Navigation Links
Enzyme-inhibition could revolutionize molecular imaging
Date:6/9/2014

St. Louis, Mo. (June 9, 2014) The prominent role a single enzyme plays in cancer imaging has eluded researchers for years, but not anymore. This discovery could pave new avenues in nuclear medicine. The enzyme, called neutral endopeptidase (NEP), has a way of breaking down most radiopeptide imaging agents in the body. Researchers have developed an elegant new concept that improves molecular imaging, according to study results presented during the Society of Nuclear Medicine and Molecular Imaging's 2014 Annual Meeting.

The sneaky enzyme has evaded studies with peptide tracers until now because it dwells not in tested blood serum but along the walls of blood vessels and other tissues. In order to combat the degradation of circulating radiopeptides, researchers co-injected a NEP inhibitor called phosphoramidon, derived from bacteria, at the same time as an agent for imaging with single photon emission computed tomography and computed tomography (SPECT/CT). They then applied this method of enzyme inhibition in multiple imaging studies involving a range of radionuclide and peptide counterparts. The results of this research showed consistent successup to 40 times the circulating radiopeptides when protected with phosphoramidon, compared to unprotected controls. This means the simple co-injection of an enzyme inhibitor promotes dramatically improved bioavailability and metabolic stability of radiopeptide imaging agents leading to higher uptake of the agent within targeted tumors and therefore better cancer imaging.

"Oncologists have long sought a powerful 'magic bullet' that can find tumors wherever they hide in the body so that they can be imaged and then destroyed," said Marion de Jong, PhD, a principal researcher for this study conducted at Erasmus Medical Center in Rotterdam, The Netherlands in cooperation with NCSR 'Demokritos' Athens, Greece. "Following this innovative approach, we have been able to induce, for the first time, an impressive i
'/>"/>

Contact: Kimberly Brown
kbrown@snmmi.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A few circulating cancer cells could cue risk of metastases
2. Research could lead to new cancer assay, aid both dogs and humans
3. New definition of kidney disease for clinical trials could lead to new treatments
4. New amyloid-reducing compound could be a preventive measure against Alzheimers
5. Study explains how green tea could reduce pancreatic cancer risk
6. A cure for dry eye could be a blink away
7. Coating stents with vitamin C could reduce clotting risks
8. Could cannabis curb seizures? Experts weed through the evidence
9. Paper-based diagnostics, made with a scrapbooking tool, could curb hepatitis C pandemic
10. Pine bark substance could be potent melanoma drug
11. Biomarker test for Peripartum Cardiomyopathy could help reduce death after giving birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... News) -- Complications are rare among breast cancer ... study indicates. However, the researchers did find ... slightly higher risk for certain complications than a ... 18,000 breast cancer patients who had a single ... reconstruction and were followed for 30 days after ...
(Date:9/2/2014)... 2, 2014 In a large population-based study ... that mild cognitive impairment (MCI) occurred twice more ... 2. Interestingly, this strong association was only observed ... participants (66-80 years) the association vanished. This study ... Disease . , The concept of MCI describes ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 Medex ... location of their corporate headquarters in Coral Springs, Fla. ... have exceeded our business development objectives for the 2014 ... Neil Herbst. “Our industry has requested a higher level ... utilization reviews. Medex has delivered, and the industry has ...
(Date:9/2/2014)... Kathleen Doheny HealthDay ... The U.S. obesity epidemic is a driving force behind the ... study. Researchers looked at data from five national surveys ... increase in diabetes over time could be explained by factors ... U.S. adults. The investigators found that the prevalence of ...
(Date:9/2/2014)... -- Melatonin supplements did not reduce delirium in seniors ... found. Many older hospital patients experience the sudden, ... their normal sleep-wake cycle. A lack of the hormone ... but there has been little research into whether melatonin ... 378 patients, average age 84, who had hip fracture ...
Breaking Medicine News(10 mins):Health News:Complication Rates Low With Mastectomy, Breast Reconstruction: Study 2Health News:Diabetes mellitus and mild cognitive impairment: Higher risk in middle age? 2Health News:Medex Analytic Services Announces New Location for Corporate Headquarters 2Health News:Obesity Fueling Rise in Diabetes Rates, Study Finds 2Health News:Obesity Fueling Rise in Diabetes Rates, Study Finds 3
... Minn. -- A Mayo Clinic study of a drug that ... demonstrates that the drug may also be effective in treating ... The study, which was done in mouse models, is featured ... , The National Cancer Institute reports that of 240,510 ...
... physicians not to disclose bad news to ill loved ... be truthful to the patient with the familys belief ... more successfully manage these conflicts, researchers at the University ... at Stanford University, have developed an approach based on ...
... is overweight when she becomes pregnant, the probability is ... when he/she reaches school age, according to a new ... Alina Rodriguez at Uppsala University in collaboration with international ... of Obesity. , The study, comprising more than 12,500 ...
... Global Med Technologies(R),Inc. (OTC Bulletin Board: GLOB), ... presenting at the Acumen Biofin,Rodman & Renshaw 9th ... the New York Palace Hotel in New York ... Tuesday, November 6th, at 11:15 a.m. EST, Dr. ...
... Technologies,Corporation (Nasdaq: DVAX ) announced today Michael S. ... overview of the,company at two investor conferences in New ... at the CIBC World Markets 18th Annual,Healthcare Conference on ... PT). In addition, Ostrach will present at the Acumen ...
... Arete Therapeutics Inc. today,announced the initiation of ... compound,AR9281, for the treatment of hypertension. AR9281 is ... a novel target,for the treatment of hypertension. The ... and will evaluate the safety, tolerability,pharmacokinetics and pharmacodynamics ...
Cached Medicine News:Health News:Mayo Clinic study shows drug could effectively treat, prevent the spread of breast cancer 2Health News:Mayo Clinic study shows drug could effectively treat, prevent the spread of breast cancer 3Health News:Don't tell mother she has cancer 2Health News:Overweight mothers run greater risk of having hyperactive children 2Health News:Global Med Technologies(R) to Present at Rodman & Renshaw 9th Annual Healthcare Conference 2Health News:Dynavax to Present at CIBC World Markets and Acumen BioFin Rodman and Renshaw Healthcare Conferences 2Health News:Arete Therapeutics Initiates Phase 1 Clinical Trial For AR9281 as a First-in-Class Antihypertensive Agent 2Health News:Arete Therapeutics Initiates Phase 1 Clinical Trial For AR9281 as a First-in-Class Antihypertensive Agent 3
(Date:9/2/2014)... , Sept. 2, 2014 Reportbuyer.com ... Global Markets and Technologies for Molecular Imaging ... STUDY GOALS AND OBJECTIVES The objectives of ... at molecular imaging devices used for diagnostic purposes, ... market and all possible market segments as well ...
(Date:9/2/2014)... 2, 2014 Reportbuyer.com has added a ... Global Markets for Services and Devices ... Bariatric surgery or weight loss surgery is a ... processes that deal with the surgical treatment of ... (endoluminal) and performed in both open and laparoscopic ...
(Date:9/2/2014)... , Sept. 2, 2014 Astellas has appointed ... intellectual property (IP) in the Americas. Kellerman will report ... & general counsel at Astellas. In his new role, ... partner with the business and manage the region,s intellectual ... "I am very pleased to welcome Jim ...
Breaking Medicine Technology:Global Markets and Technologies for Molecular Imaging Devices 2Global Markets and Technologies for Molecular Imaging Devices 3Global Markets and Technologies for Molecular Imaging Devices 4Global Markets and Technologies for Molecular Imaging Devices 5Global Markets and Technologies for Molecular Imaging Devices 6Global Markets and Technologies for Molecular Imaging Devices 7Global Markets and Technologies for Molecular Imaging Devices 8Global Markets and Technologies for Molecular Imaging Devices 9Global Markets and Technologies for Molecular Imaging Devices 10Global Markets and Technologies for Molecular Imaging Devices 11Global Markets and Technologies for Molecular Imaging Devices 12Global Markets and Technologies for Molecular Imaging Devices 13Global Markets and Technologies for Molecular Imaging Devices 14Global Markets and Technologies for Molecular Imaging Devices 15Global Markets and Technologies for Molecular Imaging Devices 16Global Markets and Technologies for Molecular Imaging Devices 17Global Markets and Technologies for Molecular Imaging Devices 18Global Markets and Technologies for Molecular Imaging Devices 19Global Markets and Technologies for Molecular Imaging Devices 20Global Markets and Technologies for Molecular Imaging Devices 21Global Markets and Technologies for Molecular Imaging Devices 22Global Markets and Technologies for Molecular Imaging Devices 23Global Markets and Technologies for Molecular Imaging Devices 24Global Markets and Technologies for Molecular Imaging Devices 25Bariatric Surgery: Global Markets for Services and Devices 2Bariatric Surgery: Global Markets for Services and Devices 3Bariatric Surgery: Global Markets for Services and Devices 4Bariatric Surgery: Global Markets for Services and Devices 5Bariatric Surgery: Global Markets for Services and Devices 6Bariatric Surgery: Global Markets for Services and Devices 7Bariatric Surgery: Global Markets for Services and Devices 8Bariatric Surgery: Global Markets for Services and Devices 9Bariatric Surgery: Global Markets for Services and Devices 10Bariatric Surgery: Global Markets for Services and Devices 11Bariatric Surgery: Global Markets for Services and Devices 12
... NATICK, Mass. and BARCELONA, Spain, May 20 Boston ... results from an analysis of economic and quality of ... SYNTAX trial. The results found that percutaneous coronary ... System was consistently associated with fewer patient hospital days ...
... suggest pirfenidone may provide meaningful clinical benefit in IPF ... safety reported -- Conference Call and Webcast at 9 ... 19 InterMune, Inc. (Nasdaq: ITMN ) ... studies evaluating pirfenidone in patients with idiopathic pulmonary fibrosis ...
Cached Medicine Technology:SYNTAX Analysis Finds Treatment With TAXUS(R) Express2(R) Stent System More Cost Effective Than Bypass Surgery in Patients With Complex Coronary Artery Disease 2SYNTAX Analysis Finds Treatment With TAXUS(R) Express2(R) Stent System More Cost Effective Than Bypass Surgery in Patients With Complex Coronary Artery Disease 3SYNTAX Analysis Finds Treatment With TAXUS(R) Express2(R) Stent System More Cost Effective Than Bypass Surgery in Patients With Complex Coronary Artery Disease 4SYNTAX Analysis Finds Treatment With TAXUS(R) Express2(R) Stent System More Cost Effective Than Bypass Surgery in Patients With Complex Coronary Artery Disease 5Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS) 2Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS) 3Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS) 4Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS) 5Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS) 6Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS) 7Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS) 8Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS) 9Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS) 10Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS) 11Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS) 12
... Spinal Implant system. Material that has a ... bone. The result is an implant that ... support, while optimizing the fusion environment through ... anatomic design with 5 and 10 degrees ...
Cervical distraction screw retractor blade with Casper style distractor...
... Panther Retractor is two system in ... use for all cervicle spine retraction ... aluminium facilitate soft tissue retraction and ... intra-operative imaging with minimal interference. Two ...
Cloward cervical retractor. Size 18 mm....
Medicine Products: