Navigation Links
Enzyme may hold key to improved targeting of cancer-fighting drugs
Date:5/29/2008

CHESTNUT HILL, MA A critical enzyme used to prepare a powerful cancer-killing agent may be able to help drug makers better target the cells the natural product attacks, according to findings published in the May 23 edition of the Journal of Biological Chemistry.

Building on their earlier research into neocarzinostatin, a team of researchers from Boston College and the University of Wisconsin, Madison discovered that one of the enzymes contained in the bacteria used to produce the drug may hold promise in creating newer, more stable compounds from the structurally complex class of antibiotic known as chromoproteins.

"We've revealed that the enzyme is loose in specificity, which means it may be able to be used to make new drugs," said Boston College Chemist Steven D. Bruner, a co-author of the report. "Based on these findings, we foresee success in the lab making certain compounds more controllable."

In addition to Bruner, the research team includes BC graduate student Heather A. Cooke and University of Wisconsin Professor Ben Shen and researchers Yinggang Luo, Shuangjun Lin and Jian Zhang.

Used as a chemotherapeutic, the drug an enediyne anti-tumor agent targets both normal and cancer cells, says Bruner, an assistant professor of chemistry. But the team has determined that the chemical components of the antibiotic are capable of distinguishing between normal cells and cancer cells.

The latest research confirmed the team's proposal that the naphthoic acid within the compound can be altered to design cancer-fighting drugs specific to chemotherapeutic targets. That will require the use of genetic engineering in order to manipulate the molecules within the bacteria, which occurs naturally in soil.

Genetic engineering will enable researchers to produce more specific and less toxic analogs of neocarzinostatin and increase the available supply of the drug, Bruner says.

"This is the beginning of an approach to be able to understand and manipulate these chemical pathways to make new drugs," says Bruner.


'/>"/>

Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert

Related medicine news :

1. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
2. Elliott Extremely Dissatisfied With Genzyme Bid for Bioenvision; Believes Offer Significantly Undervalues Company
3. Scientists reveal DNA-enzyme interaction with first ever real time footage
4. UCSD study reveals the regulatory mechanism of key enzyme
5. UCSD study reveals the regulatory mechanism of key enzyme
6. Enzymes second messenger contributes to cell overgrowth
7. Delaware Court Approves Bioenvision, Genzyme Joint Petition
8. Genzyme and Bayer Schering Pharma AG, Germany to Present New Data on Alemtuzumab in Multiple Sclerosis at ECTRIMS
9. Genzyme Statement Regarding Results of FDA Advisory Committee Meeting on the Use of Phosphate Binders in Chronic Kidney Disease
10. Bioenvision Shareholders Approve Acquisition by Genzyme Corporation
11. Role of a key enzyme in reducing heart disease identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... Netc , a leading provider of barcode and ... Inc. The Dataware acquisition enables Netc to continue to grow its label business, customer base ... provides customers with the ability to print and label tape media on site and on ...
(Date:5/3/2016)... ... May 04, 2016 , ... ... That message is reaching the global health community through expanding activities that embrace ... of cancer in the resource-limited countries. , In support of this ...
(Date:5/3/2016)... ... May 03, 2016 , ... ProIntro Glitch is a set of ... Film Studios’ titles allow users to add a terrifying opener to any video or ... lines and accents. To add greater contrast, all the user has to do is ...
(Date:5/3/2016)... ... ... In April, Amerec launched a new website designed with optimal user experience in ... sauna solutions. , First, the Amerec website has been redesigned to be easier to ... features, especially the Steam Builder Tool , to both mobile and desktop devices. ...
(Date:5/3/2016)... (PRWEB) , ... May 03, 2016 , ... Sue Desmond-Hellmann, ... Class of 2016 to stretch the limits of human possibility in her keynote address ... p.m. in the Georgia Dome. , Drawing on her rich experience as a scientist, ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... , May 3, 2016   BIOTRONIK ... technology, today announced Food and Drug Administration (FDA) ... defibrillator that provides heart failure patients with access ... devices also have remote monitoring with daily automatic ... the heart rate in response to physiological demands. ...
(Date:5/3/2016)... May 3, 2016 Pharmaceutical giant ... million to a woman who says its talc-based powder ... Gloria Ristesund $5 million in compensatory damages ... (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , This ... the company. In February, the same court awarded $72 ...
(Date:5/3/2016)... 2016  Forté Elements, LLC (Forté) is excited to announce the launch of its ... nutritional needs of recovery for a variety of clinical conditions. Founded in 2013, Forté ... http://photos.prnewswire.com/prnh/20160502/362548 Logo -  http://photos.prnewswire.com/prnh/20160502/362547LOGO ... ... ...
Breaking Medicine Technology: