>"/>

Contact: Charlotte Ling
charlotte.ling@med.lu.se
46-706-145-146
Lund University
Source:Eurekalert

Related medicine news :

1. The epigenetics of breast cancer family history
2. Changes in epigenetic DNA functions reveal how diabetes predisposes individuals to Alzheimers
3. Changes in Epigenetic DNA Functions Reveal How Diabetes Predisposes Individuals to Alzheimer’s Disease
4. Chronic aggressive behavior in boys: Epigenetic sources?
5. Epigenetic changes to fat cells following exercise
6. Epigenetic factor likely plays a key role in fueling most common childhood cancer
7. UK study: Epigenetic changes play a key role in development of chemo resistance in BCa
8. BUSM authors propose potential epigenetic mechanisms for improved cancer therapy
9. A smoking gun in lung cancer epigenetics
10. Colon cancer exhibits a corresponding epigenetic pattern in mice and humans
11. Epigenetic control of cardiogenesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... ... publication of “Profiling protein expression in circulating tumor cells using microfluidic western blotting” ... use of the Vortex technology to capture CTCs and a microfluidic ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... Milpitas with a robust, ongoing community enrichment program, has announced their latest charity ... which has provided for the critical needs of homeless families with children for ...
(Date:3/22/2017)... ... March 22, 2017 , ... In recognition of Colon ... enterprise focused on cancer patients, cancer centers and advocacy groups, and MJH Studios™, ... video series, “No Ifs, Ands, or Butts,” that focuses on Colorectal Cancer detection, ...
(Date:3/22/2017)... ... March 22, 2017 , ... Drs. Jennifer Houck, Lauren ... base to accept new patients in need of skilled pediatric dentistry in ... Dental Care offers pediatric patients routine treatments, including cavities, sealants and fluoride applications, in ...
(Date:3/22/2017)... ... March 22, 2017 , ... The Carballo Agency, ... and the New York metropolitan region, is embarking on a cooperative charity drive ... , At present, more than two and a half million children in the ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... ROCHESTER, N.Y. , March 22, 2017 /PRNewswire/ ... Steriliz R-D™ Rapid Disinfector™ is the proven ultraviolet-C ... that cause healthcare-associated infections (HAIs). ... American Journal of Infection Control , the peer-reviewed ... testing and experiences of Vancouver General Hospital and ...
(Date:3/22/2017)... 22, 2017 FinancialBuzz.com News Commentary ... rapidly due to the significant development and innovation in ... Market Research, the global electrophysiology market was worth $3.42 ... billion by 2022, with a GAGR of 13.4%. Electrophysiology ... diagnose abnormal heartbeats or arrhythmia. The report indicates that ...
(Date:3/22/2017)... , March 22, 2017 Kalorama Information has ... important to those following the industry.  This month the FDA ... test, and the POC testing market has reached $18.4 ... subsidiary is facing a legal battle and the acquisition ... Coulter launched a new chemistry analyzer and researchers ...
Breaking Medicine Technology: