Navigation Links
Enzyme complex could be key to new cancer treatments
Date:4/3/2008

gher rates, suggesting that they play a role in the creation of new purines. In contrast, cells also can produce purines by recycling old purine material. Owing to this salvage process, cells do not always need enzyme clusters; indeed, cluster formation was not observed in cells that were grown in the presence of purines. In a key experiment, the researchers were able to influence the association and dissociation of the enzyme cluster by changing the cells' exposure to purines.

Not all of the cells that were grown in the absence of purines contained enzyme clusters. "We think that the enzymes form clusters only when a cell needs purines, and that happens when a cell is required to replicate its DNA at a certain stage in its cell cycle," said Sheets. "Since each of our samples contain cells at different stages of the cell cycle, we did not expect all of them to be actively replicating their DNA. Therefore, we weren't surprised to find that some of our cells did not contain enzyme clusters."

Because purines are necessary for DNA replication and, ultimately, for cell replication, the ability to halt purine synthesis could prove to be a valuable method for treating cancer. "Cancer cells have very high demands for purines," said Benkovic. "If we can find a way to disrupt the formation of this particular enzyme cluster, it could become a potential new target for cancer therapy."


'/>"/>

Contact: Barbara K. Kennedy
science@psu.edu
814-863-4682
Penn State
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Elevated liver enzymes associated with higher future mortality
2. Enzyme structure reveals new drug targets for cancer and other diseases
3. Genzyme Delivers Strong Fourth Quarter to Conclude Outstanding Year
4. AGI Dermatics Data Indicates 8 Oxo-Guanine Repair Enzyme OGG1 Encapsulated in Liposomes, Reduces MMP-1, Increases Collagen and Enhances DNA Repair
5. First look at an enzyme target for antibacterial and cancer drugs
6. Caught in the act: The dynamic dance of enzymes
7. McGill researchers link enzyme to breast cancer malignancy
8. Telomerase enzyme structure provides significant new target for anti-cancer therapies
9. Genzyme Receives FDA Response Letter on Synvisc-One(TM)
10. Role of a key enzyme in reducing heart disease identified
11. Bioenvision Shareholders Approve Acquisition by Genzyme Corporation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Enzyme complex could be key to new cancer treatments
(Date:12/20/2014)... Today, Balfleet.com, one of the most ... offering 50%-70% off on its Mother of the ... mother of the bride dresses from Balfleet.com feature gorgeous ... accessible and takes pride in providing high quality dresses ... offering great discounts on our mother of the bride ...
(Date:12/19/2014)... Tampa, FL (PRWEB) December 19, 2014 ... Celliant Revitalizing Bedsheets are now available. Celliant, the ... in both sheets and pillowcases. , There are ... clinically proven additional circulation, increased oxygenation and balanced ... quality, faster healing and pain relief; enhanced athletic ...
(Date:12/19/2014)... NY (PRWEB) December 20, 2014 These ... Russia, and other nations. Around 151,000 tons of vanadium ... year. The global vanadium usage increased at 6.7% AAGR ... the steel and iron industry, being the largest consumer, ... in 2013, followed by titanium-vanadium alloy and the chemical ...
(Date:12/19/2014)... (HealthDay News) -- The intestinal bacteria that cause inflammatory ... may be inherited, researchers report. The findings, published ... help in efforts to prevent the disease and treat ... study authors added. "The intestinal bacteria, or ,gut ... have a big impact on your health for the ...
(Date:12/19/2014)... FRIDAY, Dec. 19, 2014 (HealthDay News) -- The cost ... patients, well-being, a new study finds. Researchers examined ... had been diagnosed with colorectal or lung cancer. Of ... were cancer-free, and more than 100 had advanced cancer. ... struggling to pay their medical bills, which was linked ...
Breaking Medicine News(10 mins):Health News:Balfleet.com is Offering 50%-70% Off of its Mother of the Bride Dresses 2Health News:Energy Textiles Launches Celliant Revitalizing Bedsheets 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 3Health News:Crohn's, Colitis May Have Genetic Underpinnings, Study Finds 2Health News:Cancer Treatment Costs Weigh Heavily on Patients, Study Finds 2
... 2009, the congress of the European Association of Cardiovascular ... of a five-year period of heart-healthy political activity in ... of the European Heart Health Charter to the European ... congress joint organiser Professor Joep Perk. "Now is the ...
... WASHINGTON, March 11 On Friday, March 6, ... Department of Justice, the FBI, the FDA, and the Commonwealth ... test. Coast Independent Review Board discovered that a protocol submitted ... Med Systems of Clifton, Virginia, was fraudulent in violation of ...
... Brings 20+ Years of Experience in Complex Rehab IndustryWILKES-BARRE, ... specialist with more than 21 years of experience, has ... of the nation,s fastest growing accredited complex rehab companies. ... and a Certified Rehabilitation Technology Supplier (CRTS) in Wilkes-Barre, ...
... (OTC Bulletin Board: EFSF) announced today that its monthly investor conference ... PM Eastern Time. To participate in the call, please dial 1-877-407-4018 ... at: http://viav i d.net/dce.aspx? ... 0 5 FD1 The conference call will be ...
... -- Orthopaedic surgeon David Teuscher, MD, was elected ... the American Academy of Orthopaedic Surgeons (AAOS) at ... in Las Vegas. He will also serve on the ... one of the voices for our Board of Councilors and ...
... Therapies for Treating Patients With Mutated KRAS Genes ... a New Report from Decision ResourcesWALTHAM, Mass., March ... leading research and advisory firms for pharmaceutical and ... Avastin and Bristol-Myers Squibb/ImClone Systems*/Merck KGaA,s Erbitux will ...
Cached Medicine News:Health News:EuroPRevent 09: Changing hearts and minds in the drive to prevent cardiovascular disease 2Health News:EuroPRevent 09: Changing hearts and minds in the drive to prevent cardiovascular disease 3Health News:Clinical Trial Fraud Exposed by Coast IRB 2Health News:Veteran Rehab Specialist, James Conwell, Joins Fast-Growing Alliance Seating & Mobility in Pennsylvania 2Health News:eFoodSafety.com Announces Investor Conference Call 2Health News:David Teuscher, MD, Elected Secretary of Academy Board of Councilors 2Health News:Use of Avastin and Erbitux in the Adjuvant Setting and Launches of Emerging Agents Will Drive the Colorectal Cancer Drug Market to $7.8 Billion in 2017 2Health News:Use of Avastin and Erbitux in the Adjuvant Setting and Launches of Emerging Agents Will Drive the Colorectal Cancer Drug Market to $7.8 Billion in 2017 3
(Date:12/19/2014)... SAN DIEGO , Dec. 18, 2014  RESMED INC. ... report its second quarter of fiscal year 2015 results on ... market close. A press release with ResMed,s results will be ... will host a webcast to discuss operating results and future ... at 1:30 p.m. US Pacific Time and the live webcast ...
(Date:12/19/2014)... , Dec. 19, 2014  Eli Lilly and ... Paris: FR0011184241 – ADOC) today announced a worldwide licensing ... BioChaperone Lispro, for treatment in people with type 1 ... proprietary BioChaperone® technology and is currently in Phase Ib ... Lispro with the goal of optimizing glucose levels during ...
(Date:12/17/2014)... Revenue and earnings above the previous year - ... In the past 2013/14 fiscal year (ended 30 September ... 4.287 billion (last year: EUR 4.190 billion) despite unfavorable currency ... million. "Overall, 2013/14 was a successful fiscal year for the ... CEO of Carl Zeiss AG. "Thanks to our broad portfolio ...
Breaking Medicine Technology:ResMed To Announce Second Quarter 2015 Results 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 3ZEISS Asserts its Position in Difficult Environment 2
... Holdings, Inc. ("Bacterin") (OTC Bulletin Board: BIHI ... announced that it launched its OsteoSponge®SC product at the ... taking place February 15-19 in San Diego, CA.  Based ... the Food and Drug Administration to market OsteoSponge®SC as ...
... Feb. 16, 2011 MedAptus®, the market leader ... England Baptist Hospital (NEBH) has selected the company,s ... medicine providers. The NEBH hospitalist team, comprised of ... Inpatient Edition via the web as well as ...
Cached Medicine Technology:Bacterin International to Announce Launch of OsteoSponge®SC at American Academy of Orthopedic Surgeons 2011 Annual Meeting February 15-19 2Bacterin International to Announce Launch of OsteoSponge®SC at American Academy of Orthopedic Surgeons 2011 Annual Meeting February 15-19 3Hospitalists at New England Baptist Hospital Choose MedAptus 2
Straight shafts with teeth and 5 mm tying platform. Wide serrated handle with polished finish. Teeth: 0.3 mm. Manufactured in titanium....
Ergotec Vetriretinal Instrument System. Extra fine angled tips (3 mm). 20 ga. shaft tapering to 23 ga., 10 mm from tip. Overall length from rear rotation knob to tip....
Ergotec Vetriretinal Instrument System. 2 mm pointed black tips with 0.6 mm platform. 20 gauge shaft tapers to 23 gauge....
Ergotec Vetriretinal Instrument System. Ultra-fine 0.8 mm tips. Angled 40 degrees. 20 gauge shaft tapers to 23 gauge....
Medicine Products: