Navigation Links
Enzymes implicated in disease processes attack one another instead of harming body proteins
Date:8/13/2012

Researchers for the first time have shown that members of a family of enzymes known as cathepsins which are implicated in many disease processes may attack one another instead of the bodily proteins they normally degrade. Dubbed "cathepsin cannibalism," the phenomenon may help explain problems with drugs that have been developed to inhibit the effects of these powerful proteases.

Cathepsins are involved in disease processes as varied as cancer metastasis, atherosclerosis, cardiovascular disease, osteoporosis and arthritis. Because cathepsins have harmful effects on critical proteins such as collagen and elastin, pharmaceutical companies have been developing drugs to inhibit activity of the enzymes, but so far these compounds have had too many side effects to be useful and have failed clinical trials.

Using a combination of modeling and experiments, researchers from the Georgia Institute of Technology and Emory University have shown that one type of cathepsin preferentially attacks another, reducing the enzyme's degradation of collagen. The work could affect not only the development of drugs to inhibit cathepsin activity, but could also lead to a better understanding of how the enzymes work together.

"These findings provide a new way of thinking about how these proteases are working with and against each other to remodel tissue or fight against each other," said Manu Platt, an assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. "There has been an assumption that these cathepsins have been inert in relationship to one another, when in actuality they have been attacking one another. We think this may have broader implications for other classes of proteases."

The research was supported by the National Institutes of Health, the National Science Foundation and the Georgia Cancer Coalition. Details of the study were reported August 10 in the Journal of B
'/>"/>

