Navigation Links
Enzyme action could be target for diabetes, heart disease treatments
Date:11/16/2010

us members of the HDAC family of proteins and found that only HDAC9 showed a direct correlation to differentiation of precursor fat cells, both from human and mouse fat tissues.

"HDAC9 down-regulation is necessary for the differentiation of precursor fat cells to mature fat cells; forced up-regulation of HDAC9 by genetic manipulation blocks the differentiation of the precursor fat cells," Chatterjee says. "On the other hand, precursor fat cells from HDAC9 genetic knockout mice showed accelerated differentiation.

"We believe that HDAC9 keeps precursor fat cells in the undifferentiated state; metabolic cues trigger HDAC9 down-regulation allowing conversion of the precursor cells to mature fat cells. We are exploring the cellular signaling mechanism that promotes such down-regulation of this enzyme during the normal fat cell differentiation process."

Chatterjee says researchers were really interested in the tie between increased HDAC9 levels in fat tissue of mice and the caloric overload.

"Fat tissues from these obese mice showed dysfunction, with increased expression of pro-inflammatory agents and decreased expression of hormones responsible for maintaining whole body lipid and glucose stability," he says. "The fat tissues of these mice are not capable of efficiently storing excess calories and are not able to perform proper endocrine functions.

"The adaptive response fails for some reason during chronic caloric overload, leading to the generation of fat tissue mass that is dysfunctional."

Chatterjee says the HDAC9 level in fat cells is the underlying molecular culprit for dysfunctional fat tissue during obesity.

"We are currently examining HDAC9 knockout mice subjected to chronic high-fat feeding and think that HDAC9 gene removal will protect mice from obesity-linked adipose tissue dysfunction and associated metabolic disorders," he says.

"Identification of HDAC9 as a novel regulator of f
'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New 3-D model of RNA core domain of enzyme telomerase may offer clues to cancer, aging
2. Intestinal enzyme helps maintain population of beneficial bacteria
3. Diabetes gene linked to degeneration of enzyme involved in Alzheimers disease onset and progression
4. Researchers identify key enzyme in DNA repair pathway
5. Researchers identify key enzyme in melanoma cell development
6. New evidence that smokeless tobacco damages DNA and key enzymes
7. New technique permits development of enzyme tool kit
8. Watch Your Cholesterol, Your Blood Pressure ... and This Enzyme?
9. California Day Spa - Osmosis Celebrates 25th Anniversary With Over 200,000 Cedar Enzyme Baths Given
10. New Osteoarthritis Research Grant Program Initiated by AOSSM and Genzyme Biosurgery
11. Scientists find donut-shaped structure of enzyme involved in energy metabolism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... 26, 2014 2014 Deep ... Permeation Chromatography Industry” is a professional and ... China Gel Permeation Chromatography market. The report ... Gel Permeation Chromatography definition, classification, application, and ... overview. This research covers the international market ...
(Date:7/25/2014)... July 25, 2014 A federal judge ... in two DePuy Pinnacle hip lawsuits ( http://www.depuypinnacle-lawsuit.com/ ... the claims to go before a jury on September ... rendered on July 18th, U.S. District Judge Ed Kinkeade ... two Plaintiffs’ claims may proceed to trial against Johnson ...
(Date:7/25/2014)... Seniors are more easily distracted during thinking and memory ... "Almost any type of memory test administered reveals a ... study co-author Randi Martin, professor of psychology at Rice ... Martin said, this study shows that "environmental interference" has ... with younger adults. The study included 60 seniors, ...
(Date:7/25/2014)... As reported by People Magazine in the ... Shore and Getting Sober (7/15), one of the most ... spoken out to the public about his personal transformation. Now, ... Situation admits that moving on with his life was a ... other drugs in 2012 and even spent some time in ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 AttorneyOne.com, a recognized ... latest information from the FDA on Ibuprofen and Oxcarbazepine ... that one lot of Ibuprofen and one lot of Oxcarbazepine ... due to mislabeled packaging. Oxcarbazepine is used for the treatment ... , The reason for the recall is that Lot ...
Breaking Medicine News(10 mins):Health News:2014 China & Global GPC Industry - Gel Permeation Chromatography Development Trends Now at DeepResearchReports.com 2Health News:2014 China & Global GPC Industry - Gel Permeation Chromatography Development Trends Now at DeepResearchReports.com 3Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 2Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 3Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 4Health News:Distractions Seem More Troublesome With Age 2Health News:'The Situation' Celebrates 8 Months of Sobriety 2Health News:'The Situation' Celebrates 8 Months of Sobriety 3Health News:Ibuprofen and Oxcarbazepine Tablets Recalled: AttorneyOne Monitors and Keep Consumers Informed 2
... is hosting a,day-long program for survivors, families, caregivers and ... and improving quality of life. The program, sponsored ... place from 10 a.m. - 4:30 p.m., Friday, Nov. ... years, Henry Ford Hospital has been designated a Stroke,Center ...
... Jerusalem, Nov. 8, 2007 An Israeli-Jordanian-U.S. cooperative project ... the neighboring southern cities of Aqaba in Jordan and ... the Hebrew University of Jerusalem together with scientists from ... Desert Research Institute of Reno, Nevada, in the US. ...
... say , THURSDAY, Nov. 8 (HealthDay News) -- The areas ... a person can be absolutely certain of a past event ... say Duke University Medical Center researchers. , They used functional ... volunteers as they performed tests of both memory and false ...
... Best Recipe for Healthy Skin, NEW YORK, Nov. 8 ... applies to our overall health and nutrition, but how our ... the body, our skin can,benefit from the same nutrition we ... and other major organs. In fact, new research suggests,that eating ...
... of Stress on the Skin, Hair and ... ... final exams. A messy divorce. An unexpected surgery. What do,they all have in ... toll on a person physically and psychologically, it also,can lead to dermatologic problems, ...
... Students with Free Dental Screenings, ... Oral Health Education, MIAMI, Nov. 8 A national ... when more than 250 Coconut Grove,Elementary School students joined Colgate-Palmolive ... Miami for a lively game-show themed dental,challenge that featured music, ...
Cached Medicine News:Health News:'Beam of Light' is ray of hope for Israeli-Jordanian cooperation 2Health News:Brain Yields Clues to False Memories 2Health News:Taking Care of Your Skin Starts From Within 2Health News:Taking Care of Your Skin Starts From Within 3Health News:Taking Care of Your Skin Starts From Within 4Health News:Taking Care of Your Skin Starts From Within 5Health News:Feeling Stressed? 2Health News:Feeling Stressed? 3Health News:Feeling Stressed? 4Health News:"High School Musical's" Corbin Bleu Joins Colgate-Palmolive, United Way and Miami-Dade Elementary School Students for Dental Health Challenge 2Health News:"High School Musical's" Corbin Bleu Joins Colgate-Palmolive, United Way and Miami-Dade Elementary School Students for Dental Health Challenge 3
(Date:7/25/2014)... According to a new market ... Insulin Market (Rapid-Acting, Short-Acting, Intermediate-Acting, Long-Acting, Premixed, Modern and ... and Forecast (Value and Volume), 2013 - 2019", the ... in 2012 and is expected to grow at a ... USD 32.24 billion in 2019. Browse the ...
(Date:7/25/2014)... 25, 2014  IDEXX Laboratories, Inc. (NASDAQ: ... quarter of 2014 increased 11% versus the prior year ... for the second quarter of 2014 versus the prior ... in distributor inventory 2 . Earnings per diluted share ... 11% from the prior year period to $1.10."In the ...
(Date:7/25/2014)... 2014 Leading events organizer UBM Live ... the seventh year to São Paulo, Brazil ... 2014. The event will co-locate with Food Ingredients South America ... meeting point for the pharmaceutical industry.      (Logo: ... pharmaceutical sales are now exploring the South America ...
Breaking Medicine Technology:Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 2Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 3Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 4IDEXX Laboratories Announces Second Quarter Results 2IDEXX Laboratories Announces Second Quarter Results 3IDEXX Laboratories Announces Second Quarter Results 4IDEXX Laboratories Announces Second Quarter Results 5IDEXX Laboratories Announces Second Quarter Results 6IDEXX Laboratories Announces Second Quarter Results 7IDEXX Laboratories Announces Second Quarter Results 8IDEXX Laboratories Announces Second Quarter Results 9IDEXX Laboratories Announces Second Quarter Results 10IDEXX Laboratories Announces Second Quarter Results 11IDEXX Laboratories Announces Second Quarter Results 12IDEXX Laboratories Announces Second Quarter Results 13IDEXX Laboratories Announces Second Quarter Results 14IDEXX Laboratories Announces Second Quarter Results 15IDEXX Laboratories Announces Second Quarter Results 16IDEXX Laboratories Announces Second Quarter Results 17IDEXX Laboratories Announces Second Quarter Results 18IDEXX Laboratories Announces Second Quarter Results 19IDEXX Laboratories Announces Second Quarter Results 20IDEXX Laboratories Announces Second Quarter Results 21IDEXX Laboratories Announces Second Quarter Results 22IDEXX Laboratories Announces Second Quarter Results 23IDEXX Laboratories Announces Second Quarter Results 24IDEXX Laboratories Announces Second Quarter Results 25IDEXX Laboratories Announces Second Quarter Results 26IDEXX Laboratories Announces Second Quarter Results 27IDEXX Laboratories Announces Second Quarter Results 28IDEXX Laboratories Announces Second Quarter Results 29IDEXX Laboratories Announces Second Quarter Results 30IDEXX Laboratories Announces Second Quarter Results 31IDEXX Laboratories Announces Second Quarter Results 32IDEXX Laboratories Announces Second Quarter Results 33
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: