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EpiCept to Present Preclinical Studies of EPC2407 in Combination With Anti-Angiogenic and Chemotherpeutic Agents at the AACR-NCI-EORTC International Conference
Date:10/22/2007

TARRYTOWN, N.Y., Oct. 22 /PRNewswire-FirstCall/ -- EpiCept Corporation (Nasdaq and OMX Nordic Exchange: EPCT) today announced that Dr. Ben Tseng, Chief Scientific Officer, will present the results of studies examining the combination of EPC2407 with cancer therapeutics in preclinical animal models at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in San Francisco, CA on October 24, 2007. EPC2407 is EpiCept's novel small molecule vascular disruption agent and apoptosis inducer for the treatment of patients with advanced solid tumors and lymphomas that recently completed enrollment in a Phase Ia single agent trial.

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The preclinical studies examined the effectiveness of combining EPC2407 with an anti-angiogenesis inhibitor, Avastin(R) or Sutent(R), or with the chemotherapeutic agent cisplatin. EPC2407 was administered in combination with a cancer therapeutic agent in mouse xenograft models of human non-small cell lung carcinomas and human breast carcinomas. These studies indicated significantly enhanced anti-tumor activity when EPC2407 was added to the therapeutic regimen, compared with either agent administered alone, which resulted in increased median survival and number of tumor-free animals well after the end of treatment (>2.5 months). The results demonstrated additive to synergistic activity when EPC2407 is used in combination with these cancer therapeutics.

These results strongly support the clinical testing of EPC2407 in combination with different anti-cancer agents. Advancement of EPC2407 in clinical trials to Phase Ib combination studies is planned to initiate in early 2008.

About EpiCept Corporation

EpiCept is focused on unmet needs in the treatment of pain and cancer. EpiCept has a staged portfolio of pharmaceutical product candidates
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