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Clemson researchers collect and reuse enzymes while maintaining bioactivity
2. FDA Gives Nod to First Drug for Diabetic Eye Disease
3. Humira Might Help Kids With Tough-to-Treat Crohns Disease
4. Depression linked with increased risk of peripheral artery disease
5. Underinsured Heart Disease Patients Die Sooner, Study Finds
6. New drug successfully halts fibrosis in animal model of liver disease
7. Genetic analyses reveal novel mutations as causes of startle disease
8. Adalimumab is a promising therapy for children with Crohns disease
9. Most Americans With Celiac Disease Dont Realize It: Study
10. Detecting thyroid disease by computer
11. Caffeine May Help Treat Parkinsons Disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Enzymes implicated in disease processes attack one another instead of harming body proteins
(Date:7/29/2014)... -- Although the bite of a brown recluse spider ... alone, an expert notes. It,s still important to ... a brown recluse spider bite, warned Dr. Donna Seger, ... these potentially dangerous bites are on the rise. ... nothing. The [bite] has classic characteristics, but if physicians ...
(Date:7/29/2014)... Using quality improvement measures in eight of the ... Study Group, researchers have found a way to reduce ... dye. , Currently, 7-15 percent of these patients who ... with kidney injury, which can result in death or ... permanent dialysis, says a study published in the July ...
(Date:7/29/2014)... 29, 2014 New high priced hepatitis ... D by a projected $2.9 to $5.8 billion next ... firm Milliman released today by the Pharmaceutical Care Management ... could increase by as much as 8.6 percent in ... including Sovaldi and Olysio. , The study finds that ...
(Date:7/29/2014)... Alto, CA (PRWEB) July 29, 2014 ... and well-being in older adults. Once again, the non-profit agency ... Celebration, a free event for seniors. , This event gives ... active and maintain better health. There will be a variety ... and dancing, wellness vendors, tech demonstrations and artists. In addition, ...
(Date:7/29/2014)... donor kidney transplants receive steady follow-up care, the ... To make follow-up care more accessible, UC San ... collaborating to launch the first program in the ... charge to living kidney donors. , UCSF will ... more than 4,500 Walgreens pharmacies and Healthcare Clinic ...
Breaking Medicine News(10 mins):Health News:Brown Recluse Spider Bites on the Rise, Expert Warns 2Health News:Reducing kidney injury using a quality improvement method 2Health News:New Milliman Study: Hepatitis C Drugs Could Increase Medicare Part D Spending by $2.9 to $5.8 Billion in 2015 2Health News:Avenidas Hosts Third Annual Successful Aging Celebration 2Health News:Caring for donors 2Health News:Caring for donors 3
... Web site,s c ontent is ... CHICAGO, July 15 In an emergency, immediate access to ... death. Personal health records (PHRs) often help ease the tension and ... encounters. To increase its PHR public outreach, the American Health Information ...
... , Goodman: Bill Contains All the Bad ... DALLAS, July 15 The Democrats, health care reform bill currently ... health plan that will undercut the private market and force as many ... forced into a Medicare-like plan, according to National Center for Policy Analysis ...
... , Dr. Thomas Bryant Brings Hill ... WASHINGTON, July 15 The National Coalition of Mental ... Bryant, MD, JD, as its first-ever Director of Government Relations. Dr. ... excited to join the staff of the National Coalition. The most ...
... HMSY ) today announced it will host a webcast and conference call at 9:00 am ET on ... which ended June 30. Financial results are scheduled for release before the market opens on Friday, ... William Lucia, CEO, Walter Hosp, CFO, ... 9:00 AM ET, , , HOW: Presentation: , ...
... , , American Society of ... s Water and Wastewater Infrastructure Systems , ... owe our health and much of our quality of life to the ... water and wastewater systems on which we rely. Despite the importance of ...
... , BETHESDA, Md., July 15 ... solutions, today announced the release of the PatientLife System(R) 3.5 (PLS ... focused on accelerating the discharge planning process and reducing average length ... , "We are excited about the new functionality of ...
Cached Medicine News:Health News:AHIMA Launches New Interactive myPHR.com Web Site 2Health News:AHIMA Launches New Interactive myPHR.com Web Site 3Health News:House Democrat's Health Care Reform Bill Is a 1,018-Page Nightmare 2Health News:National Coalition of Mental Health Consumer/Survivor Organizations Hires Director of Government Relations 2Health News:HMS Holdings Corp. Hosts Second Quarter 2009 Financial Teleconference and Presentation 2Health News:Proposed Water Trust Fund Bill Would Provide Solid Foundation for Improvement 2Health News:GetWellNetwork Introduces Discharge Planning Tools in Latest Version of PatientLife System 2Health News:GetWellNetwork Introduces Discharge Planning Tools in Latest Version of PatientLife System 3Health News:GetWellNetwork Introduces Discharge Planning Tools in Latest Version of PatientLife System 4
(Date:7/29/2014)... -- Sequenom, Inc. (NASDAQ: SQNM ), a life ... total revenues of $39.8 million for the second quarter ... of $24.5 million for the second quarter of 2013. ... sold on May 30, 2014, has been accounted for ... been excluded from continuing operations for all periods. ...
(Date:7/29/2014)... July 29, 2014 Pfenex Inc. (NYSE MKT: PFNX) ... public offering of 8,333,333 shares of its common  stock at ... of the common stock was offered by Pfenex. In addition, ... up to 1,250,000 additional shares of common stock at the ... traded on the NYSE MKT under the symbol "PFNX." ...
(Date:7/29/2014)... 29, 2014  EnteroMedics Inc. (NASDAQ: ETRM ... to treat obesity, metabolic diseases and other gastrointestinal disorders, ... on Thursday, August 7, 2014 at 11:00 AM Eastern ... ended June 30, 2014 and to provide a business ... second quarter conference call may be accessed by dialing ...
Breaking Medicine Technology:Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 2Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 3Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 4Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 5Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 6Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 7Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 8Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 9Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 10Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 11Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 12Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 13Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 14Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 15Sequenom, Inc. Reports Financial Results For The Second Quarter Of 2014 16Pfenex Announces Closing of Initial Public Offering 2EnteroMedics to Host Second Quarter 2014 Financial Results and Business Update Conference Call 2EnteroMedics to Host Second Quarter 2014 Financial Results and Business Update Conference Call 3
... 2011 A west coast secret is finally reaching the ... from Beverly Hills, California, a health and beauty boutique named ... ).  A clinically tested dietary supplement is helping thousands of ... than 4 weeks of use.  Just a few capsules per ...
... SAN DIEGO, Sept. 29, 2011 Awarepoint ... system (RTLS) solutions for healthcare, announced today that ... (RFID) and RTLS Healthcare Competitive Strategy Leadership ... pioneering and providing complete RTLS and workflow automation ...
Cached Medicine Technology:Beverly Hills Secret Now Helping People Across The Country 2Awarepoint Corporation Receives Frost & Sullivan's 2011 North American RFID and RTLS Healthcare Competitive Strategy Leadership Award 2Awarepoint Corporation Receives Frost & Sullivan's 2011 North American RFID and RTLS Healthcare Competitive Strategy Leadership Award 3
BD Visitec IOL Manipulator (Sinskey), blunt tip angled 45, 15.0 mm from end, fits 0.20 mm diameter holes and larger (3/bx, 1 bx/ca), sterile. For positioning intraocular lenses. Sure grip handles han...
... BD Visitec IOL Manipulator (Jaffe-Maltzman), ... mm from end, fits 0.20 ... for positioning intraocular lenses, (3/bx, ... intraocular lenses. Sure grip handles ...
Maltzman-Fenzl lens manipulator, V shaped tip, straight. Also available in titanium....
Sinskey lens manipulator, straight. Also available in titanium....
Medicine Products: