Navigation Links
Enzyme weakens the heart
Date:2/17/2009

An enzyme makes the mouse heart prone to chronic cardiac insufficiency if it is suppressed, the heart remains strong despite increased stress. Cardiologists at the Internal Medicine Clinic at Heidelberg University Hospital in cooperation with scientists at the University of Texas Southwestern Medical Center at Dallas and Gttingen University Hospital have now explained this key mechanism in a mouse model and thus discovered a promising approach for the systematic prevention of chronic cardiac insufficiency. The study has now been published online before print in the prestigious journal Proceedings of the National Academy of Sciences.

Long-term high pressure and stenoses of the valves or aorta make the heart work harder. When it compensates by excessive muscle growth (cardiac hypertrophy), the pump function is affected rhythm disorders or heart failure can be the result. Other risk factors are overweight and age more than 40 percent of people over age 70 suffer from cardiac muscle hypertrophy.

Despite progress in medication, around 95,000 people in Germany die annually from the consequences of chronic cardiac insufficiency. "It is essential to find the molecules that are key to the development of cardiac insufficiency in order to develop new, more efficient treatment" states Dr. Johannes Backs, head of a research group in the Department of Cardiology, Angiology, and Pneumonology (Director Prof. Dr. med. Hugo A. Katus) at Heidelberg University Hospital.

Enzyme activates stress response and hypertrophy of the heart

A key molecule for cardiac hypertrophy brought on by stress is the naturally occurring enzyme CaMKII delta (Calcium/Calmodulin-dependent kinase II delta). Dr. Backs' international research team proved this in genetically modified mice that could no longer produce this enzyme by surgically obstructing the main aorta to put the heart under greater stress and thus simulate permanent high blood pressure or valve stenosis in humans. The anticipated enlargement of the heart was very slight the animals were protected.

"With these mice, we succeeded for the first time in specifically suppressing the CaMKII delta enzyme and clarifying its function in detail," said Dr. Backs. CaMKII delta has a direct effect on the cells' stress response. If it is missing, certain information in cell DNA is not accessed that is normally activated by stress, leading to hypertrophy of the heart. "There was still some slight enlargement of the heart, but presumably not enough to cause cardiac insufficiency," said Dr. Backs. Under normal conditions, the genetically modified mice are inconspicuous their hearts function and react normally.

The function of CaMKII delta as an intermediate of the heart's stress response is a possible approach for effective therapy the Heidelberg researchers anticipate that agents that block only this function of the enzyme would prevent the heart muscle from reacting to overload. Other functions of CaMKII delta should not be affected in order to avoid harmful side effects.


'/>"/>

Contact: Dr. Johannes Backs
johannes.backs@med.uni-heidelberg.de
49-622-156-37714
University Hospital Heidelberg
Source:Eurekalert

Related medicine news :

1. Durability of dental fillings improves if the enzyme activity of teeth is inhibited
2. Unique Glutathione Reductase Enzyme Introduced by Bio-Research Products
3. Enzyme with a sugar antenna
4. Low Levels of 2 Enzymes in Ovarian Cancer Cells Shortened Survival
5. Millennium Research Group Analyst Available to Comment on FDAs Premarket Approval Recommendation of Genzyme Biosurgerys Synvisc Single-Injection Product for the Knee
6. Scientists ID Enzyme Causing Brain Cell Death
7. Researchers discover new enzyme in cancer growth
8. Broccoli compound targets key enzyme in late-stage cancer
9. IDO2 an active enzyme to target in pancreatic cancer
10. Genetic disorder sheds light on enzymes role in bone metabolism
11. AUDIO from Medialink and Genzyme: Study in New England Journal of Medicine Shows Investigational Compound Reduced Relapses and Disability in Patients With MS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... August 18, 2017 , ... Paragon and ... database to help the cannabis industry move towards greater legitimacy. By incorporating IOTA’s ... faster technology with lower fees. Paragon will build a fully verifiable database to ...
(Date:8/19/2017)... ... August 19, 2017 , ... Yesterday, the President of the United States ... two sides. There are not two sides to hatred, bigotry, discrimination, and a white ... and the NPEIV stands against all forms of such hatred and discrimination in this ...
(Date:8/18/2017)... ... August 18, 2017 , ... More than 20,000 pairs of shoes made ... thanks to an ambitious venture that conjoined the passions of an NBA star, a ... the Liberty community. These shoes will save lives from the rampant infections transmitted through ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... “Vision & Hearing” campaign, advocating for active, healthy lifestyles and highlighting the importance ... for individuals with hearing impairments and shares the latest innovations in hearing aid ...
(Date:8/18/2017)... ... August 18, 2017 , ... Moore Insurance, a Houston area ... Texas, is launching a regional charity effort to provide publicity assistance and generate ... Brain Tumor Foundation (PBTF) has raised nearly $30 million in donations that has ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), ... Board of Directors has approved the payment of a quarterly ... The cash dividend of ... 27, 2017 to stockholders of record as of the close ... are subject to approval of the Board of Directors and ...
(Date:8/7/2017)...  Endo International plc (NASDAQ: ENDP ) ... all known U.S. mesh product liability claims and that ... remaining U.S. claims at reasonable values. Under the agreements, ... quarter of 2017 and continuing through the fourth quarter ... results, the Company intends to increase its mesh product ...
(Date:8/3/2017)... SAN DIEGO , Aug. 3, 2017  Opioid ... crippling diseases driving up healthcare costs and threatening outcomes, ... the lab supply and IVD industry that support them, ... health care market researcher said that drugs of abuse, ... vendors and sessions at the organization,s 69th meeting in ...
Breaking Medicine Technology: