Navigation Links
Enzyme's second messenger contributes to cell overgrowth
Date:9/26/2007

Scientists at the University of California, San Diego (UCSD) School of Medicine have uncovered a novel pathway by which hormones elevated in inflammation, cancer and cell injury act on cells to stimulate their growth.

The research team led by Joan Heller Brown, Ph.D., professor and chair of the department of pharmacology at UCSD, has demonstrated in a mouse model that a newly discovered subtype of the phospholipase C (PLC) family of enzymes, called PLC-epsilon, has the unique ability to activate a second and distinct signaling pathway that cells require for proliferation. The study is currently on line in advance of publication by the Proceedings of the National Academy of Science (PNAS.)

The studies reported in the PNAS demonstrate that in the cell, hormones that activate small G proteins are highly dependent on PLC- to generate second messengers, said Heller Brown. In addition, and more surprisingly, we discovered that this enzyme is required for cell growth because it serves a second function when activated by hormones.

Many intracellular signaling proteins work as molecular switches. The reception of a signal activates them and causes them to pass the signal through the cell, after which they can be switched off until another signal is received. G proteins are a commonly used form of switch, activated by the binding of guanine nucleotides. PLCs normal role is delivering signals from outside the cell to inside the cell by generating second messengers that tell cells to contract and secrete. But these signals alone are not enough to cause cells to increase their growth. The first author of the paper, Simona Citro, Ph.D., and colleagues found that PLC- uniquely activates a second and distinctly different signaling cascade. This second signal catalyzes activation of a Ras family of small G proteins associated with cell growth.

In combination with the first set of signals, this can lead to cell proliferation and cou
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Smoking Hazardous To The Enzymes System In Lungs
2. Bad Enzymes Found To Enable Brain Recovery Following Stroke
3. New Role of COX Enzymes Discovered
4. Immune System Gears Up by Specific Enzymes
5. Study Attributes Elevated Liver Enzymes in HIV/hepatitis to Coinfection Rather Than Antiretrovirals
6. Surgeons implant second artificial heart
7. Second hope for men with erectile dysfunction
8. Second SARS suspect fuels worry in India
9. Animals Can give us a second chance at life
10. Animals can give us a second chance at life
11. The Harmful Effects Of Secondhand Smoke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2015)... Indiana Fiber Network, LLC (IFN), the ... Services, Inc (BCS) has selected IFN as a fiber ... technology, service, and working relationship with IFN has been ... feel you get with IFN. I like dealing ... local decisions and operates as a local community business ...
(Date:5/3/2015)... Boston, MA (PRWEB) May 03, 2015 ... received clearance from the FDA to produce and market ... This device can be used in outpatient settings and ... , The alternate posterior approach has been extensively researched ... a 510k approval to use this approach in conjunction ...
(Date:5/2/2015)... 02, 2015 Ticket Down has secured additional ... the long awaited event today, Saturday, May 2nd at the ... fans will be able to secure tickets for both the ... that boxing fans have wanted for more than five years ... “Money” Mayweather will step inside the ring to fight Manny ...
(Date:5/2/2015)... May 02, 2015 It’s a pattern ... natural disaster strikes anywhere on this planet, cyber scammers ... sympathy and compassion for their own personal gain. ... Emergency Readiness Team) issued an alert titled “Nepal ... email scams citing the earthquake in Nepal. The scam ...
(Date:5/2/2015)... Kare Visits LLC. launched in Chicago in response to the ... offers relief for caregivers by visiting loved ones in nursing ... the Caregiver Action Network, eight in ten caregivers are employed. ... caring for an elderly or disabled loved one. For ... caregiver is now empowered to schedule an on demand visit ...
Breaking Medicine News(10 mins):Health News:Bank Computer Services, Inc Selects Indiana Fiber Network, LLC as Fiber Transport Provider 2Health News:Bank Computer Services, Inc Selects Indiana Fiber Network, LLC as Fiber Transport Provider 3Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 2Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2
... ... Vouchers Via Twitter to Support the Launch of the New Video Marketing Quiz. , ... (PRWEB) March 9, 2010 -- EyeView , the ... Video Marketing Quiz on Wednesday March 10, 2010 at 10 am ET. The ...
... ... combined their industry leading technologies to provide the most sensitive tools for monitoring apoptosis in ... ... have combined their industry leading technologies to provide the most sensitive tools for monitoring apoptosis ...
... ... ... ... ...
... ... ... ... ...
... when the price went up, study found , TUESDAY, March ... people consume less of it, a new study has found. , ... adults, aged 18 to 30, beginning in 1985 to 1986 and ... percent increase in price was associated with a 7 percent decrease ...
... ... employees and positive business outcomes. , ... Charlotte, NC (Vocus) March 9, 2010 -- Morehead , the ... free hour-long webinar will be broadcast on Tuesday, March 30, 2010 at 1:00 p.m. ...
Cached Medicine News:Health News:EyeView Launches Innovative Video Marketing Quiz 2Health News:EyeView Launches Innovative Video Marketing Quiz 3Health News:Promega - TOP srl Agreement Enables Live Animal Imaging for Cancer Studies 2Health News:Wanted: Indianapolis Customer Service Professionals 2Health News:Wanted: Indianapolis Customer Service Professionals 3Health News:Wanted: Indianapolis Customer Service Professionals 4Health News:Wanted: Indianapolis Customer Service Professionals 5Health News:World's First 3D Dance DVD Released! 2Health News:World's First 3D Dance DVD Released! 3Health News:Cost of Junk Food May Influence Consumption 2Health News:Morehead Webinar to Discuss Building Workforce Commitment 2
(Date:5/1/2015)...   Intarcia Therapeutics, Inc. today announced the ... President, Human Resources, reporting directly to Kurt Graves ... key member of the senior leadership team, Mr. Brady ... to assure the Company advances its business, brings in ... values and its dynamic culture. Another essential goal for ...
(Date:5/1/2015)... 1, 2015 CANTEL MEDICAL CORP. (NYSE: CMN ... Executive Officer, will be presenting at the Bank of America ... Wynn in Las Vegas, NV. The ... 10:00 AM PT/1:00 PM ET. In addition, management will be ... An audio webcast will be available via the investor ...
(Date:5/1/2015)... , May 1, 2015  Portal Instruments, Inc., an ... systems, announced today that Robert Langer, Sc. D., ... University of Auckland Distinguished Professor have joined the company,s ... welcome two esteemed biotechnology leaders, Professor Robert Langer ... team," said Dr. Patrick Anquetil , Chief Executive ...
Breaking Medicine Technology:Intarcia Appoints James P. Brady Vice President, Human Resources 2Intarcia Appoints James P. Brady Vice President, Human Resources 3Intarcia Appoints James P. Brady Vice President, Human Resources 4Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 2Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 3Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 4
... March 1, 2011 Practice Fusion, the ... in the US, today announced Jason Portnoy as the ... free, cloud-based EMR to physicians; enabling charting, scheduling, e-prescribing ... period of rapid expansion, bringing his deep expertise in ...
... IRVINE, Calif., March 1, 2011 Uptake Medical ® ... of lung diseases including emphysema , announced today that ... (Nasdaq: VOLC ) has joined the company,s Board ... CEO and Director of Volcano since April 2002. He led ...
Cached Medicine Technology:Former PayPal, Palantir Executive Jason Portnoy Joins Practice Fusion as CFO 2Former PayPal, Palantir Executive Jason Portnoy Joins Practice Fusion as CFO 3Uptake Medical Announces Scott Huennekens Elected to Board of Directors 2
... unique DHEA-S-7kits feature a ... against the C-7 position ... with no cross-reactivity with ... RIA has been optimized ...
... based on the competition principle and the ... present in the sample and a fixed ... compete for the binding sites of a ... After one hour incubation the microtiterplate is ...
Inquire...
... It is a compact Latex based reagent kit ... well as to determine the level of RF ... patient sera. The kit includes antigen coated fine ... control sera in plastic squeezable dropping bottles, re-usable ...
Medicine Products: