Navigation Links
Enzyme's second messenger contributes to cell overgrowth

Scientists at the University of California, San Diego (UCSD) School of Medicine have uncovered a novel pathway by which hormones elevated in inflammation, cancer and cell injury act on cells to stimulate their growth.

The research team led by Joan Heller Brown, Ph.D., professor and chair of the department of pharmacology at UCSD, has demonstrated in a mouse model that a newly discovered subtype of the phospholipase C (PLC) family of enzymes, called PLC-epsilon, has the unique ability to activate a second and distinct signaling pathway that cells require for proliferation. The study is currently on line in advance of publication by the Proceedings of the National Academy of Science (PNAS.)

The studies reported in the PNAS demonstrate that in the cell, hormones that activate small G proteins are highly dependent on PLC- to generate second messengers, said Heller Brown. In addition, and more surprisingly, we discovered that this enzyme is required for cell growth because it serves a second function when activated by hormones.

Many intracellular signaling proteins work as molecular switches. The reception of a signal activates them and causes them to pass the signal through the cell, after which they can be switched off until another signal is received. G proteins are a commonly used form of switch, activated by the binding of guanine nucleotides. PLCs normal role is delivering signals from outside the cell to inside the cell by generating second messengers that tell cells to contract and secrete. But these signals alone are not enough to cause cells to increase their growth. The first author of the paper, Simona Citro, Ph.D., and colleagues found that PLC- uniquely activates a second and distinctly different signaling cascade. This second signal catalyzes activation of a Ras family of small G proteins associated with cell growth.

In combination with the first set of signals, this can lead to cell proliferation and could contribute to inflammation or cancer if left unchecked, said Citro.

PLC plays a critical role in physiological processes including heart function, cell secretion and blood pressure control, so one would not normally want to block its activity, added Heller Brown. The UCSD researchers discovery may enable scientists to target this novel PLC isoform or inhibit only its second function, preventing pathological responses while leaving PLCs critical positive role intact.


Contact: Debra Kain
University of California - San Diego

Related medicine news :

1. Smoking Hazardous To The Enzymes System In Lungs
2. Bad Enzymes Found To Enable Brain Recovery Following Stroke
3. New Role of COX Enzymes Discovered
4. Immune System Gears Up by Specific Enzymes
5. Study Attributes Elevated Liver Enzymes in HIV/hepatitis to Coinfection Rather Than Antiretrovirals
6. Surgeons implant second artificial heart
7. Second hope for men with erectile dysfunction
8. Second SARS suspect fuels worry in India
9. Animals Can give us a second chance at life
10. Animals can give us a second chance at life
11. The Harmful Effects Of Secondhand Smoke
Post Your Comments:
(Date:11/25/2015)... Omaha, Neb. (PRWEB) , ... November 25, 2015 ... ... nurse staffing companies, has been recognized once again for its stellar workplace culture ... Places to Work.” , Medical Solutions’ Cincinnati office was named a ...
(Date:11/25/2015)... ... November 25, 2015 , ... For the first time, Vitalalert is ... One Beat ” campaign. The partnership between the two groups began in 2014 with ... International’s cause. , MAP International was founded in 1954 and is an international Christian-based ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... and athletic programs, launches new Wimbledon Athletics Facebook page to educate ... athletes for unsuspected cardiac abnormalities. About 2,000 people under the age of 25 ...
(Date:11/25/2015)... ... , ... Beddit® has launched a new Android app for use ... a more intuitive SleepScore™ that rates sleep quality on a 100-point scale and makes ... by a proprietary algorithm. Beddit analyzes the data to provide an easy to understand ...
(Date:11/25/2015)... ... November 25, 2015 , ... Castlewood Treatment ... struggling with eating disorders as a result of the $20,000 raised at the ... at Fox Run Golf Club in Eureka, will help individuals who otherwise might ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... -- The total global healthcare industry is expected to grow at ... America has the highest projected growth at 12.7%, ... ), is second with growth projected at 11.5%. ... expenditure. In 2013-2014, total government funded healthcare was nearly 68%. ... 41.2% in 2013-2014. In real terms, out of pocket expenditure ...
(Date:11/25/2015)... WOODBURY, N.Y. , Nov. 25, 2015  Linden ... access and optimizing treatment outcomes for patients suffering from ... its request for a Temporary Restraining Order (TRO) enjoining ... between the two companies. --> ... aggressively pursuing all of its legal options. ...
(Date:11/25/2015)... USA , Inc., a leader in ... accuracy of its blood glucose meter systems. Last week ... Cardiovascular Disease in Los Angeles , ... 01 meter and the Assure ® Prism multi-user ... measure glucose levels in blood is essential for people ...
Breaking Medicine Technology: